A chiral covalent organic framework (COF) nanozyme with ultrahigh enzymatic activity

Zhou, Ya; Wei, Yunrong; Ren, Jinsong; Qu, Xiaogang

doi:10.1039/d0mh01535k

Cited by 77 publications

(57 citation statements)

References 58 publications

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“…L-DOPA usually serves as a drug in clinics and neurochemistry, while D-DOPA is toxic. 50 Therefore, it is essential to develop a simple, low-cost, and reliable method for the chiral enantiomer identification of DOPA with high sensitivity and selectivity. During chiral recognition, the incubation time used for DOPA recognition by a homochiral electrode is significantly related to the PEC response.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Engineering Homochiral MOFs in TiO₂ Nanotubes as Enantioselective Photoelectrochemical Electrode for Chiral Recognition

et al. 2021

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Enantioselective sensing of chiral molecules is an important issue for both biomedical research and the pharmaceutical industry. Here, an enantioselective photoelectrochemical (PEC) sensor was constructed by integrating TiO 2 nanotubes (NTs) with metal−organic frameworks (MOFs) for the identification of enantiomers. TiO 2 NTs prepared by electrochemical anodization can not only be used as the PEC platform but also as the metal-ion precursor to react with terephthalic acid (BDC) to form MIL-125(Ti) in situ. A postsynthetic exchange (PSE) method was used for exchanging the ligand of MIL-125 by 2-aminoterephthalic acid (BDC-NH 2 ) for further functionalization. Homochirality was then successfully introduced into achiral MIL-125-NH 2 by postsynthetic modification (PSM) with L-histidine (L-His). The resulting homochiral metal−organic frameworks (MOF)-in-NT architecture exhibits excellent discrimination ability for the chiral recognition of 3,4-dihydroxyphenylalanine (L/D-DOPA) enantiomers. Moreover, by adjusting the charge-carrier separation-induced photocurrent variation mechanism, the as-proposed homochiral PEC electrode exhibits a broad application potential for the discrimination of enantiomers. Because of the construction of binder-free monochiral MOF-in-NT structure directly on a Ti-metal substrate, the valuable feature is that the PEC sensing platform can be used directly, thereby providing a stable, simplified, and low-cost sensing device for the recognition of chiral enantiomers.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Engineering Homochiral MOFs in TiO₂ Nanotubes as Enantioselective Photoelectrochemical Electrode for Chiral Recognition

et al. 2021

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“…The incorporation of iron porphyrin and L-or D-histidines endows chiral COF nanozymes with high activity and selectivity in the peroxidase oxidation of dopa enantiomers (Figure 1F). This artificial peroxidase possesses 21.7 times higher activity than natural HRP (Zhou et al, 2020). "Substrate selectivity is more difficult to rationalize for small molecules, such as H 2 , O 2 , CO 2 , and CH 4 , which possess too narrow a range of physical characteristics to allow either precise positioning or discrimination between reactants.…”

Section: Metallocavitins As Bioinspired Catalystsmentioning

confidence: 99%

Metallocavitins as Promising Industrial Catalysts: Recent Advances

Shteinman

2022

Front. Chem.

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The energy, material, and environmental problems of society require clean materials and impose an urgent need to develop effective chemical processes for obtaining and converting energy to ensure further sustainable development. To solve these challenges, it is necessary, first of all, to learn solar energy harvesting through the development of artificial photosynthesis. In our planet, water, carbon dioxide, and methane are such affordable and inexhaustible clean materials. Electro/photocatalytic water splitting, and also CO2 and CH4 transforming into valuable products, requires the search for relevant efficient and selective processes and catalysts. Of great interest is the emerging new generation of bioinspired catalysts—metallocavitins (MCs). MCs are attracting increasing attention of researchers as advanced models of metalloenzymes, whose efficiency and selectivity are well known. The primary field of MC application is fine organic synthesis and enantioselective catalysis. On the other hand, MCs demonstrate high activity for energy challenging reactions involving small gas molecules and high selectivity for converting them into valuable products. This mini-review will highlight some recent advances in the synthesis of organic substances using MCs, but its main focus will be on the rapid development of advanced catalysts for the activation of small molecules, such as H2O, CO2, and CH4, and the prospects for creating related technological processes in the future.

