A chitosan gold nanoparticles molecularly imprinted polymer based ciprofloxacin sensor

Surya, Sandeep G.; Khatoon, Shahjadi; Lahcen, Abdellatif Ait; Nguyen, Anh‐Dung; Dzantiev, Boris B.; Tarannum, Nazia; Salama, Khaled N.

doi:10.1039/d0ra01838d

Cited by 76 publications

(49 citation statements)

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“…Here we present an explorative study about the effect of different polymerization times—ranging from 15 min to 5 h—on the binding properties of ciprofloxacin-imprinted nanoMIPs. This template was chosen as a system model as imprinted nanoparticles have been extensively reported in the literature as synthetic receptors in sensing devices [ 19 , 20 ] and solid-phase extraction [ 21 ]. Moreover, ciprofloxacin is strongly fluorescent, so it can be detected at very low concentrations by HPLC, making it possible to determine the binding isotherms in conditions of high dilution required by the equilibrium constants typical of nanoMIPs prepared by solid-phase synthesis [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Polymerization Time on the Binding Properties of Ciprofloxacin-Imprinted nanoMIPs Prepared by Solid-Phase Synthesis

et al. 2021

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An innovative approach to imprinted nanoparticles (nanoMIPs) is represented by solid-phase synthesis. Since the polymeric chains grow over time and rearrange themselves around the template, the binding properties of nanoMIPs could depend on the polymerization time. Here we present an explorative study about the effect of different polymerization times on the binding properties of ciprofloxacin-imprinted nanoMIPs. The binding properties towards ciprofloxacin were studied by measuring the binding affinity constants (Keq) and the kinetic rate constants (kd, ka). Furthermore, selectivity and nonspecific binding were valued by measuring the rebinding of levofloxacin onto ciprofloxacin-imprinted nanoMIPs and ciprofloxacin onto diclofenac-imprinted nanoMIPs, respectively. The results show that different polymerization times produce nanoMIPs with different binding properties: short polymerization times (15 min) produced nanoMIPs with high binding affinity but low selectivity (Keq > 107 mol L−1, α ≈ 1); medium polymerization times (30 min–2 h) produced nanoMIPs with high binding affinity and selectivity (Keq ≥ 106 mol L−1, α < 1); and long polymerization times (>2 h) produced nanoMIPs with low binding affinity, fast dissociation kinetics and low selectivity (Keq ≤ 106 mol L−1, kdis > 0.2 min−1, α ≈ 1). The results can be explained as the combined effect of rearrangement and progressive stiffening of the polymer chains around the template molecules.

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Section: Introductionmentioning

confidence: 99%

Effect of Polymerization Time on the Binding Properties of Ciprofloxacin-Imprinted nanoMIPs Prepared by Solid-Phase Synthesis

et al. 2021

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“…Numerous studies have been reported about MIP and nanoparticles to achieve high sensitivity and rapid response to antibiotics. Recently, Surya et al [ 68 ] proposed an electrochemical biomimetic sensor to detect ciprofloxacin (CIP). An AuNPs-chitosan decorated MIP (Ch-AuMIP) was used to modify GCE for the preparation of the sensor.…”

Section: Mip-based Electrochemical Sensorsmentioning

confidence: 99%

Molecularly Imprinted Polymers Combined with Electrochemical Sensors for Food Contaminants Analysis

et al. 2021

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Detection of relevant contaminants using screening approaches is a key issue to ensure food safety and respect for the regulatory limits established. Electrochemical sensors present several advantages such as rapidity; ease of use; possibility of on-site analysis and low cost. The lack of selectivity for electrochemical sensors working in complex samples as food may be overcome by coupling them with molecularly imprinted polymers (MIPs). MIPs are synthetic materials that mimic biological receptors and are produced by the polymerization of functional monomers in presence of a target analyte. This paper critically reviews and discusses the recent progress in MIP-based electrochemical sensors for food safety. A brief introduction on MIPs and electrochemical sensors is given; followed by a discussion of the recent achievements for various MIPs-based electrochemical sensors for food contaminants analysis. Both electropolymerization and chemical synthesis of MIP-based electrochemical sensing are discussed as well as the relevant applications of MIPs used in sample preparation and then coupled to electrochemical analysis. Future perspectives and challenges have been eventually given.

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“…In another example of core–shell systems, Surya et al developed chitosan gold nanoparticles, acting as core, decorated MIP (shell) which was used to modify the glassy carbon electrode (GCE) for the preparation of an electrochemical biomimetic sensor to detect the ciprofloxacin antibiotic [ 51 ]. The simultaneous presence of Au nanoparticles and CS-MIP allowed to enhance sensitivity and selectivity respectively, for the detection of the antibiotic.…”

Section: Different Biomass Waste In Mip Technologymentioning

confidence: 99%

Green Aspects in Molecularly Imprinted Polymers by Biomass Waste Utilization

et al. 2021

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Molecular Imprinting Polymer (MIP) technology is a technique to design artificial receptors with a predetermined selectivity and specificity for a given analyte, which can be used as ideal materials in various application fields. In the last decades, MIP technology has gained much attention from the scientific world as summarized in several reviews with this topic. Furthermore, green synthesis in chemistry is nowadays one of the essential aspects to be taken into consideration in the development of novel products. In accordance with this feature, the MIP community more recently devoted considerable research and development efforts on eco-friendly processes. Among other materials, biomass waste, which is a big environmental problem because most of it is discarded, can represent a potential sustainable alternative source in green synthesis, which can be addressed to the production of high-value carbon-based materials with different applications. This review aims to focus and explore in detail the recent progress in the use of biomass waste for imprinted polymers preparation. Specifically, different types of biomass waste in MIP preparation will be exploited: chitosan, cellulose, activated carbon, carbon dots, cyclodextrins, and waste extracts, describing the approaches used in the synthesis of MIPs combined with biomass waste derivatives.

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A chitosan gold nanoparticles molecularly imprinted polymer based ciprofloxacin sensor

Abstract: In this work, we present a novel study on the development of an electrochemical biomimetic sensor to detect the ciprofloxacin (CIP) antibiotic.

Cited by 76 publications

References 50 publications

Effect of Polymerization Time on the Binding Properties of Ciprofloxacin-Imprinted nanoMIPs Prepared by Solid-Phase Synthesis

Effect of Polymerization Time on the Binding Properties of Ciprofloxacin-Imprinted nanoMIPs Prepared by Solid-Phase Synthesis

Molecularly Imprinted Polymers Combined with Electrochemical Sensors for Food Contaminants Analysis

Green Aspects in Molecularly Imprinted Polymers by Biomass Waste Utilization

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