A Clinical and Histopathological Study of 122 Cases of Dermatofibroma (Benign Fibrous Histiocytoma)

Abstract

Background: Many variants of dermatofibromas have been described, and being aware of the variants of dermatofibromas is important to avoid misdiagnosis. Objective: We wanted to evaluate the clinical and pathologic characteristics of 122 cases of dermatofibromas. Methods: We retrospectively reviewed the medical records and 122 biopsy specimens of 92 patients who were diagnosed with dermatofibroma in the Department of Dermatology at Eulji Hospital of Eulji University between January 2000 and March 2010. Results: Nearly 80% of the cases occurred between the ages of 20 and 49 years, with an overall predominance of females. Over 70% of the lesions were found on the extremities. The most common histologic variant was a fibrocollagenous dermatofibroma (40.1%). Other variants included histiocytic (13.1%), cellular (11.5%), aneurysmal (7.4%), angiomatous (6.5%), sclerotic (6.5%), monster (4.9%), palisading (1.6%) and keloidal dermatofibromas (0.8%). There were 9 dermatofibromas (7.3%) that were the mixed type with two co-dominant histologic features. Conclusion: The results of this study are consistent with previous reports on the clinical features of dermatofibromas. However, we observed several characteristic subtypes of dermatofibroma and we compared the frequency of the histologic subtypes.

LAMTOR1-PRKCD and NUMA1-SFMBT1 fusion genes identified by RNA sequencing in aneurysmal benign fibrous histiocytoma with t(3;11)(p21;q13)

“…It represents less than 8% of all BFHs [3,4,23] and, in contrast to common fibrous histiocytomas which recur only exceptionally (in <2%), recurrences following incomplete excision of aneurysmal BFH have been reported in up to 19% of the cases [23,24].…”

“…A variable admixture of inflammatory cells, coarse collagen bundles in haphazard array, and variable epidermal, melanocytic and folliculosebaceous hyperplasia is present" [2]. BFHs may develop at any age but most of them are diagnosed during the second to fourth decades [3,4]. There is an overall female preponderance with reported ratios of 2.6:1 and 2.2:1 [3,4].…”

“…The most common location of BFH is the legs, followed by the arms, buttocks, chest, face, abdomen, back, hand, and feet in order of decreasing frequency [3,4]. Rare cases of BFH have been reported in the tongue and maxilla [5,6].…”

“…Rare cases of BFH have been reported in the tongue and maxilla [5,6]. Several histologic variants have been described such as fibrocollagenous, cellular, histiocytic, lipidized, angiomatous, aneurysmal, clear cell, monster cell, myxoid, keloidal, palisading, osteoclastic, and epithelioid dermatofibroma [3,4]. BFHs arising subcutaneously or in deep soft tissues as well as in bone (non-ossifying fibroma) have also been described [7][8][9].…”

Pattern Analysis Of Purely Dermal Cutaneous Mesenchymal Tumours Presenting As Superficial Palpable Growth

“…[2,15] Benign Fibrous Histiocytic Tumours (8.5%): Dermatofibroma (benign fibrous histiocytoma) ( Figure-6) is a common skin lesion and it accounts for approximately 3% of the all skin lesions. [17] In the present study it was the least common tumor and accounted for 6.7% of cases. Most common clinical presentation was of slow, nodular, well circumscribed growth in the upper extremity with no sex predilection.…”