A Classic Twin Study of Isolated Gastroschisis

Schulz, Anna Carina; Stressig, R; Ritgen, J; Bağcı, Soyhan; Müller, Andreas; Gembruch, Ulrich; Geipel, A.; Berg, Christoph; Bartmann, Peter; Reutter, Heiko

doi:10.3109/15513815.2012.659393

Cited by 11 publications

(7 citation statements)

References 30 publications

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“…20 1 Spina bifida Q05.9 1 Congenital malformaƟons of lung Q33.9 1 Other encephaliƟs, myeliƟs och encephalomyeliƟs G04. 8 1 Acute pericardiƟs I30.9 1 AccidenƟal suffocaƟon and strangulaƟon in bed W75 1 Intrauterine hypoxia P20. 9 1…”

Section: Discussionmentioning

confidence: 99%

National birth prevalence, associated anomalies and mortality for gastroschisis in Sweden

et al. 2021

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Aim An increased incidence has been reported for the congenital abdominal wall defect gastroschisis. The reason for this increasing trend is not known, nor the aetiology. The aim of this study was to examine the national birth prevalence in Sweden, the termination rate, associated anomalies and the mortality of gastroschisis within the cohort. Methods A nationwide, population‐based descriptive study of children born with gastroschisis in Sweden between 1/1 1997 and 31/12 2016 was conducted. The cohort was collected from the Swedish Medical Birth Register and the Swedish National Patient Register. Several other national registers were then interlinked to identify outcome data. Results The study included 361 cases of gastroschisis, 54% female. The birth prevalence was 1.52 in 10,000 live births. The termination rate was 21%. The mortality within the cohort was 4.4% with a 1‐year mortality of 3.9%. Most frequent associated anomalies were gastrointestinal (11.4%), musculoskeletal (9.8%) and cardiovascular anomalies (7.9%). Conclusion During the 20‐year study period, a stable birth prevalence of 1.52 per 10 000 live births was seen in Sweden. The mortality was low, 4.4%, but the termination of pregnancies was high, 21%. Almost one‐third had associated congenital anomalies where gastrointestinal anomalies were the most common.

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Section: Discussionmentioning

confidence: 99%

National birth prevalence, associated anomalies and mortality for gastroschisis in Sweden

et al. 2021

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“…In a twin study, Schultz et al [2012] found that the concordance rate was not significantly different amongst dizygotic twins (4 out of 8 twins) compared to monozygotic twins (2 out of 5 twins reported). If we include our case with concordant gastroschisis, 3 out of 6 monozygotic twins are concordant, which is equal the concordance observed in dizygotic twins.…”

Section: Discussionmentioning

confidence: 88%

Mirror-image gastroschisis in monochorionic female twins

Lubala¹,

Mbuyi-Musanzayi²,

Lubala³

et al. 2015

European Journal of Medical Genetics

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“…The classic monozygotic (MZ)-dizygotic (DZ) twin comparison is an informative tool for investigating genetic and environmental influences on human health and behavior. Greater resemblance within MZ compared with DZ twin pairs is consistent with genetic components to the condition under study [1]. Studying MZ twins reared apart from birth (MZA) is an especially powerful variant of the classic twin design.…”

Section: Introductionmentioning

confidence: 94%

“…Identical twins doubly exchanged at birth: a case report of genetic and environmental influences on the adult epigenome Epigenomics (2017) 9 (1) future science group Case Report Segal, Montoya, Loke & Craig that epigenetic drift may be driven by discordance in the rearing environments of MZT pairs [12]. However, MZT and MZA pairs show comparable phenotypic similarity across a range of measures, including EEG, height, heart rate, blood pressure, electrodermal response, personality and well-being [13].…”

Section: Introductionmentioning

confidence: 99%