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“…Recently, a variety of new nanomaterials have been found to mimic the activity of enzymes, such as metal–organic frameworks (MOFs), covalent organic frameworks COFs, and Prussian blue (PB) ( Zhou et al, 2020 ). Because of its porosity and large specific surface area and the diversity of structures and functions, MOFs have been widely concerned and applied in a number of crucial sensing, energy, and catalysts domains, including toxins detection, gas storage and separation, and electrocatalysis ( Lustig et al, 2017 ; Li et al, 2018 ).…”

Section: Classificationmentioning

confidence: 99%

“…Because of its porosity and large specific surface area and the diversity of structures and functions, MOFs have been widely concerned and applied in a number of crucial sensing, energy, and catalysts domains, including toxins detection, gas storage and separation, and electrocatalysis ( Lustig et al, 2017 ; Li et al, 2018 ). For example, Zhou et al report the first chiral nanozyme based on mimicking a natural enzyme and the superior structure of COFs, which showed higher activity than the natural enzyme ( Zhou et al, 2020 ). Li et al developed a new kind of microelectrode for in vivo monitoring of H 2 O 2 by electrodeposition of PB onto CNTs assembled carbon fiber microelectrodes ( Li et al, 2016 ).…”

Section: Classificationmentioning

confidence: 99%

Nanozyme Applications: A Glimpse of Insight in Food Safety

Zhou

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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Nanozymes own striking merits, including high enzyme-mimicking activity, good stability, and low cost. Due to the powerful and distinguished functions, nanozymes exhibit widespread applications in the field of biosensing and immunoassay, attracting researchers in various fields to design and engineer nanozymes. Recently, nanozymes have been innovatively used to bridge nanotechnology with analytical techniques to achieve the high sensitivity, specificity, and reproducibility. However, the applications of nanozymes in food applications are seldom reviewed. In this review, we summarize several typical nanozymes and provide a comprehensive description of the history, principles, designs, and applications of nanozyme-based analytical techniques in food contaminants detection. Based on engineering and modification of nanozymes, the food contaminants are classified and then discussed in detail via discriminating the roles of nanozymes in various analytical methods, including fluorescence, colorimetric and electrochemical assay, surface-enhanced Raman scattering, magnetic relaxing sensing, and electrochemiluminescence. Further, representative examples of nanozymes-based methods are highlighted for contaminants analysis and inhibition. Finally, the current challenges and prospects of nanozymes are discussed.

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A chiral covalent organic framework (COF) nanozyme with ultrahigh enzymatic activity

Abstract: Herein, we report the first chiral nanozyme with higher activity than natural enzyme, which is designed based on mimicking of natural enzyme and the superior structure of covalent organic frameworks...

Cited by 77 publications

References 58 publications

Engineering Homochiral MOFs in TiO₂ Nanotubes as Enantioselective Photoelectrochemical Electrode for Chiral Recognition

Engineering Homochiral MOFs in TiO₂ Nanotubes as Enantioselective Photoelectrochemical Electrode for Chiral Recognition

Metallocavitins as Promising Industrial Catalysts: Recent Advances

Nanozyme Applications: A Glimpse of Insight in Food Safety

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A chiral covalent organic framework (COF) nanozyme with ultrahigh enzymatic activity

Abstract: Herein, we report the first chiral nanozyme with higher activity than natural enzyme, which is designed based on mimicking of natural enzyme and the superior structure of covalent organic frameworks...

Cited by 77 publications

References 58 publications

Engineering Homochiral MOFs in TiO2 Nanotubes as Enantioselective Photoelectrochemical Electrode for Chiral Recognition

Engineering Homochiral MOFs in TiO2 Nanotubes as Enantioselective Photoelectrochemical Electrode for Chiral Recognition

Metallocavitins as Promising Industrial Catalysts: Recent Advances

Nanozyme Applications: A Glimpse of Insight in Food Safety

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Product

Resources

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Engineering Homochiral MOFs in TiO₂ Nanotubes as Enantioselective Photoelectrochemical Electrode for Chiral Recognition

Engineering Homochiral MOFs in TiO₂ Nanotubes as Enantioselective Photoelectrochemical Electrode for Chiral Recognition