A Clinical and PATHOLOC.ICAL Study of Placenta Accreta

Millar, W. Gordon

doi:10.1097/00006254-196002000-00018

Cited by 2 publications

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“…In addition to decidual deficiency, several studies have suggested excessive trophoblast invasion may contribute to the pathogenesis of API and suggested various abnormalities in both trophoblastic subtypes (the interstitial trophoblast and the endovascular trophoblast) (9).…”

mentioning

confidence: 99%

Abnormal Placental Invasion—a Novel Approach to Treatment

Ophir¹,

Singer-Jordan²,

Odeh³

et al. 2009

Obstetrical &Amp; Gynecological Survey

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The incidence of abnormal placental invasion has increased 10-fold in the past 50 years, reflecting the increased number of cesarean sections performed. Management relies on accurate early diagnosis with appropriate perioperative multidisciplinary planning to anticipate and avoid massive obstetric hemorrhage at delivery. Women at risk should plan to deliver at an institution with appropriate expertise and resources for managing this condition. We report a case of placenta increta management comprising preoperative placement of a pelvic artery balloon catheter, prophylactic balloon occlusion after delivery of the fetus, and embolization-assisted resection of the invaded uterine wall. We review incidence, methods of prenatal diagnosis, risk factors, and management of abnormally invasive placenta.

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mentioning

confidence: 99%

Abnormal Placental Invasion—a Novel Approach to Treatment

Ophir¹,

Singer-Jordan²,

Odeh³

et al. 2009

Obstetrical &Amp; Gynecological Survey

View full text Add to dashboard Cite

show abstract

“…Placentas acretas são histologicamente caracterizadas pela ausência de decídua, com contato direto do tecido viloso com o miométrio subjacente (BENIRSCHKE et al, 2006) e por isso, consideradas entre muitos autores como uma patologia totalmente iatrogênica (JAUNIAUX; JURKOVIC, 2012). A etiologia da doença é atribuída à consequente falta de modulação direta das células deciduais sobre as células trofoblásticas extravilosas (EVTs) (IRVING et al, 1937;MILLER et al, 1959;FOX, 1972;HUTTON et al, 1983). Corroborando essa hipótese, estudos demonstraram que a probabildade de desenvolvimento da placenta acreta aumenta na presença de placentação prévia (CLARK et al, 1985;SILVER et al, 2006), a qual tem sua inserção em pontos uterinos onde a decidualização é menos intensa (KHONG, 2008).…”

Section: Estrutura Placentáriaunclassified

CRIPTO1: expressão e possíveis ações sobre as células citotrofoblásticas extravilosas humanas.

Bandeira¹

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CRIPTO1 is a member of the family of proteins of the epidermal growth factor-CRIPTO1 / FRL1 / Cryptic (EGF-CFC) that performs specific functions during embryonic development and tumor. In the first case, it acts as required co-receptor for Nodal in the correct establishment of embryonic axys. In the second case, it was found that it is secreted at high levels by a variety of human cancers (colon, breast, lung, testis, ovary, pancreas and stomach etc.), but is absent or is weakly expressed in normal tissues. Therefore, this study was to ascertain the presence of CR1 in healthy placenta and those with invasiveness disorders, since the development of trophoblast in maternal fetal interface resembles in many ways the oncogenic process. Our results showed a pattern of distinct expression between first and third trimester of pregnancy, with the presence of CR3 and CR1, respectively. Choriocarcinoma were also immunoreactive for the protein, which still showed a positive relationship with the placenta acreta. Our in vitro studies have shown that recombinant CR1 has inducing action in HTR8/SV-Neo cells, significantly increasing the invasion and migration, the latter process is significantly abolished in the presence of RNA interference. In conclusion, CRIPTO1 is expressed mainly in extravillous cytotrophoblast cells in normal pregnancy in the first and third trimester of pregnancy. In the first trimester the distribution of this expression in the process of differentiation in cells in invasive cells suggests a role in this process. In placenta acreta with the increased of the trophoblastic invasiveness besides the endometrial limits, there is an increased expression of this factor, which is also found in malignant choriocarcinoma cytotrophoblast cells. The immunolocalization of CRIPTO1 in these samples strongly suggests the involvement of this factor in functional activities of trophoblast cells, such as invasiveness and differentiation. The increase in migration of these cells after treatment with CRIPTO1 and the attenuation of this process in cells with CRIPTO gene silenced confirm experimentally the action of this protein in the trophoblastic cells. This study contributes to the identification of factors associated with trophoblast invasiveness in normal and pathological conditions.

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A Clinical and PATHOLOC.ICAL Study of Placenta Accreta

Cited by 2 publications

References 0 publications

Abnormal Placental Invasion—a Novel Approach to Treatment

Abnormal Placental Invasion—a Novel Approach to Treatment

CRIPTO1: expressão e possíveis ações sobre as células citotrofoblásticas extravilosas humanas.

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