A chemically fueled supramolecular glue for self-healing gels

Fores, Jennifer Rodon; Würbser, Michaela A.; Kretschmer, Martin; Rieß, Benedikt; Bergmann, Alexander M.; Lieleg, Oliver; Boekhoven, Job

doi:10.1039/d2sc03691f

Cited by 18 publications

(17 citation statements)

References 49 publications

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“…At least over this second cycle, the performance of the system did not significantly degrade. While the buildup of the urea byproduct must eventually degrade the properties of the system, 23 previous transient gels based on crosslinked polymers were resistant to the urea over many cycles. 14,15 The previously established behavior of Am/AA copolymers and the timescales of the experiments are consistent with the formation of temporary anhydride crosslinks (Scheme 1b).…”

Section: ■ Results and Discussionmentioning

confidence: 98%

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Chemically Fueled Reinforcement of Polymer Hydrogels

et al. 2023

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Carbodiimide-fueled anhydride bond formation has been used to enhance the mechanical properties of permanently crosslinked polymer networks, giving materials that exhibit transitions from soft gels to covalently reinforced gels, eventually returning to the original soft gels. Temporary changes in mechanical properties result from a transient network of anhydride crosslinks, which eventually dissipate by hydrolysis. Over an order of magnitude increase in the storage modulus is possible through carbodiimide fueling. The time-dependent mechanical properties can be modulated by the concentration of carbodiimide, temperature, and primary chain architecture. Because the materials remain rheological solids, new material functions such as temporally controlled adhesion and rewritable spatial patterns of mechanical properties have been realized.

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Section: ■ Results and Discussionmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Chemically Fueled Reinforcement of Polymer Hydrogels

et al. 2023

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“…The hydrogels formation which possessed a rheological structure was immediately briefly evaluated by the test vial inversion method [ 56 , 57 , 58 ] by macroscopic analysis of the properties of not flowing and not deforming under its own weight ( Figure 1 f,g). The two developed hydrogels were viscous, homogeneous and presented no deformation or flow when the vial was inverted.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Aloe vera Based Biocompatible Hydrogel for Use in Dermatological Applications

Chelu

Musuc

Aricov

et al. 2023

IJMS

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The present research aims to describe a new methodology to obtain biocompatible hydrogels based on Aloe vera used for wound healing applications. The properties of two hydrogels (differing in Aloe vera concentration, AV5 and AV10) prepared by an all-green synthesis method from raw, natural, renewable and bioavailable materials such as salicylic acid, allantoin and xanthan gum were investigated. The morphology of the Aloe vera based hydrogel biomaterials was studied by SEM analysis. The rheological properties of the hydrogels, as well as their cell viability, biocompatibility and cytotoxicity, were determined. The antibacterial activity of Aloe vera based hydrogels was evaluated both on Gram-positive, Staphylococcus aureus and on Gram-negative, Pseudomonas aeruginosa strains. The obtained novel green Aloe vera based hydrogels showed good antibacterial properties. In vitro scratch assay demonstrated the capacity of both AV5 and AV10 hydrogels to accelerate cell proliferation and migration and induce closure of a wounded area. A corroboration of all morphological, rheological, cytocompatibility and cell viability results indicates that this Aloe vera based hydrogel may be suitable for wound healing applications.

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] One of the widely adopted strategies to construct out-of-equilibrium assembly systems is to couple the self-assembly process with chemical reactions. 3,4,[16][17][18][19][20][21] The precursors are converted into building blocks by chemical-fueled activation reactions, followed by the self-assembly of activated building blocks. Simultaneously, the building blocks are continuously deactivated and reverted into the original precursors, resulting in transient assembly systems.…”

Section: Introductionmentioning

confidence: 99%