A chlorogenic acid-phospholipid complex ameliorates post-myocardial infarction inflammatory response mediated by mitochondrial reactive oxygen species in SAMP8 mice

Li, Yi; Ren, Xuecong; Lio, Chon-Kit; Sun, Weijian; Lai, Ke; Liu, Yuan; Zhang, Zhifeng; Liang, Jie; Zhou, Hua; Liu, Liang; Huang, Hui; Ren, Jing; Luo, Pei

doi:10.1016/j.phrs.2018.01.006

Cited by 38 publications

(21 citation statements)

References 31 publications

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“…CGA is a bioactive polyphenolic compound that scavenges ROS, alleviates oxidative damage, ameliorates inflammatory response in liver injury, diabetic retinopathy, inflammatory intestinal diseases, etc. [21,22]. In this study, it is shown from the results that CGA treatment significantly increased IPL thickness and RGC viability, and significantly reduced ROS level and RGC apoptosis, which suggested that CGA exerted an antioxidative effect in the treatment of glaucoma.…”

Section: Discussionmentioning

confidence: 53%

Chlorogenic acid relieved oxidative stress injury in retinal ganglion cells through IncRNA-TUG1/Nrf2

Gong

Zhu

et al. 2019

Cell Cycle

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Objective: To discover the possible underlying mechanism of Chlorogenic acid (CGA) in protecting against oxidative stress injury in glaucoma. Methods: LncRNA TUG1 and Nrf2 expressions were detected by qRT-PCR and Western blot. Retinal ganglion cell (RGC) viability and apoptosis were measured by MTT and flow cytometry, respectively. Reactive oxygen species (ROS) level was determined by reactive oxygen species assay kit. The interaction between lncRNA TUG1 and Nrf2 was confirmed by RNA pull-down and RIP assay. Results: IPL thickness and lncRNA TUG1 expression were significantly decreased in glaucoma mice model, and CGA treatment increased IPL thickness and lncRNA TUG1 expression. In vitro H2O2induced RGCs, RGC viability was significantly decreased, and ROS level and cell apoptosis were significantly increased. CGA up-regulated lncRNA TUG1 and Nrf2 expressions, decreased cell apoptosis and ROS production in RGCs, and increased RGCs viability. We further verified the interaction between lncRNA TUG1 and Nrf2, and proved Nrf2 was positively regulated by lncRNA TUG1. We found CGA promoted Nrf2 expression through lncRNA-TUG1, and further verified CGA protected RGCs from oxidative stress through regulating lncRNA TUG1/Nrf2. In vivo experiments showed TUG1 knockdown abrogated therapeutic effect of CGA on glaucoma. Conclusion: CGA increased RGC viability and decreased ROS level and RGC apoptosis after oxidative stress injury through lncRNA TUG1/Nrf2 pathway, which protected against glaucoma.

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Section: Discussionmentioning

confidence: 53%

Chlorogenic acid relieved oxidative stress injury in retinal ganglion cells through IncRNA-TUG1/Nrf2

Gong

Zhu

et al. 2019

Cell Cycle

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“…While TNF-α alone increased mPTP and protein expression of cleaved caspase-3 (activated), chlorogenic acid pretreatment completely blunted these effects, which corresponded to a significant attenuation in TNF-α-induced apoptosis. In vivo, senescence-accelerated prone 8 (SAMP8) mice (mice with accelerated aging) at 10 months of age received chlorogenic acid bound to a phospholipid complex (to increase absorption) at 10 or 20 mg/kg/day for two weeks [178]. Following treatment, I/R injury was induced, after which animals were immediately sacrificed.…”

Section: Role Of Polyphenols In Cardiac Mitochondrial Dysfunctionmentioning

confidence: 99%

Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential

Najjar

Feresin

2021

IJMS

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Heart failure (HF) is a leading cause of death in the United States, with a 5-year mortality rate of 50% despite modern pharmacological therapies. Plant-based diets are comprised of a diverse polyphenol profile, which lends to their association with reduced cardiovascular disease risk. Whether a polyphenol-rich diet can slow the progression of or reverse HF in humans is not known. To date, in vitro and in vivo studies have reported on the protective role of polyphenols in HF. In this review, we will discuss the major mechanisms by which polyphenols mitigate HF in vitro and in vivo, including (1) reduced cardiac inflammation and oxidative stress, (2) reduced mitochondrial dysfunction, (3) improved Ca2+ homeostasis, (4) increased survival signaling, and (5) increased sirtuin 1 activity.

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“…Phospholipid complex is now widely used in pharmaceutics to enhance drug solubility and ability of penetrating cell membranes for poorly water-soluble drug. [17] The mechanism of formation of phospholipid complex has been confirmed by electrostatic attraction or/and the intermolecular forces of drugs and phospholipids. [18] The combination of poorly soluble drug and phospholipid complex carrier system can increase the drug's dissolution and retard the drug release, meanwhile improve the drug oral absorption in the gastrointestinal tract and oral bioavailability, since phospholipids are both amphiphilic and an important constituent of biomembrane.…”

Section: Introductionmentioning

confidence: 98%

“…Phospholipid complex is now widely used in pharmaceutics to enhance drug solubility and ability of penetrating cell membranes for poorly water‐soluble drug . The mechanism of formation of phospholipid complex has been confirmed by electrostatic attraction or/and the intermolecular forces of drugs and phospholipids .…”

Section: Introductionmentioning

confidence: 99%

Preparation and preliminary pharmacokinetics study of GNA-loaded zein nanoparticles

Cheng

Wang

Zhang

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Gambogenic acid (GNA), one of the main active ingredients isolated from Garcinia cambogia, has shown diverse antitumour activities. However, short biological half‐life and low oral bioavailability severely limit its clinical application. Here, we developed GNA‐loaded zein nanoparticles (GNA‐ZN‐NPs) based on phospholipid complex and zein nanoparticles to prolong the circulation time and enhance oral bioavailability of GNA. Methods The physicochemical properties of GNA‐ZN‐NP were characterized in details. The in vitro release profile, in vivo pharmacokinetic experiments and tissue distribution of GNA‐ZN‐NPs were also evaluated. Key findings The particle size, PDI and encapsulation efficiency of GNA‐ZN‐NPs were 102.90 nm, 0.027 and 76.35 ± 0.64%, respectively. The results of SEM, FTIR, DSC and XRD demonstrated that GNA‐ZN‐NPs were prepared successfully. The in vitro dissolution of GNA‐ZN‐NPs exhibited controlled release compared with raw GNA solution. The pharmacokinetic study showed that the AUC of GNA‐ZN‐NPs was significantly increased, and the t1/2 and MRT values of GNA‐ZN‐NPs were 3.21‐fold and 2.19‐fold higher than that of GNA solution. Tissue distribution results illustrated that GNA‐ZN‐NPs showed hepatic‐targeting properties. Conclusion GNA‐ZN‐NPs significantly enhanced the oral bioavailability and prolonged half‐life of GNA, providing a promising oral drug delivery system to improve in vivo pharmacokinetic behaviour of GNA.

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A chlorogenic acid-phospholipid complex ameliorates post-myocardial infarction inflammatory response mediated by mitochondrial reactive oxygen species in SAMP8 mice

Cited by 38 publications

References 31 publications

Chlorogenic acid relieved oxidative stress injury in retinal ganglion cells through IncRNA-TUG1/Nrf2

Chlorogenic acid relieved oxidative stress injury in retinal ganglion cells through IncRNA-TUG1/Nrf2

Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential

Preparation and preliminary pharmacokinetics study of GNA-loaded zein nanoparticles

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