A clinical and pathological staging system for soft tissue sarcomas

Russell, William O.; Cohen, Jonathan B.; Enzinger, Franz M.; Hajdu, Steven I.; Heise, Herman W.; Martin, Randi C.; Meissner, William A.; Miller, Wallace T.; Schmitz, R.; Suit, Herman D.

doi:10.1002/1097-0142(197710)40:4<1562::aid-cncr2820400428>3.0.co;2-6

Cited by 701 publications

(231 citation statements)

References 13 publications

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“…Grade is depending on the number of mitoses, the degree of cellular and nuclear atypia, and the presence and extent of necrosis [2,3,15]. According to the American Joint Committee staging system for soft-tissue sarcomas [2,3,16], the grade of the tumor directly determines the stage of the disease. Tumor size is the second determinant of the stage.…”

Section: Discussionmentioning

confidence: 99%

Challenges in the Surgical Treatment of Retroperitoneal Sarcomas

et al. 2015

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The objective of this study is to assess long-term prognosis and patterns of failure in patients with retroperitoneal sarcoma who underwent surgery with curative intent at a single institution. We also provide a thorough review of the literature including several series and widely variable data regarding local and distant failure. During a 25-year period , 45 consecutive patients who underwent surgery for retroperitoneal sarcoma at a single referral center were reviewed retrospectively. We recorded and analyzed the presenting symptoms, type of surgical excision, and the 5-year survival rate as well as the local recurrence rate of patients with complete tumor resection. Overall survival is significantly diminished in patients in whom resection margins are not adequate. In our series, 5-year recurrence rate for patients with complete and incomplete resection of the tumor was 30.76 and 68.42 %, respectively. The 5-year survival rate was 51.12 %, and the 5-year survival rate according to type of resection was 76.93 % for complete and 15.79 % for incomplete resections. Local recurrence after first surgery and high-grade malignancy are associated with poor survival. The role of radiation therapy and chemotherapy in the treatment of retroperitoneal sarcoma (RPS) should be investigated further. Complete en bloc resection of the tumor mass and adjacent structures is the single most important factor that improves survival.

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Section: Discussionmentioning

confidence: 99%

Challenges in the Surgical Treatment of Retroperitoneal Sarcomas

et al. 2015

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“…All patients had not had preoperative chemotherapy or radiotherapy at the time of initial surgery. All tumors were staged according to the American Joint Committee on Cancer (AJCC) staging of soft tissue sarcomas (21).…”

Section: Methodsmentioning

confidence: 99%

Prognostic Significance of Apoptosis in Synovial Sarcoma: Correlation with Clinicopathologic Parameters, Cell Proliferative Activity, and Expression of Apoptosis-Related Proteins

et al. 2000

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bcl-2 overexpression in synovial sarcomas has been recently reported. Although it is widely known that bcl-2 suppresses apoptosis in various cells, there are no studies that have examined the significance of apoptosis in synovial sarcoma. In the present study, we visualized apoptotic tumor cells by the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate in situ nick end-labeling (TUNEL) method in 49 cases of primary synovial sarcoma. The degree of apoptosis was analyzed in relation to several clinicopathologic parameters, cell proliferative activity, and immunohistochemical expression of apoptosis-related proteins, including bcl-2, bax, bcl-x, bak, p53, p21 (WAF1/CIP1), Fas, and Fas ligand. TUNEL index (TUNEL-I) significantly correlated with the mitotic index (MI) (ñ ‫؍‬ 0.60, P < .0001) and Ki-67 labeling index (MIB1-I) (ñ ‫؍‬ 0.52, P ‫؍‬ 0.0005). There was a highly significant association between high TUNEL-I value (>.8%) and poor prognosis (log-rank test; P < .0001). Many synovial sarcomas were diffusely positive for bcl-2 family proteins (bcl-2, bax, bcl-x, and bak) and were negative or only sporadically positive for Fas, Fas ligand, p53, and p21 (WAF1/CIP1) proteins. The results indicated that increased rate of apoptosis in primary synovial sarcoma was considered to be an indicator of poor prognosis. In addition, apoptosis in synovial sarcoma may be controlled by multiple apoptosis-regulating mechanisms, including the bcl-2 family.

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“…Other terms used to describe this entity are synovial cell sarcoma and malignant synovioma [9,10]. Although the term synovioma implies a benign condition, further investigations have exposed the aggressive nature of this neoplasm and eventually led to its classification as a high-grade tumor by the American Joint Committee on Cancer [11].…”

Section: Discussionmentioning

confidence: 99%