A clinical analysis of systemic chemotherapy combined with radiotherapy for advanced gastric cancer

Dong, Hongmin; Wang, Qin; Wang, Wenling; Wang, Gang; Li, Xiaokai; Li, Guodong; Chen, Juan

doi:10.1097/md.0000000000010786

Cited by 7 publications

(8 citation statements)

References 19 publications

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“…Despite advances in surgical techniques and combined chemotherapy strategies, the 5-year overall survival (OS) of GC remains poor [3]. The lack of improvement in OS is largely due to a low early diagnostic rate and a high frequency of recurrence and metastasis [4, 5]. Therefore, elucidation of the molecular mechanisms underlying GC is imperative for the development of effective diagnostic and therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

Identification of circRNA–miRNA–mRNA regulatory network in gastric cancer by analysis of microarray data

Guan

Song

2019

Cancer Cell Int

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Background: Evidence is increasingly indicating that circular RNAs (circRNAs) are closely involved in tumorigenesis and cancer progression. However, the function of circRNAs in gastric cancer (GC) are still unknown. Here, we aimed to determine the regulatory mechanism of circRNAs in GC. Methods: Expression profiles of circRNAs were downloaded from four Gene Expression Omnibus (GEO) microarray datasets. Expression profiles of miRNAs and mRNAs were collected from The Cancer Genome Atlas (TCGA) database. We used the robust rank aggregation method to identify differentially expressed circRNAs (DEcircRNAs) and a ceRNA network was constructed based on circRNA-miRNA pairs and miRNA-mRNA pairs. Functional and pathway enrichment analyses were performed and interactions between proteins were predicted using Cytoscape. Aa subnetwork regulatory module was built using the MCODE plugin. Results: A total of eight DEcircRNAs, 240 DEmiRNAs, and 4578 DEmRNAs were identified. The circRNA-miRNA-mRNA network was constructed based on seven circRNAs, 33 miRNAs, 69 mRNAs in GC. GO and KEGG pathway analysis indicated DEmRNAs might be associated with GC onset and progression. A PPI network was established and four hub genes (MCM4, KIF23, MCM8, and NCAPD2) were determined from the network. Then a circRNA-miRNA-hub gene subnetwork was constructed based on the four DEcircRNAs, three DEmiRNAs, and four DEmRNAs. Conclusions: Our findings provide a deeper understanding the circRNA-related competing endogenous RNA regulatory mechanism in GC pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Identification of circRNA–miRNA–mRNA regulatory network in gastric cancer by analysis of microarray data

Guan

Song

2019

Cancer Cell Int

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“…According to the search strategy of this study, a total of 954 related studies were obtained in the initial examination, and 30 RCTs were included in quantitative synthesis ultimately [ 13 – 42 ]. The PRISMA flow diagram of studying selection is shown in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Effectiveness and Safety of Oral Chinese Patent Medicines Combined with Chemotherapy for Gastric Cancer: A Bayesian Network Meta-Analysis

Zheng

Fang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objectives. This network meta-analysis (NMA) was designed to assess the comparative effectiveness and safety of oral Chinese patent medicines combined with chemotherapy for gastric cancer on the National Basic Medical Insurance Drugs List of China. Methods. A comprehensive literature search was performed in seven electronic databases from their inception to February 25, 2020, aiming to collect all related randomized controlled trials (RCTs) to evaluate the effectiveness and safety of oral Chinese patent medicines as an adjuvant for gastric cancer. Two researchers independently screened the literature, extracted data, and assessed the risk of bias of included studies using the Cochrane Risk of Bias Scale. NMA was then performed by using STATA 16.0 software and ADDIS 1.16.8 software. Results. Finally, 30 RCTs were included, involving seven kinds of oral Chinese patent medicines, with a total of 2602 patients. For improvement of clinical efficacy, Bazhen granule combined with chemotherapy was ranked first for effectiveness, followed by the Cinobufacin capsule combined with chemotherapy and Xiao’aiping tablet combined with chemotherapy. Meanwhile, Bazhen granules combined with chemotherapy also were ranked first in reducing gastrointestinal reactions. In terms of improving performance status, the Xiao’aiping tablet was the best and significantly better than other oral Chinese patent medicines. Besides, the Zhenqi Fuzheng granule combined with chemotherapy was best for reducing the incidence of leucopenia. Conclusions. Since only one RCT of Bazhen granule was included in this study for analysis, its statistical efficiency is low. Therefore, this study recommends that the Cinobufacin capsule combined with chemotherapy should be a priority in improving clinical efficacy. In terms of improving patients’ quality of life, Xiao’aiping tablet is the best choice. Safety was best for Zhenqi Fuzheng granule and Bazhen granule combined with chemotherapy. Limited by the quantity, quality, and possible bias of included studies, the above conclusions need to be further verified by more high-quality RCTs.

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“…В 2018 г. H.M. Dong et al опубликовали результаты исследования, в котором были проанализированы данные 194 больных местнораспространенным РЖ, разделенных на 2 группы: пациенты, получившие адъювантную химиотерапию (n=92) и химиолучевую терапию (n=102). При ХЛТ отмечено значимое снижение частоты рецидивов, а также более высокий уровень показателей 2-летней выживаемости (13,7 %) по сравнению с группой получавших химиотерапию -7,6 % (р <0,05) [26].…”

Section: значение адъювантной химиотерапии в лечении местнораспростраunclassified

The Role of Adjuvant Chemotherapy in the Treatment of Locally Advanced Gastric Cancer

et al. 2021

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The purpose of the study was a systemic literature review on data regarding the efficacy, safety and prospects for the use of adjuvant chemotherapy for locally advanced gastric cancer.Material and Methods. The study contained a thorough literary analysis of the results of international studies on the use of preoperative and postoperative chemotherapy for locally advanced gastric cancer. Relevant sources were searched in Medlin and Cochrane Library databases, and publications from 2001 to 2019 were included. Of all the studies analyzed, 28 were used to write the systematic review.Results. The increase in survival rates was mainly achieved due to the use of a multimodal approach to the treatment of gastric cancer. The effectiveness of this approach, which combined surgery with chemotherapy or chemoradiotherapy, was proven in several large clinical studies. However, despite the large number of treatment options for locally advanced gastric cancer, there is still no single standard for the management of patients with this disease. One of the treatment options successfully practiced in a number of leading countries is the use of adjuvant chemo/chemoradiation therapy.Conclusion. Analysis of the literature data of the last 18 years has shown the high relevance of studies on adjuvant chemotherapy for gastric cancer and the need to continue further study of this problem.

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A clinical analysis of systemic chemotherapy combined with radiotherapy for advanced gastric cancer

Cited by 7 publications

References 19 publications

Identification of circRNA–miRNA–mRNA regulatory network in gastric cancer by analysis of microarray data

Identification of circRNA–miRNA–mRNA regulatory network in gastric cancer by analysis of microarray data

Effectiveness and Safety of Oral Chinese Patent Medicines Combined with Chemotherapy for Gastric Cancer: A Bayesian Network Meta-Analysis

The Role of Adjuvant Chemotherapy in the Treatment of Locally Advanced Gastric Cancer

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