A chitosan-coated PCL/nano-hydroxyapatite aerogel integrated with a nanofiber membrane for providing antibacterial activity and guiding bone regeneration

Deng, Xinyuan; Yu, Chenghao; Zhang, Xiaopei; Tang, Xunmeng; Guo, Qingxia; Fu, Manfei; Wang, Yuanfei; Fang, Kuanjun; Wu, Tong

doi:10.1039/d4nr00563e

Nanoscale

2024

DOI: 10.1039/d4nr00563e

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A chitosan-coated PCL/nano-hydroxyapatite aerogel integrated with a nanofiber membrane for providing antibacterial activity and guiding bone regeneration

Xinyuan Deng,

Chenghao Yu,

Xiaopei Zhang

et al.

Abstract: Guided bone regeneration (GBR) membrane can act as a barrier to prevent the invasion and interference from foreign soft tissues, promoting infiltration and proliferation of osteoblasts in the bone defect...

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Multifunctional aerogel: A unique and advanced biomaterial for tissue regeneration and repair

Liu,

Xing,

et al. 2024

Materials & Design

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Multifunctional aerogel: A unique and advanced biomaterial for tissue regeneration and repair

Liu,

Xing,

et al. 2024

Materials & Design

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Injectable hybrid nanofibrous spheres made of PLA and nano-hydroxyapatite for cell delivery and osteogenic induction

Wang,

Zhang,

Liu

et al. 2024

Front. Bioeng. Biotechnol.

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IntroductionNanofibrous spheres, with their injectable format and biomimetic three-dimensional topologies that emulate the complexity of natural extracellular environments, have become increasingly attractive for applications in biomedical and regenerative medicine. Our research contributes to this growing field by detailing the design and fabrication of a novel series of polylactic acid/nano-hydroxyapatite (PLA/nHA) hybrid nanofibrous spheres.MethodsThese advanced structures were created by integrating electrospinning and electrospray techniques, which allowed for precise control over the nanofibrous spheres, especially in size. We have conducted a comprehensive investigation into the nanofibrous spheres’ capacity to deliver stem cells efficiently and maintain their viability post-implantation, as well as their potential to induce osteogenic differentiation.Results and DiscussionThe results show that these nanofibrous spheres are biocompatible and injectable, effectively supporting the attachment, growth, and differentiation of bone marrow-derived mesenchymal stem cells while aiding in their targeted transportation to bone defect areas to execute their regenerative functions. The findings of this study could significantly impact the future development of biocompatible materials for a range of therapeutic applications, including bone tissue engineering and regenerative therapy.

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A chitosan-coated PCL/nano-hydroxyapatite aerogel integrated with a nanofiber membrane for providing antibacterial activity and guiding bone regeneration

Abstract: Guided bone regeneration (GBR) membrane can act as a barrier to prevent the invasion and interference from foreign soft tissues, promoting infiltration and proliferation of osteoblasts in the bone defect...

Cited by 2 publications

References 64 publications

Multifunctional aerogel: A unique and advanced biomaterial for tissue regeneration and repair

Multifunctional aerogel: A unique and advanced biomaterial for tissue regeneration and repair

Injectable hybrid nanofibrous spheres made of PLA and nano-hydroxyapatite for cell delivery and osteogenic induction

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