A chronic unit study of the sensory properties of neurons in the forelimb areas of rat sensorimotor cortex

Sievert, Carl; Neafsey, Edward J.

doi:10.1016/0006-8993(86)90684-0

Cited by 51 publications

(32 citation statements)

References 35 publications

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“…The mediolateral and anteroposterior distribution of the recording/injection sites in the cortex confirmed the global somatotopic maps shown by others in rat (Hall and Lindholm, 1974;Chapin and Lin, 1984;Welker et al, 1984;Sievert and Neafsey, 1986). The cells at the injection sites had cutaneous receptive fields, like those described by Welker et al (1984), Simons (1978), and Chapin (1986), who also confirmed a globally somatotopic and columnar organization of functionally related cells in rat somatosensory cortex.…”

Section: Characteristics Of the Cortical Injection Sitesupporting

confidence: 85%

Organizing principles of cortical integration in the rat neostriatum: Corticostriate map of the body surface is an ordered lattice of curved laminae and radial points

1998

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The neuroanatomic organizing principles underlying integrative functions in the striatum are only partially understood. Within the three major subdivisions of the striatum-sensorimotor, associative, and limbic--longitudinal zones of axonal plexuses from the cerebral cortex end in bands and clusters that innervate cell groups. To identify organizing principles of the corticostriate bands and clusters, we localized somatosensory cortical cells receptive to light touch on the hindlimb, forelimb, or vibrissae by extracellular recording, and we labeled their projections by iontophoretic application of dextran anterograde tracers. The results show that cortical cells in columnar groups project to the striatum in the form of successive strips, or laminae, that parallel the curve of the external capsule. The vibrissae somatosensory cortex projects to the most lateral lamina. Just medial to the vibrissae projection, the major axonal arborizations arising from hindlimb and forelimb somatosensory cortex are organized within a common lamina, where they interdigitate and overlap as well as remain separate. In addition, the hindlimb and forelimb cortex send small projections to the vibrissae lamina, and vice versa, forming broken, radially oriented lines of points across the laminar strips. The major somatosensory projections are in the dorsolateral, calbindin-poor sensorimotor striatum, whereas the radially oriented projection points extend into the medial, calbindin-rich associative striatum. Extending previous studies of corticostriate projections, this report shows a grid translation of columnar somatosensory cortical inputs into striatum and a detailed map for the rat sensorimotor zone. The lattice-like grid is a novel functional/neuroanatomic organization that is ideal for distributing, combining, and integrating information for sensorimotor and cognitive processing.

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Section: Characteristics Of the Cortical Injection Sitesupporting

confidence: 85%

Organizing principles of cortical integration in the rat neostriatum: Corticostriate map of the body surface is an ordered lattice of curved laminae and radial points

1998

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“…Conventionally, single intracortical microelectrodes are used to measure responses evoked by peripheral nerve stimulation (Hall and Lindholm, 1974;Chapin and Lin, 1984;Sievert and Neafsey, 1986;Xerri et al, 1996). These techniques allow for a detailed mapping of somatosensory representations, but are limited by long durations of the experimental procedure with the risk of confounding effects of time, and by inconstant electrode positioning in repeated mappings.…”

Section: Introductionmentioning

confidence: 99%

“…The rodent sensorimotor cortex is an important target area for studies on cortical anatomy and physiology (Hall and Lindholm, 1974;Killackey, 1983;Chapin and Lin, 1984). In the rat, somatosensory and motor cortices are in close proximity and partially overlap (Hall and Lindholm, 1974;Killackey, 1983;Sievert and Neafsey, 1986). Both cortices interact to enable movement and motor learning (Xerri et al, 1996;Asanuma and Pavlides, 1997).…”

Section: Introductionmentioning

confidence: 99%

Thin-film epidural microelectrode arrays for somatosensory and motor cortex mapping in rat

Hosp

Molina-Luna

Hertler

et al. 2008

Journal of Neuroscience Methods

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“…The reduced glabrous skin representation observed in both HG and HGn Ϫ rats more likely reveals a redistribution of effective inputs within these cortical sectors of the forepaw maps due to the HG environment. The dynamic balance between competing inputs distributed within thalamocortical and intracortical networks is underpinned by the convergence of cutaneous and proprioceptive inputs onto single layer IV neurons of the S1 cortex (Chapin and Lin 1984;Gioanni 1987;Lamour and Jobert 1982;Sievert and Neafsey 1986). This convergence enables an experience-dependent, behaviorally relevant allocation and refinement of somatosensory cortex representational territories.…”

Section: Summary Of Resultsmentioning

confidence: 99%

Hypergravity within a critical period impacts on the maturation of somatosensory cortical maps and their potential for use-dependent plasticity in the adult

Zennou-Azogui

Catz

Xerri

2016

Journal of Neurophysiology

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Zennou-Azogui Y, Catz N, Xerri C. Hypergravity within a critical period impacts on the maturation of somatosensory cortical maps and their potential for use-dependent plasticity in the adult. J Neurophysiol 115: 2740 -2760, 2016. First published February 17, 2016 doi:10.1152/jn.00900.2015.-We investigated experience-dependent plasticity of somatosensory maps in rat S1 cortex during early development. We analyzed both short-and long-term effects of exposure to 2G hypergravity (HG) during the first 3 postnatal weeks on forepaw representations. We also examined the potential of adult somatosensory maps for experience-dependent plasticity after early HG rearing. At postnatal day 22, HG was found to induce an enlargement of cortical zones driven by nail displacements and a contraction of skin sectors of the forepaw map. In these remaining zones serving the skin, neurons displayed expanded glabrous skin receptive fields (RFs). HG also induced a bias in the directional sensitivity of neuronal responses to nail displacement. HG-induced map changes were still found after 16 wk of housing in normogravity (NG). However, the glabrous skin RFs recorded in HG rats decreased to values similar to that of NG rats, as early as the end of the first week of housing in NG. Moreover, the expansion of the glabrous skin area and decrease in RF size normally induced in adults by an enriched environment (EE) did not occur in the HG rats, even after 16 wk of EE housing in NG. Our findings reveal that early postnatal experience critically and durably shapes S1 forepaw maps and limits their potential to be modified by novel experience in adulthood. cortex; development; critical period; electrophysiological mapping; forepaw EXPERIENCE-DEPENDENT SHAPING of morphological and functional brain circuits leads to appropriately organized neural networks that subserve adult brain functions. The effect of the so-called epigenetic factors is most prominent within postnatal

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A chronic unit study of the sensory properties of neurons in the forelimb areas of rat sensorimotor cortex

Cited by 51 publications

References 35 publications

Organizing principles of cortical integration in the rat neostriatum: Corticostriate map of the body surface is an ordered lattice of curved laminae and radial points

Organizing principles of cortical integration in the rat neostriatum: Corticostriate map of the body surface is an ordered lattice of curved laminae and radial points

Thin-film epidural microelectrode arrays for somatosensory and motor cortex mapping in rat

Hypergravity within a critical period impacts on the maturation of somatosensory cortical maps and their potential for use-dependent plasticity in the adult

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