A chitosan modified asymmetric small-diameter vascular graft with anti-thrombotic and anti-bacterial functions for vascular tissue engineering

Wang, Yilin; He, Chao; Feng, Yunbo; Yang, Yuliang; Wei, Zhiwei; Zhao, Weifeng; Zhao, Changsheng

doi:10.1039/c9tb01755k

Cited by 47 publications

(31 citation statements)

References 76 publications

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“…For the scaffold fabrication, the electrospinning technology was utilized [127]. The results of this study showed that the PCL/Ch hybrid-based SDVGs have similar anti-thrombogenic properties as the heparin-coated vessel conduits, while the bacterial killing ratios were 64% for S. aureus and 73% E. coli [127]. Yao et al [129] also developed electrospun PCL/Ch SDVGs, which were further combined with heparin and referred as Hep-PC/Ch grafts.…”

Section: Biopolymersmentioning

confidence: 88%

“…The production of vascular grafts made of chitosan has also been reported [127]. Chitosan is a linear polysaccharide that is closely related to sulfated glycosaminoglycans (sGAGs) [128].…”

Section: Biopolymersmentioning

confidence: 99%

“…In the context of vascular graft production, the electrospinning technology can be utilized to produce conduits with wide pore distribution, high porosity, and adequate microenvironment for cell adhesion and proliferation. Wang et al [127] reported the development of a PCL/chitosan (PCL/Ch) hybrid-based SDVG with anti-thrombogenic and anti-bacterial properties. For the scaffold fabrication, the electrospinning technology was utilized [127].…”

Section: Biopolymersmentioning

confidence: 99%

“…Wang et al [127] reported the development of a PCL/chitosan (PCL/Ch) hybrid-based SDVG with anti-thrombogenic and anti-bacterial properties. For the scaffold fabrication, the electrospinning technology was utilized [127]. The results of this study showed that the PCL/Ch hybrid-based SDVGs have similar anti-thrombogenic properties as the heparin-coated vessel conduits, while the bacterial killing ratios were 64% for S. aureus and 73% E. coli [127].…”

Section: Biopolymersmentioning

confidence: 99%

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Future Perspectives in Small-Diameter Vascular Graft Engineering

et al. 2020

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The increased demands of small-diameter vascular grafts (SDVGs) globally has forced the scientific society to explore alternative strategies utilizing the tissue engineering approaches. Cardiovascular disease (CVD) comprises one of the most lethal groups of non-communicable disorders worldwide. It has been estimated that in Europe, the healthcare cost for the administration of CVD is more than 169 billion €. Common manifestations involve the narrowing or occlusion of blood vessels. The replacement of damaged vessels with autologous grafts represents one of the applied therapeutic approaches in CVD. However, significant drawbacks are accompanying the above procedure; therefore, the exploration of alternative vessel sources must be performed. Engineered SDVGs can be produced through the utilization of non-degradable/degradable and naturally derived materials. Decellularized vessels represent also an alternative valuable source for the development of SDVGs. In this review, a great number of SDVG engineering approaches will be highlighted. Importantly, the state-of-the-art methodologies, which are currently employed, will be comprehensively presented. A discussion summarizing the key marks and the future perspectives of SDVG engineering will be included in this review. Taking into consideration the increased number of patients with CVD, SDVG engineering may assist significantly in cardiovascular reconstructive surgery and, therefore, the overall improvement of patients’ life.

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Section: Biopolymersmentioning

confidence: 88%

“…The production of vascular grafts made of chitosan has also been reported [127]. Chitosan is a linear polysaccharide that is closely related to sulfated glycosaminoglycans (sGAGs) [128].…”

Section: Biopolymersmentioning

confidence: 99%

Section: Biopolymersmentioning

confidence: 99%

Section: Biopolymersmentioning

confidence: 99%

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Future Perspectives in Small-Diameter Vascular Graft Engineering

et al. 2020

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“…5,6 Tissue engineering scaffolds may effectively overcome the above defects. 7 In order to promote cell adhesion, migration, proliferation and mimic the extracellular matrix (ECM) 8 of native nanofibers and avoid side effects such as chronic inflammation and complement cascade initiation, 9 it is crucial to choose of appropriate materials when fabrication the tissue engineering scaffolds. [10][11][12][13] An ideal biomaterial for tissue engineering scaffolds should present excellent biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Development of an electrospun polycaprolactone/silk scaffold for potential vascular tissue engineering applications

Liu

Chen

et al. 2020

Journal of Bioactive and Compatible Polymers

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Long-distance (⩾10 mm) arterial vascular defect injury was a massive challenge affecting human health. Compared with autologous transplantation, tissue-engineered scaffolds such as biocompatible silk fibroin (SF) scaffolds have been developed because they exhibit equivalent functional repair effects without adverse reactions. However, its mechanical strength and structural stability needed to be further improved to match the longer repair cycle of blood vessels while maintaining the original biological safety. Hence, we designed and prepared SF and hydrophobic polycaprolactone (PCL) composite microfibers by an improving electrospinning method. It was found that when the weight ratio of PCL to SF was 1: 1, a microfiber scaffold with high strength (6.16 N) and minimum degradability can be obtained. More importantly, compared with natural silk fibroin, the novel composite microfiber scaffolds can slightly inhibit cell infiltration and inflammation through co-culture with HUVECs in vitro and rabbit back transplantation in vivo. Furthermore, the fabricated scaffolds also demonstrated excellent structural stability in vivo because of the well-organized PCL doping in the structure. All these results indicated that the novel PCL/SF composite microfiber scaffolds were promising candidates for vascular tissue engineering applications.

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Organic Feedstock as Biomaterial for Tissue Engineering

Klanrit

2022

High‐Performance Materials From Bio‐based Feedstocks

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A chitosan modified asymmetric small-diameter vascular graft with anti-thrombotic and anti-bacterial functions for vascular tissue engineering

Abstract: Rapid endothelialization and prevention of restenosis are two vital challenges for the preparation of a small-diameter vascular graft (SDVG), while postoperative infection after implantation is often neglected.

Cited by 47 publications

References 76 publications

Future Perspectives in Small-Diameter Vascular Graft Engineering

Future Perspectives in Small-Diameter Vascular Graft Engineering

Development of an electrospun polycaprolactone/silk scaffold for potential vascular tissue engineering applications

Organic Feedstock as Biomaterial for Tissue Engineering

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