A chromatographic survey of polyphenols from Salvia species

Adzet, T.; Caiñigueral, S.; Iglesias, José

doi:10.1016/0305-1978(88)90113-5

Cited by 25 publications

(7 citation statements)

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“…On the other hand, there are some other review articles that describe the phytochemicals in specific species or those belonging to some limited geographical regions. For instance, bi-and tri-cyclic diterpenoids (Bonito et al 2011), triterpenoids (Topçu 2006) and polyphenols (Adzet et al 1988;Lu and Yeap Foo 2002) from the genus Salvia or the bioactive secondary metabolites from Tanshen; S. miltiorrhiza (Wang 2010) have been reviewed. Recently, the anticholinesterase, neuroprotective, anticancer, antiviral, anti-inflammatory, and antioxidant activities of Salvia L. were summarized in a review paper (Dziurzynski et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Bioactive phytochemicals from shoots and roots of Salvia species

et al. 2015

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The plants of the genus Salvia L. are important medicinal herbs of the Lamiaceae family and some of them such as S. officinalis (sage), S. miltiorrhiza (red sage, Danshen) and S. sclarea (clary sage) have been used as medicinal plants in the folk medicine of several countries. In this review, we discuss the reports that have examined Salvia species with the aim of isolation of pure compounds with different biological activities. The phytochemical analyses of various sage plants have reported 10 monoterpenoids (1-10), 1 sesquiterpenoid (11), 8 labdane (13-20), 15 ent-kaurane (21-35), 82 abietane, rearranged abietane and tanshinone (36-117), 3 icetexane (118-120), 43 clerodane (121-163), and 3 pimarane (164-166) diterpenoids with cytotoxic and antimicrobial, antiprotozoal, antioxidant, phytotoxic and insecticide effects. The other heavier terpenoids, including 3 sesterterpenes (167-169), 10 triterpenoids and b-sitosterol (170-180) have been introduced as minor bioactive compounds in the sage plants. Sahandinone (107), 6,7-dehydroroyleanone, 7-a-acetoxyroyleanone (40), and tanshinone like diterpenoids have been isolated from the roots' extracts of different Salvia species. On the other hand, several radical scavenger phenolic compounds like simple phenolics and caffeic acid derivatives (181-201) including rosmarinic acid, flavonoids (202-217) as well as phenolic diterpenoids, such as carnosol and carnosic acid have been isolated from the aerial parts of these plants. One pyrrole (218) and 3 antimicrobial oxylipins (219-221) are among the other less detected constituents in the members of Salvias. Furthermore, sages also synthesize antifungal, antileishmanial and antimalarial phytochemicals in their roots and shoots, which are reviewed in this paper. We also examine the allelopathic phenomena and the ecologically important phytochemicals identified in different parts of the sage plants. Finally, antifeedant and insecticide phenomena, which are due to the presence of volatile monoterpenes and clerodane diterpenes in these plants, are discussed. Considering the presence of diverse biologically active phytochemicals in the sage plants, they can be suggested as suitable candidates for the formulation of valuable natural medicines.

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Section: Introductionmentioning

confidence: 99%

Bioactive phytochemicals from shoots and roots of Salvia species

et al. 2015

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“…The most effective bioactive components of sage are monoterpenes: borneol, bornyl acetate, α-pinene, β-pinene, α-thujone, β-thujone, eucalyptol, myrcene etc. (Bernáth et al, 1991;Di Cesare et al, 2001, Couladis et al, 2002, flavonoids [Cuvelier et al, 1994;1996, Wang et al, 1998Miura et al, 2002) and other polyphenolic components (Adzet et al, 1987;Lu and Foo, 1999, 2000, Ho et al, 2000. Hardly any investigations were made to determine the metal ion content of sage (Azhabov et al, 1998;Then and Szentmihályi, 1998), although a closer knowledge of the quality and quantity of the metal content would be essential, with special regard to the application of 124 sage in medicine and in cosmetics.…”

Section: Introductionmentioning

confidence: 99%

Polyphenol-, Mineral Element Content and Total Antioxidant Power of Sage (Salvia Officinalis L.) Extracts

Then¹,

Vásárhelyi-Perédi²,

Szöllosy³

et al. 2004

Acta Hortic.

