A Chinese herbal medicine preparation (Pei Tu Qing Xin) for children with moderate-to-severe atopic eczema: a pilot randomized controlled trial

Gu, Sherman; Mo, Xiumei; Zhang, Anthony Lin; Liu, J.; Coyle, Meaghan; Ye, S.; Zhang, Wen; Cranswick, Noel; Xue, Charlie Changli; Chen, Dacan

doi:10.1111/bjd.16988

Cited by 9 publications

(31 citation statements)

References 6 publications

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“…In 2015, we reported the results of an assessor-blind, multicentre RCT of PTQX for the treatment of AD [9, 29]. Still, the molecular mechanism underlying the effects of PTQX against AD urgently requires attention.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Chinese Herbal Formula (PTQX) on NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions

Yan

Zhang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Atopic dermatitis (AD), also known as atopic eczema, is a chronic pruritic inflammatory skin disease. The available systemic therapies for atopic dermatitis are inadequate. Objective. This study aimed to evaluate the effects of the Chinese herbal formula Pei Tu Qing Xin (PTQX) on dermatitis severity and ear swelling, immunomodulation, and the infiltration of mast cells in a mouse model of 1-chloro-2,4-dinitrobenzene- (DNCB-) induced AD. Methods. AD-like symptoms were induced by DNCB in NC/Nga mice. Skin lesions, dermatitis, ear swelling, and scratching behaviour were evaluated. Changes in the T-helper type 1 (Th1), Th2, Th17, and regulatory T (Treg) subtypes and immunoregulation in the spleen and lymph nodes were detected by flow cytometry. Results. Histopathological and immunohistochemical analyses demonstrated that PTQX decreased the DNCB-mediated induction of mast cells and infiltration of inflammatory cells in the ear and dorsal skin. PTQX also reduced the DNCB-induced increase in the serum immunoglobulin E level, pruritus, and dermatitis (red, flaky areas) on the dorsal skin. Furthermore, PTQX regulated the balance between the populations of Th1, Th2, Th17, and Treg cells (particularly the latter two) in the lymph nodes. Conclusions. Our results suggest that the Chinese herbal formula PTQX can alleviate symptoms of AD, such as epithelial damage, redness, swelling, and pruritus, and potentially be used to treat this condition.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Chinese Herbal Formula (PTQX) on NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions

Yan

Zhang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Furthermore, sensitivity analysis was conducted to examine the effects of including only study of low risk of bias; and that of using the change of score from the baseline rather than post-intervention scores on the pooled results. The only study of low risk of bias (Gu 2018) [14] reported no signi cant difference was found between the ICWM and WM alone groups in terms of EASI change. When the change of score from baseline was used, with the missing SD of EASI imputed from gures report in Gu 2018 and that of SCORAD imputed from Chen 2016, ICWM was still superior to WM alone ( SCORAD: MD =-8.15, 95% CI -12.89 to -3.41; EASI: MD =-2.59, 95% CI -4.48 to -0.70).…”

Section: Primary Outcomementioning

confidence: 96%

“…About a third of included studies described their ways of generating a random sequence and thus had low risk of bias in this domain. Only 3 studies described the allocation concealment method [14,17,19]. Five studies took measures to blind participants, study personnel and outcome assessors [14,16,17,19,21].…”

Section: Risk Of Bias Within Studiesmentioning

confidence: 99%

“…Only 3 studies described the allocation concealment method [14,17,19]. Five studies took measures to blind participants, study personnel and outcome assessors [14,16,17,19,21].…”

Section: Risk Of Bias Within Studiesmentioning

confidence: 99%

“…Most studies (53 out of 55) had unclear risk of bias in selective reporting because no relevant information was available. Overall, 2 studies [14,17] were judged to be at low risk of bias, 3 studies [16,21,26] at unclear risk of bias, and the other 50 studies at high risk of bias. (Fig.…”

Section: Risk Of Bias Within Studiesmentioning

confidence: 99%

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Integrated Western and Chinese Medicine Interventions for Atopic Dermatitis: A Systematic Review and Meta-analysis

Sum

Ching

Zhang

et al. 2021

Preprint

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BackgroundAtopic Dermatitis (AD) is a chronic relapsing skin disease characterized by recurring episodes of itchiness with skin erythema and surface damages. Chinese medicine (CM) is widely used for the management of AD in China not only by its own, but also used in combination with conventional therapy (integrated Western-Chinese medicine, ICWM) in China. Although many clinical trials on the effectiveness of ICWM on AD have been reported; however, up to date, no sound evidence has been established on the clinical effectiveness and safety of ICWM for AD. ObjectivesTo systematically review the currently available clinical evidence on the clinical effectiveness and safety of ICWM for AD. MethodsRandomized and quasi-randomized controlled trials, which investigated ICWM interventions with at least one control group using the same conventional interventions, no treatment or placebo treatment, were included. Four English (CENTRAL, MEDLINE, EMBASE, AMED) and three Chinese (CNKI, CBM, WanFang Med) databases were searched. Risk of bias was assessed according to the Cochrane’s tool. Meta-analysis were performed to pool the data. ResultsFrom 1473 database entries, 55 studies were included, of which 5953 participants aged between 35 days to 67 years old were involved. Duration of treatment ranged from 1 to 24 weeks. Only 2 studies were judged to be at low risk of bias, 3 studies at unclear risk of bias, and the other 50 studies at high risk of bias. The research findings suggested that ICWM was superior over WM alone in improving clinical severity of AD (measured by EASI, SCORAD), health-related quality of life (measured by CDLQI, DLQI), long term control of AD (recurrence rate), patients/ investigator global score (effectiveness rate), and serum IgE level. No more adverse events associated with ICWM was found when compared with WM alone. ConclusionAdopting ICWM may be superior to using WM alone in managing AD without risk of more adverse events. However, the current available evidence is still too weak to generate conclusive results.

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Polygonum perfoliatum L. ethanol extract ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin inflammation

Fan,

Xie,

Zhang

et al. 2024

Journal of Ethnopharmacology

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A Chinese herbal medicine preparation (Pei Tu Qing Xin) for children with moderate-to-severe atopic eczema: a pilot randomized controlled trial

Cited by 9 publications

References 6 publications

Therapeutic Effects of Chinese Herbal Formula (PTQX) on NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions

Therapeutic Effects of Chinese Herbal Formula (PTQX) on NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions

Integrated Western and Chinese Medicine Interventions for Atopic Dermatitis: A Systematic Review and Meta-analysis

Polygonum perfoliatum L. ethanol extract ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin inflammation

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