“…To identify immunodominant epitopes, we analyzed five different therapeutic proteins for which evidence of immunogenicity exists in humans, namely, hGH, calcitonin, insulin, IFN-, and Epo (5,6,24,42,43). Although insulin and calcitonin did not contain any clear degenerate binding regions, four, six, and four degenerate binding regions were identified within the hGH, IFN-, and Epo proteins, respectively.…”