Abstract:Generalization formation and extinction of aversion are associated with affective disorders, but little is known about underlying mechanisms. Here, we established a novel procedure for induction of visual aversion by dynamic stripe images on digital screens in mice. We found that decreased activity of medial septum (MS) cholinergic neurons led to generalization aversion loss, but didn't affect its extinction. We identified a new projection from MS cholinergic neurons to medial habenula (MHb), and found that in… Show more
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