A circulating tumor cell cluster-based model for tumor metastasis (Hypothesis)

Hong, Yupeng; Li, Ziduo; Zhang, Qi

doi:10.3892/ol.2016.5358

Cited by 17 publications

(12 citation statements)

References 52 publications

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“…The most current CTC capture methods with antibodies detecting CTC surface proteins might be less efficient for CTC clusters as compared to single CTCs, possibly because antigens are largely masked by the CTC cluster nature itself. Thus, the real quantification of CTC clusters might be currently underestimated [9]. However, we will explore recent literature on CTC clusters and realize that their implication in cancer aggressiveness should not be neglected, as well as that they may even represent a valuable access to therapeutic optic.…”

Section: Introductionmentioning

confidence: 99%

Circulating Tumor Cell Clusters: United We Stand Divided We Fall

Amintas

Bedel

Moreau‐Gaudry

et al. 2020

IJMS

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The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor microemboli, in biological fluids has long been described. Intensive research on single CTCs has made a significant contribution in understanding tumor invasion, metastasis tropism, and intra-tumor heterogeneity. Moreover, their being minimally invasive biomarkers has positioned them for diagnosis, prognosis, and recurrence monitoring tools. Initially, CTC clusters were out of focus, but major recent advances in the knowledge of their biogenesis and dissemination reposition them as critical actors in the pathophysiology of cancer, especially metastasis. Increasing evidence suggests that “united” CTCs, organized in clusters, resist better and carry stronger metastatic capacities than “divided” single CTCs. This review gathers recent insight on CTC cluster origin and dissemination. We will focus on their distinct molecular package necessary to resist multiple cell deaths that all circulating cells normally face. We will describe the molecular basis of their increased metastatic potential as compared to single CTCs. We will consider their clinical relevance as prognostic biomarkers. Finally, we will propose future directions for research and clinical applications in this promising topic in cancer.

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Section: Introductionmentioning

confidence: 99%

Circulating Tumor Cell Clusters: United We Stand Divided We Fall

Amintas

Bedel

Moreau‐Gaudry

et al. 2020

IJMS

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“…The process of malignant tumor metastasis is very complex. It has been confirmed that the invasion of peripheral blood circulation by tumor cells is one of the main ways of distant metastasis dissemination ( 7 ). Circulating tumor cells (CTCs) are tumor cells found in the peripheral blood circulation, their shedding from the primary solid malignancy can be spontaneous or caused by medical treatment ( 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

Correlation between the presence of circulating tumor cells and the pathologic type and staging of non-small cell lung cancer during the early postoperative period

et al. 2017

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This study investigated possible correlations between the presence of circulating tumor cells (CTCs) and the pathologic types and staging of non-small cell lung cancer (NSCLC) during the early postoperative period. Sixty-nine patients with NSCLC were enrolled in the study. Clinical staging was performed by postoperative pathological examination and imaging. Multiple mRNA in situ analyses targeting specifically expressed genes were carried out to identify the presence of CTCs. Correlations between age, sex, TNM stage and pathological types with the detection rate of CTCs were also established. The results showed the positivity rate of CTCs in patients >55 years was significantly higher than that of patients <55 years (94.74 vs. 70.97%, P<0.05). There was no significant difference in the positivity rate of CTCs between male and female patients (85.71 vs. 85.29%, P>0.05). The correlations between the detection rate of epithelial type or mixed type CTCs with tumor size, lymph node metastasis and distant metastasis TNM in patients with NSCLC were not significant (P>0.05). However, higher TNM stages correlated with higher detection rates of mesenchymal CTCs (P<0.05). There were also significant differences in the detection rates of CTCs amongst the three different pathologic types (adenocarcinoma, squamous cell and large cell carcinomas) (P<0.05). Based on our results, the detection of mesenchymal CTCs during the early postoperative period can help prognosticate the recurrence and metastasis of NSCLC, which is beneficial to the development of individualized treatment strategies.

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“…Compared with CTCs, CTMs effectively reflected the severity of illness and dismal prognosis of patients in our study. Although CTCs have been found in many studies, only a few successful detections of CTC clusters have been reported, especially in PDAC patients (29). We believe that the role of CTMs in current clinical applications and research is largely underestimated.…”

Section: Univariate Analysis ---------------------------------------mentioning

confidence: 93%

Prognostic significance of circulating tumor microemboli in patients with pancreatic ductal adenocarcinoma

Zhu

et al. 2018

Oncol Lett

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The significance of circulating tumor microemboli (CTMs) in patients with pancreatic ductal adenocarcinoma (PDAC) is still unknown. Thus, the present study used a epithelial cellular adhesion molecule independent subtraction and immunostaining-fluorescence hybridization (SET-iFISH) platform to enumerate circulating tumor cells (CTCs) and CTMs in a total of 86 peripheral blood samples from 19 patients with PDAC. The associations between CTCs and CTMs with clinicopathologic factors and prognoses were analyzed. Prior to treatment, CTCs were detected in all 19 patients, and CTMs were detected in 4 patients with different tumor-node-metastasis (TNM) stages. A total of 85 of the 86 peripheral blood samples had cytokeratin 18-negative CTCs. The number of CTCs and CTMs were significantly associated with tumor size and vascular invasion. Patients with CTMs had poorer overall survival and disease-free survival when compared with those without CTMs (7.3 vs. 25.40 months, P=0.001; and 1.80 vs. 18.97 months, P=0.037). The presence of CTMs in the peripheral blood prior to surgery was predictive of poor prognosis in PDAC patients. CTMs could be detected in patients of different TNM stage (II, III and IV). Surgery did not benefit patients with CTMs, thus, surgeons should take greater consideration when assessing the requirements for surgery in patients with CTMs.

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A circulating tumor cell cluster-based model for tumor metastasis (Hypothesis)

Cited by 17 publications

References 52 publications

Circulating Tumor Cell Clusters: United We Stand Divided We Fall

Circulating Tumor Cell Clusters: United We Stand Divided We Fall

Correlation between the presence of circulating tumor cells and the pathologic type and staging of non-small cell lung cancer during the early postoperative period

Prognostic significance of circulating tumor microemboli in patients with pancreatic ductal adenocarcinoma

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