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The alcoholic extracts of Salvia officinalis L. leaves were studied for element composition, polyphenol content and antioxidant property. The procedure of the alcoholic extract preparation was different from the conventional tincture preparing and it was amplified with extraction in ultrasonic water bath. The plant material was treated (infused) with the water proportion of the tincture-solvent (alcoholic solution of 20 %), then the alcohol-part (of tincture-solvent) was added to the cooled aqueous extract. Element concentrations of the samples were determined by inductively coupled plasma atomic emission spectrometry. The phenol carbonic acid (rosmarinic-, caffeic-, chlorogenic-and ferulic acid) content was measured by HPLC. The highest amount of caffeic acid (5.3 µg 100mL-1) and ferrulic acid (2.6 µg 100mL-1) were observed in macerated extracts made from 5 g leaves with 20 % alcohol, while the highest amount of rosmarinic acid (25.2 µg 100mL-1) was measured in ultrasonic extract. The mineral element content showed significant differences in the extracts prepared in diverse ways. The macerated extract, prepared by 40 % alcohol, showed the highest tannin-(266 mg 100mL-1) and polyphenol content (394 mg 100mL-1), the conventional tincture contained 166 mg 100mL-1 of tannin and 200 mg 100mL-1 of polyphenol. The flavonoid content was 58 mg/ 100mL in conventional alcoholic extract and 136 mg 100mL-1 in infused extract. The total antioxidant power was found to be significantly different in the different extracts which was measured by the FRAP assay.

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“…Salvia officinalis L. (Lamiaceae), commonly known as sage, is cultivated throughout the world for its culinary properties, essential (volatile) oil and aromatic chemicals. However, it is also rich in polyphenolic secondary metabolites, which are thought to be responsible for its potent antioxidative and medicinal properties [1][2][3]. As part of our ongoing phytochemical and antioxidantrelated investigations of the Lamiaceae family, we have determined the total phenolic content, qualitativequantitative composition and in vitro antioxidant-related properties of a crude extract and selected fractions isolated of S. officinalis.…”

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confidence: 99%

Salvia Officinalis L.: Composition and Antioxidant-related Activities of a Crude Extract and Selected Sub-fractions

Koşar

Dorman

Başer

et al. 2010

Natural Product Communications

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The composition and antioxidant properties of a methanol: acetic acid (99:1, v/v) soluble crude extract isolated from S. officinalis L. leaves through maceration and selected fractions isolated thereof are presented in this study. The total phenol content was estimated as gallic acid equivalents, whilst qualitative-quantitative phenolic content was determined using high performance liquid chromatography with photodiode array detection. Antioxidant evaluation consisted of ferric reductive capacity and 1,1-diphenyl-2-picrylhydrazyl and hydroxyl free radical scavenging determinations. The crude extract contained hydroxybenzoic acids, hydroxycinnamic acids, flavonoids and diterpenoids, whilst caffeic acid, carnosic acid, luteolin, luteolin-7-O-glucoside and rosmarinic acid were identified from their chromatographic and spectral characteristics and quantified from their respective calibration curves. The crude extract and sub-fractions demonstrated varying degrees of efficacy in the antioxidant-related assays used, except the n-hexane fraction, which was unable to reduce iron(III) at reasonable concentrations. Although the positive controls, ascorbic acid, BHA and BHT, were more potent than the S. officinalis samples, two fractions were significantly (p < 0.05) more potent iron(III) reducing agents than pycnogenol, a proanthocyanidin-rich commercial preparation.

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A chromatographic survey of polyphenols from Salvia species

Cited by 25 publications

References 10 publications

Bioactive phytochemicals from shoots and roots of Salvia species

Bioactive phytochemicals from shoots and roots of Salvia species

Polyphenol-, Mineral Element Content and Total Antioxidant Power of Sage (Salvia Officinalis L.) Extracts

Salvia Officinalis L.: Composition and Antioxidant-related Activities of a Crude Extract and Selected Sub-fractions

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