A Chiral Nanocomplex for Multitarget Therapy to Alleviate Neuropathology and Rescue Alzheimer's Cognitive Deficits

Abstract

Alzheimer's disease (AD) is a severe neurodegenerative condition characterized by inflammation, beta‐amyloid (Aβ) plaques, and neurodegeneration, which currently lack effective treatments. Chiral nanomaterials have emerged as a promising option for treating neurodegenerative disorders due to their high biocompatibility, strong sustained release ability, and specific enantiomer selectivity. The development of a stimulus‐responsive chiral nanomaterial, UiO‐66‐NH2@l‐MoS2 QDs@PA‐Ni (MSP‐U), for the treatment of AD is reported. MSP‐U is found to stimulate neural stem cell (NSCs) differentiation, promote in situ hydrogen (H2) production, and clear Aβ plaques. l‐MoS2 QDs modified with l‐Cysteine (l‐Cys) effectively enhance the differentiation of NSCs into neurons through circularly polarized near‐infrared radiation. Doped‐phytic acid nickel (PA‐Ni) improves the activity of l‐MoS2 QDs in scavenging reactive oxygen species at the lesion site via photocatalytic H2 production. Loading l‐MoS2 QDs with UiO‐66 type metal oxide suppresses electron–hole recombination effect, thereby achieving rapid charge separation and improving transport of photogenerated electrons, leading to significantly improved H2 production efficiency. The photothermal effect of MSP‐U also clears the generated Aβ plaques. In vivo evaluations show that MSP‐U improves spatial cognition and memory, suggesting a promising potential candidate for the treatment of AD using chiral nanomaterials.

Chiral nanomaterials in tissue engineering

“…Similarly, Tan et al demonstrated the potential of using chiral nanomaterials for treating AD. 304 To address neuronal loss in AD, L-molybdenum disulfide quantum dots (L-MoS 2 QDs) were used as the central component together with a carrier material and a surface coating. Under CPL NIR radiation, the L-MoS 2 QDs had a stronger effect at inducing neuronal differentiation of neural stem cells (NSCs) compared to the D configuration.…”

Chiral MoS2@BC fibrous membranes selectively promote peripheral nerve regeneration

“…The therapeutic effects of MoS 2 on tumors and neurodegenerative diseases have been reported [ 50 – 53 ]. However, its application in peripheral nerve regeneration has not been studied.…”

“…Chiral nanomaterials are well-known for their excellent chiroptical and chirality-dependent characteristics [ 32 ]. These properties have facilitated their widespread use in tissue engineering [ 33 – 35 ].…”

Self-Cleaning Transparent Photovoltaic p–n Junction Based on CuAlO2/Tm/Bi2O3/ZnO Nanoarrays

“…However, the intrinsic CuAlO 2 /ZnO p–n junction hardly meets the actual demand because the lower intrinsic mobility-concentration kinetic equilibrium makes achieving a high PCE difficult. Hence, effective modification is necessary, − such as surface microstructure treatment or element doping. Transition-layer modification is a very feasible approach because it can increase carrier transportation with the appropriate Fermi level while increasing its mobility via carrier injection.…”