A chromatography-free synthesis of racemic salbutamol hemisulfate

Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform

“…[2] The common bioactive fragment of Salbutamol and Salmeterol is an aryl vicinyl amino alcohol (Figure 1a), the synthesis of which is potentially challenging due to high hydrophilicity of the reaction intermediates and product. [3] Researchers at GSK have designed a strategy that instead utilizes surrogate (R)-1 as convenient entry for the synthesis of (R)-Salmeterol and other β 2 -adrenoceptor agonists. [4] The method described for the preparation of (R)-1 is a lengthy 9-step synthesis.…”