A Chinese Boy With Lupus Anticoagulant-hypoprothrombinemia Syndrome: A Case Report and Review of the Literature

Abstract

We herein report an unusual case of lupus with bleeding diathesis in a Chinese adolescent boy. In the presence of lupus anticoagulant and hypoprothrombinemia, the diagnosis of lupus anticoagulant-hypoprothrombinemia syndrome was made. He responded promptly to immunosuppressive agents and achieved disease remission.

Lupus anticoagulant-hypoprothrombinemia syndrome with severe bleeding diathesis after coronavirus disease 2019: a case report

“…These antibodies are sometimes found after other viral infections, and are usually transient, without thrombotic/bleeding complications ( 8 ). LAHPS is a rare entity reported in association with only a few conditions, such as primary APS, systemic lupus erythematosus, viral infections, and occasionally drug administration and lymphoma ( 9 , 10 ). Patients with LAHPS can have severe bleeding complications, but may also have thrombotic events ( 9 , 10 ).…”

Delayed hemorrhage following deep brain stimulation device placement in a patient with Parkinson’s disease and lupus anticoagulant syndrome: illustrative case

“…We suspect that the hemorrhage occurred secondary to venous infarct, because LA is associated with a paradoxically increased risk of thrombosis. 10 It may be posited that the venous infarct occurred relatively quickly following stage I surgery and that the delayed hemorrhagic conversion was related to hemodynamic changes during insertion of the implantable pulse generator.…”

“…We suspect that the hemorrhage occurred secondary to venous infarct, because LA is associated with a paradoxically increased risk of thrombosis. 10 It may be posited that the venous infarct occurred relatively quickly following stage I surgery and that the delayed hemorrhagic conversion was related to hemodynamic changes during insertion of the implantable pulse generator. Because the patient underwent intraoperative MRI showing successful lead placement, he did not undergo postoperative imaging (e.g., CT on postoperative day 1) following stage I surgery.…”

“…Paradoxically, LA disorders increase the risk of thrombosis, as opposed to bleeding disorders that are normally associated with prolonged PTT. [10][11][12] Here, we describe a case of delayed hemorrhage in a patient following bilateral magnetic resonance imaging (MRI)-guided DBS lead placement for PD, and the patient was found to have LA preoperatively.…”

“…This error in immune response induces prolongation of the partial thromboplastin time (PTT). 10 These disorders are associated with a wide array of pathologies and accompanying diseases. Paradoxically, LA disorders increase the risk of thrombosis, as opposed to bleeding disorders that are normally associated with prolonged PTT.…”