Retinoblastoma is the most common malignant tumour of the eye in children and accounts for 3% of all childhood cancers in the UK. It is a life-threatening disease, but over the past four decades, the management of retinoblastoma has evolved tremendously, transforming it from a deadly childhood cancer to a largely curable disease. A swift referral pathway is vital to reduce the risk of mortality. The fist section of this article looks at the epidemiology, signs and symptoms and treatment of retinoblastoma. The second gives an overview of the support work carried out with individuals and families affected by retinoblastoma by UK charity the Childhood Eye Cancer Trust. The final section tells the story of Rob Hopson, a retinoblastoma survivor whose two sons also have the condition.