Let M 1 and M 2 be closed connected orientable 3-manifolds. We classify the sets of smooth and piecewise linear isotopy classes of embeddings M 1 M 2 → S 6 . We start with the previously known classifications of E 6 (S 3 S 3 ) and E 6 (N ), where N is a closed connected orientable 3-manifold. These results are later used in our proofs. In §1.3 we also give a brief general survey on embeddings classification.An embedding g : S 3 → S 6 is called trivial if it is isotopic to the standard embedding. The isotopy class of a trivial embedding is also called trivial. The embedded connected sum operation # (see §1.4) defines a group structure on E 6 (S 3 ). Operation # also defines an action of E 6 (S 3 ) on E 6 (N ) for any closed connected orientable 3-manifold N . Theorem 1.1 (A. Haefliger). E 6 (S 3 ) ∼ = Z.I thank A. Skopenkov, M. Skopenkov, and U. Wagner for useful discussions. Supported in part by RFBR grant 15-01-06302. 1 In this paper "smooth" means C 1 -smooth. For each C ∞ -manifold N the forgetful map from the set of C ∞ -isotopy classes of C ∞ -embeddings N → R m to the set of C 1 -isotopy classes of C 1 -embeddings N → R m is a 1-1 correspondence, see [Zh16], c.f. [Sk15, footnote 2].