We consider operators T from C 1 (R) to C(R) satisfying the "chain rule"and study under which conditions this functional equation admits only the derivative or its powers as solutions. We also consider T operating on other domains like C k (R) for k ∈ N 0 or k = ∞ and study the more general equation T (f • g) = (Tf ) • g · Ag, f, g ∈ C 1 (R) where both T and A map C 1 (R) to C(R).