A Clinical and Pharmacokinetic Comparison of Ropivacaine and Bupivacaine in Axillary Plexus Block

Vainionpää, Vilho; Haavisto, E.; Huha, Teija M.; Korpi, Kauko J.; Nuutinen, L; Hollmén, A; Jozwiak, H.; Magnusson, Asa A.

doi:10.1213/00000539-199509000-00019

Cited by 25 publications

(35 citation statements)

References 13 publications

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“…Different studies found that 0.5% ropivacaine was as equipotent as 0.5% bupivacaine in providing adequate brachial plexus block. [9][10][11] Klein N S et al and Bertini et al, in their studies of increasing concentration of ropivacaine from 0.5% to 0.75% failed to improve onset and duration of the interscalene brachial plexus block. 8,12 However Casati et al reported that ropivacaine was suitable and safe local anesthetic for brachial plexus block at a dose of 2.5-2.6 mg/kg without any adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of 0.5% ropivacaine and 0.5% bupivacaine for brachial plexus block by supraclavicular approach for upper limb surgeries

Modak

Basantwani

2016

Int J Basic Clin Pharmacol

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Section: Discussionmentioning

confidence: 99%

Comparative study of 0.5% ropivacaine and 0.5% bupivacaine for brachial plexus block by supraclavicular approach for upper limb surgeries

Modak

Basantwani

2016

Int J Basic Clin Pharmacol

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“…Ropivacaine in comparison to other aminoamides like bupivacaine is less cardiotoxic and less neurotoxic. 3 As compared with bupivacaine, ropivacaine produces less intense motor block, and of shorter duration, permitting earlier mobilization and discharge. Local anesthetics have a limited duration of action.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Magnesium Sulfate as Adjuvant to Ropivacaine 0.4% for Supraclavicular Brachial Plexus Block in Patients undergoing Upper Limb Surgery: A Randomized Controlled Trial

Gupta

Mangal

Sharma

et al. 2017

Journal on Recent Advances in Pain

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Objectives: To prolong the duration of brachial plexus block, different adjuvants have been used. We evaluated the effect of adding magnesium sulfate to local anesthetic ropivacaine 0.4% for institution of supraclavicular brachia plexus block. Onset of sensory and motor block, duration of motor block, and rescue analgesia were observed. Materials and methods:Total 120 patients (20-50 years) scheduled for elective surgeries of upper limb under supraclavicular brachial plexus block were randomized into two groups. Group I received 24 mL 0.5% ropivacaine (120 mg) + 6.0 mL normal saline (NS) to make total volume of 30 mL. Group II received 24 mL 0.5% ropivacaine (120 mg) + 150 mg magnesium sulfate + 5.5 mL NS to make total volume of 30 mL. Results:Onset of sensory block in group I was 16.63 ± 2.79 min and in group II was 17.33 ± 2.25 min (statistically not significant, p > 0.05). Onset of motor block in group I was 18.63 ± 2.79 min and in group II was 19.76 ± 2.18 min (statistically significant, p < 0.05). The duration of motor block was significantly longer in group II; 322.00 ± 81.35 min than group I; 260.25 ± 66.79 min (p < 0.05). Similarly, time of rescue analgesia was significantly prolonged in group II; 491 ± 100.22 min than group I; 377.67 ± 73.31 min (p < 0.05). Conclusion:From our study, we concluded that the addition of 150 mg magnesium sulfate as adjuvant to 30 mL of 0.4% ropivacaine in comparison to 30 mL of 0.4% ropivacaine provides longer duration of analgesia. Although the onset of sensory block is not affected, onset of motor block is delayed. Motor block lasts for longer duration.

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“…The BPB anesthetize the blocked member for a long time about 8.3 h similar to another study which used multiple injections in dogs with 0.375% bupivacaine with vasoconstrictor (4mg/kg) got an 11 h analgesic period 12 . In this sense, a study aiming a long duration anesthesia comparing 0.5% ropivacaine and 0.5% bupivacaine in plexus brachial block in humans do not found significant difference in relation the beginning and duration of the anesthesia between the two treatments (7.1 and 11.5 h, respectively) 16 . Probably, the period of analgesia of this experiment was lower due to the low concentration (0.25%) and the solution used was without vasoconstrictor.…”

Section: Discussionmentioning

confidence: 82%

Evaluation of two regional anesthetic methods on the front limb of dogs using hyperbaric bupivacaine

2010

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PURPOSE: To evaluate the effects of bupivacaine 0.5 and 0.25% in intravenous regional anesthesia (IVRA) and brachial plexus block (BPB), respectively, on anesthesia, motor block and cardiovascular parameters in dogs. METHODS: Fourteen healthy adult dogs averaging 10 kilograms (kg) of body weight. Animals were randomly assigned to receive one of the two treatments IVRA (n=7) or BPB (n=7). All the animals were sedated with acepromazine (0.1 mg/kg intramuscular). To execute the BPB was used an electrical nerve stimulation. Anesthesia, motor block, sedation, cardiovascular and respiratory effects were measured as effect of the treatment. RESULTS: BPA showed superior efficiency and duration of anesthesia (BPB - 456 ± 94 minutes vs IVRA - 138 ± 44) as well as motor block. There only physiologic parameter which change were the systolic pressure in BPB and respiratory rate for both treatments. CONCLUSION: In dogs the 0.25 % hyperbaric bupivacaine in BPB produces a front limb anesthesia about three times more than the 0.5 % in IVRA, with ptosis of the limb blocked and little interference in the cardiovascular system but with decrease in respiratory rate.

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A Clinical and Pharmacokinetic Comparison of Ropivacaine and Bupivacaine in Axillary Plexus Block

Cited by 25 publications

References 13 publications

Comparative study of 0.5% ropivacaine and 0.5% bupivacaine for brachial plexus block by supraclavicular approach for upper limb surgeries

Comparative study of 0.5% ropivacaine and 0.5% bupivacaine for brachial plexus block by supraclavicular approach for upper limb surgeries

Efficacy of Magnesium Sulfate as Adjuvant to Ropivacaine 0.4% for Supraclavicular Brachial Plexus Block in Patients undergoing Upper Limb Surgery: A Randomized Controlled Trial

Evaluation of two regional anesthetic methods on the front limb of dogs using hyperbaric bupivacaine

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