A chromatographic method of determining serum kallikrein and prekallikrein levels in dogs

Dotsenko, V.L.; Sayapin, V. N.; Neshkova, Elena; Yarovaya, G. A.

doi:10.1007/bf00830745

Cited by 1 publication

(1 citation statement)

References 2 publications

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“…For instance, blockade of ACE by the respective inhibitors in type I diabetes patients results in blood pressure decrease, as well as in enhanced uptake of glucose by peripheral tis sues and elimination of insulin tolerance due to the insulin like effects of bradykinin [50,80,99,100]. It is well known that several biological processes, including hemostasis, water and salt balance, and a range of functions of the gastrointestinal tract and the reproductive system, may be impaired due to the effects of inflammation and pain; the latter phenom ena, in their turn, rely on KKS activation and bradyki nin formation.…”

Section: Kininasesmentioning

confidence: 99%

Past and present research on the kallikrein-kinin system (on the 90th anniversary of the discovery of the system)

Yarovaya

Neshkova

2015

Russ J Bioorg Chem

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The kallikrein-kinin system (KKS) is the key proteolytic system participating in control of a wide spectrum of physiological functions and the development of many pathological conditions. This explains great interest in structures, functions and molecular biology of separate components of the system, molecular mechanisms of their interaction and relationship with other regulatory systems. The information in this field for the last two decades clarifies the role of KKS in morphogenesis of cells, regulation of smooth muscular contractility of some organs, decrease of blood pressure, increase of vascular permeability, the development of inflammation, transformation of cells and the other functions of both physiological and pathological processes. Essential progress in understanding of functions KKS was made by the discovery and study of bradykinin receptors, cloning of kininogen and kallikrein encoding genes, revealing of domain structure of kininogen, prekallikrein and some kininases and decoding of mechanisms of contact phase of proteolytic system activation in blood plasma.

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Section: Kininasesmentioning

confidence: 99%