A chlorin e6 derivative‐mediated photodynamic therapy for patients with cervical and vaginal low‐grade squamous intraepithelial lesions: a retrospective analysis

Abstract

Cervical and vaginal low‐grade squamous intraepithelial lesions (LSIL) are associated with persistent human papillomavirus infections, and require an efficacious non‐invasive treatment such as photodynamic therapy due to anatomical characteristics. In this study, we evaluated the clinical efficacy and safety of a chlorin e6 derivative named STBF‐mediated photodynamic therapy (STBF‐PDT) for patients with cervical and vaginal LSIL. A total of 18 patients received STBF‐PDT for 3 to 6 times and followed up for 6 to 12 months; among them, 6 had cervical and vaginal LSIL and 1 had vaginal stump LSIL after hysterectomy for cervical cancer. Results showed the complete remission (CR) rates were 72.22% (13/18), and the HPV remission rates and HPV clearance rates were 88.89% (16/18) and 83.33% (15/18), respectively at 1‐month follow‐up. The CR reached 88.89% and HPV remission rates got 94.44% at the 6‐month follow‐up. There were no recurrence cases so far, and no pain, heaving sensation, scar, deformity, and any other obvious adverse reactions occurred during treatment and follow‐up. In conclusion, STBF‐PDT is an effective, safe, and well‐tolerated method for the treatment of cervical and vaginal LSIL. It may have promising potential for applications in the future.

Photodynamic therapy of cervical cancer: a scoping review on the efficacy of various molecules

“…(F) Chlorin e6: Another photosensitizer used in PDT for cervical cancer. 45 It exhibits a high absorption rate in the near-infrared region, enabling deeper tissue penetration compared to other photosensitizers. Chlorin e6 has also demonstrated high selectivity for cancer cells over healthy cells, making it a promising candidate for PDT.…”

Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp.

“…A Ce6-derivative obtained from Spirulina sp. was evaluated as a PS for the treatment of cervical and vaginal low-grade squamous intraepithelial lesions (LSIL), associated with persistent human papillomavirus (HPV) infections [ 148 ]. The results showed that the complete remission rates were 88.89% and the HPV remission rates was 94.44% at a 6-month follow-up.…”

Translation of photodynamic therapy and photodiagnostics into the clinic: Status and obstacles

“…The manuscript by Yao et al [6] reports on an oncological clinical study on chlorin e6 derivative mediated PDT treatments on 18 patients with cervical and vaginal low-grade squamous intraepithelial lesions. Very high rates of complete response and HPV remission were observed at the 6-month follow-up, higher than achieved, for example, with ALA-induced PpIX as reported recently [7,8].…”