A chemiluminescence aptasensor for sensitive detection of alpha-fetoprotein based on hemin@ZIF-67

Wang, Jingdao; Hou, Yanan; Sun, Yuanling; Fang, Fang; Luo, Chuannan

doi:10.1007/s00216-022-04099-z

Cited by 12 publications

(7 citation statements)

References 44 publications

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“…The powder X-ray diffraction (PXRD) patterns are employed to confirm the crystalline architecture of ZIF-67 (Figure S1B). PXRD spectra exhibit diffraction peaks at 7.4, 10.4, 12.8, and 18.0°c orresponding to (011), (002), (112), and (222) planes, 34 and the PXRD pattern of ZIF-67 is identical to that of simulated ZIF-67, suggesting the successful synthesis of ZIF-67 with good crystallinity. In addition, X-ray photoelectron spectroscopy (XPS) proves the presence of cobalt in ZIF-67 (Figure S1C,D).…”

Section: •−mentioning

confidence: 86%

Exogenous Co-Reactant-Free Electrochemiluminescent Biosensor for Ratiometric Measurement of α-Glucosidase Based on a ZIF-67-Regulated Hydrogen-Bonded Organic Framework

Cui,

Yang,

Jiang

et al. 2024

ACS Sens.

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The development of highly sensitive and selective analytical approaches for monitoring enzymatic activity is critical for disease diagnosis and biomedical research. Herein, we develop an exogenous co-reactant-free electrochemiluminescence (ECL) biosensor for the ratiometric measurement of α-glucosidase (α-Glu) based on a zeolitic imidazolate framework (ZIF-67)regulated pyrene-based hydrogen-bonded organic framework (HOF-101). Target α-Glu can hydrolyze maltose to α-D-glucose, which can subsequently react with GO x to produce gluconic acid. The resultant gluconic acid can dissolve ZIF-67, leading to the recovery of the HOF-101 cathodic ECL signal and the decrease of the luminol anodic ECL signal. The long-range ordered structure of HOF-101 can speed up charge transfer, resulting in a stable and strong cathodic ECL signal. Moreover, ZIF-67 can not only efficiently quench the ECL signal of HOF-101 due to ECL resonance energy transfer between HOF-101 and ZIF-67 as well as the steric hindrance effect of ZIF-67 but also enhance the anodic ECL emission of luminol in dissolved O 2 system because of its ordered and porous crystalline structure and the atomically dispersed Co 2+ . Notably, HOF-101 possesses a higher ECL efficiency (32.22%) compared with the Ru(bpy) 3 2+ standard. Importantly, this ratiometric ECL biosensor shows high sensitivity (a detection limit of 0.19 U L −1 ) and a broad linear range (0.2−50 U L −1 ). This biosensor can efficiently eliminate systematic errors and enhance detection reliability without the involvement of exogenous co-reactants, and it displays good assay performance in human serum samples, holding great promise in biomedical research studies.

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Section: •−mentioning

confidence: 86%

Exogenous Co-Reactant-Free Electrochemiluminescent Biosensor for Ratiometric Measurement of α-Glucosidase Based on a ZIF-67-Regulated Hydrogen-Bonded Organic Framework

Cui,

Yang,

Jiang

et al. 2024

ACS Sens.

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“…The detection limit of the method for VEGF is 50 pM, and the concentration ranges from 0 to 25 nM ( Li W. et al, 2015 ). Wang J. et al (2022) detected AFP based on the CL system of hemin@ZIF-67–H 2 O 2 -NaOH, achieving a detection limit of 0.13 ng/mL. In a study conducted by Han R. et al (2020) , a sensing platform based on the luminol–H 2 O 2 –metal organic framework (MOF) system was constructed for AFP detection.…”

Section: Optical Aptasensorsmentioning

confidence: 99%

Recent advances in optical aptasensors for biomarkers in early diagnosis and prognosis monitoring of hepatocellular carcinoma

Dong

Wang

Yuan

et al. 2023

Front. Cell Dev. Biol.

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Hepatocellular carcinoma (HCC) accounts for approximately 90% of all primary liver cancers and is one of the main malignant tumor types globally. It is essential to develop rapid, ultrasensitive, and accurate strategies for the diagnosis and surveillance of HCC. In recent years, aptasensors have attracted particular attention owing to their high sensitivity, excellent selectivity, and low production costs. Optical analysis, as a potential analytical tool, offers the advantages of a wide range of targets, rapid response, and simple instrumentation. In this review, recent progress in several types of optical aptasensors for biomarkers in early diagnosis and prognosis monitoring of HCC is summarized. Furthermore, we evaluate the strengths and limitations of these sensors and discuss the challenges and future perspectives for their use in HCC diagnosis and surveillance.

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“…Under the optimal conditions, the CL signal had a linear relationship with the concentration of AFP, in the range of 0.1 ng/L to 30 μg/L; the LOD was 77 pg/L. Wang et al [ 70 ] used hemin@ZIF-67 composites to construct a chemiluminescence (CL) aptasensor for AFP detection. A hemin/ZIF-67 composite was prepared via covalent bonding between the carboxyl groups of hemins and cobalt ion of ZIF-67.…”

Section: Afp Detection Based On Optical Aptamer Biosensormentioning

confidence: 99%

Detection of Alpha-Fetoprotein Using Aptamer-Based Sensors

et al. 2022

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Alpha-fetoprotein (AFP) is widely-known as the most commonly used protein biomarker for liver cancer diagnosis at the early stage. Therefore, developing the highly sensitive and reliable method of AFP detection is of essential demand for practical applications. Herein, two types of aptamer-based AFP detection methods, i.e., optical and electrochemical biosensors, are reviewed in detail. The optical biosensors include Raman spectroscopy, dual-polarization interferometry, resonance light-scattering, fluorescence, and chemiluminescence. The electrochemical biosensors include cyclic voltammetry, electrochemical impedance spectroscopy, and giant magnetic impedance. Looking into the future, methods for AFP detection that are high sensitivity, long-term stability, low cost, and operation convenience will continue to be developed.

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A chemiluminescence aptasensor for sensitive detection of alpha-fetoprotein based on hemin@ZIF-67

Cited by 12 publications

References 44 publications

Exogenous Co-Reactant-Free Electrochemiluminescent Biosensor for Ratiometric Measurement of α-Glucosidase Based on a ZIF-67-Regulated Hydrogen-Bonded Organic Framework

Exogenous Co-Reactant-Free Electrochemiluminescent Biosensor for Ratiometric Measurement of α-Glucosidase Based on a ZIF-67-Regulated Hydrogen-Bonded Organic Framework

Recent advances in optical aptasensors for biomarkers in early diagnosis and prognosis monitoring of hepatocellular carcinoma

Detection of Alpha-Fetoprotein Using Aptamer-Based Sensors

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