A chitosan hydrogel-thickened nanoemulsion containing Pelargonium graveolens essential oil for treatment of vaginal candidiasis

Santos, Maíra Kerpel dos; Kreutz, Tainá; Danielli, Letícia Jacobi; Marchi, João Guilherme Barreto De; Pippi, Bruna; Koester, Letícia Scherer; Limberger, Renata Pereira

doi:10.1016/j.jddst.2020.101527

Cited by 35 publications

(29 citation statements)

References 35 publications

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“…Furthermore, the essential oils, e.g., tea tree oil, eucalyptus oil, geranium oil, mint essential oil from M. spicata var. virdis and lemongrass oil, can act as multifunctional excipients due to their antimicrobial properties [ 93 , 94 , 95 , 96 ].…”

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

“…An example of the beneficial effect of ethylene glycol used as a cosurfactant in combination with the Cremophor EL in microemulsions and nanoemulsions with ethyl oleate as an oil phase is the achievement of a twofold reduction of the inner phase droplet size and a significant reduction of PDI compared to formulations obtained without the addition of the cosurfactant [ 116 , 117 ]. The commonly used cosurfactants in the EVDF include ( Table 3 ): short-chain mono- and polyhydric alcohols [ 79 , 83 , 85 , 86 , 90 , 92 , 98 ], soybean phosphatidylcholine [ 75 ], fatty acids and fatty acid esters [ 91 , 105 ], polyethylene glycols and their derivatives [ 74 , 94 , 95 , 99 , 105 ] and polysorbates [ 78 , 93 , 97 ].…”

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

“…In emulsion-based vaginal dosage forms several other excipients such as gelling agents, electrolytes, pH regulators, humectants and preservatives (also acting as antiseptics) are frequently employed to modify pharmaceutical properties of the formulation. The addition of gelling polymers, i.e., carbomer, chitosan, hydroxypropyl methyl cellulose (HPMC), methyl cellulose (MC), sodium carboxymethyl cellulose (NaCMC), Pluronic F127, xanthan gum to the aqueous phase increase formulation viscosity enabling for improved stability, emulsion adhesiveness and contact time at the application site [ 76 , 77 , 82 , 84 , 85 , 86 , 89 , 90 , 92 , 93 , 94 , 95 , 98 , 118 , 119 , 120 , 121 , 122 ]. The increased viscosity of the formulation facilitates homogeneous dispersion of the droplets in the continuous phase, limits the mobility of the oil droplets and, as a consequence, prevents flocculation and creaming processes [ 118 , 119 , 120 , 121 , 122 ].…”

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

“…In the next step macroemulsion droplets are disrupted via high shear forces in high-speed homogenization, turbulence in high-pressure homogenization method or bubbles cavitation in ultrasonication method [ 62 , 126 ]. High-pressure homogenization at 75 MPa preceded by high-speed homogenization allowed dos Santos et al to obtain a homogenous nanoemulsion with droplets of 281 nm in a short processing time [ 93 ]. High pressure homogenization method generates a lot of heat and physical stress which may affect the formulation properties and API stability.…”

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

“…This may not be possible for pH sensitive APIs that require higher pH for extended stability or when the benefits of the formulation application exceed the risk of infection as the result of a pH change [ 45 ]. In the revised studies only five micro- and nanoemulsion formulations fall within the physiological range of pH values < 4.5 [ 82 , 84 , 86 , 92 , 93 ]. For other reported formulations the pH values were higher and fell within the slightly acidic range, also considered as physiological [ 78 , 85 , 91 , 94 , 95 , 96 , 97 , 102 ].…”

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

See 4 more Smart Citations

Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels

Smoleński

Karolewicz

Gołkowska

et al. 2021

IJMS

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In order to overcome the limitations associated with vaginal administration of drugs, e.g., the short contact time of the drug form with the mucosa or continuous carrier wash-out, the development of new carriers for gynecological use is necessary. Furthermore, high individual anatomical and physiological variability resulting in unsatisfactory therapeutic efficacy of lipophilic active substances requires application of multicompartment drug delivery systems. This manuscript provides an up-to-date comprehensive review of the literature on emulsion-based vaginal dosage forms (EVDF) including macroemulsions, microemulsions, nanoemulsions, multiple emulsions and self-emulsifying drug delivery systems. The first part of the paper discusses (i) the influence of anatomical-physiological conditions on therapeutic efficacy of drug forms after local and systemic administration, (ii) characterization of EVDF components and the manufacturing techniques of these dosage forms and (iii) methods used to evaluate the physicochemical and pharmaceutical properties of emulsion-based vaginal dosage forms. The second part of the paper presents (iv) the results of biological and in vivo studies as well as (v) clinical evaluation of EVDF safety and therapeutic efficacy across different indications.

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Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

See 3 more Smart Citations

Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels

Smoleński

Karolewicz

Gołkowska

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications

Gosecka

Gosecki

Jaworska‐Krych

2023

Adv Funct Materials

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Hydrogels, as 3D networks containing huge amount of water, display similarity to soft tissues, and thus they are of wide interest in tissue engineering. Hydrogels, due to biocompatibility and porous structure, are valuable therapeutic platforms for hydrophilic drugs. Over the last decade, there has been a strong emphasis on the development of hydrogel platforms with the ability to increase the solubility of hydrophobic drugs. However, the pronounced discrepancy between the hydrophilic character of hydrogels and the hydrophobic nature of numerous pharmacologically active compounds is problematic. In recent years, different strategies are applied using special polymer constructs or composite materials exploiting the advanced scientific knowledge in the area of polymer and lipid‐based nano‐ and microcarriers hydrophobization of the hydrogel turns out to be not only valuable in terms of achieving the ability to dissolve poorly soluble drugs in water, but also proves to be crucial in obtaining bioadhesion in wet conditions, but also, unexpected abnormal water swelling behavior, as well as in mechanical properties such as the dissipation mechanism and self‐healable hydrogel properties. This review is mainly focused on recent advances in the usage of hydrophobized hydrogels in biomedical applications.

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Research progress of hydrogels in the prevention of pelvic inflammatory disease

Xiao,

Ma,

et al. 2024

MedComm – Biomaterials and Applications

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Pelvic inflammatory disease (PID) is a critical global health concern with the potential to lead to adverse outcomes, including infertility and chronic pelvic pain. Since PID is often caused by ascending vaginal infections or urinary tract infections, understanding the treatment of both is critical to preventing PID. Meanwhile, the emergence of drug‐resistant and persistently infected strains poses a growing challenge. This review discusses current clinical treatments for the prevention of PID from the physiologic basis of PID, as well as summarizes the advantages and research progress of hydrogels in the prevention of PID. In contrast to conventional treatments, hydrogels serve as excellent vehicles for vaginal drug delivery, maintaining the presence of the drug at the target site and controlling its release. In the context of urinary tract infections (UTIs), hydrogels are employed primarily as coatings on catheters to prevent and treat catheter‐associated UTIs. Finally, this review summarizes the limitations of hydrogels in PID prevention and future directions for development with the aim of elucidating avenues for clinical treatment of PID and informing further research.

show abstract

A chitosan hydrogel-thickened nanoemulsion containing Pelargonium graveolens essential oil for treatment of vaginal candidiasis

Cited by 35 publications

References 35 publications

Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels

Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels

Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications

Research progress of hydrogels in the prevention of pelvic inflammatory disease

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