A Chalone Like Faktor of Eac Cells

Lehmann, WD; Graetz, H; Samtleben, Rainer; Langen, P.

doi:10.1042/bst009215pa

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2011

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“…Our observation of curcumin-sensitizing doxorubicin-resistant ascites carcinoma cells, whose origin is mammary epithelial carcinoma (51), emphasizes that curcumin in combination with doxorubicin can be used as an effective treatment strategy to reverse breast cancer drug resistance. Consistently, curcumin has been reported to increase the efficacy of doxorubicin by modulating the function of the multidrug resistancelinked ATP-binding cassette transporter ABCG2 (52) and to sensitize glioma cells in a p53-and caspase-independent manner by inhibition of AP-1 and NFB signaling pathways (53).…”

Section: Discussionmentioning

confidence: 99%

Curcumin Enhances the Efficacy of Chemotherapy by Tailoring p65NFκB-p300 Cross-talk in Favor of p53-p300 in Breast Cancer

Sen

Mohanty

Hossain

et al. 2011

Journal of Biological Chemistry

100

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Background: Constitutive activation of NFB has been found in various cancers, causing resistance to chemotherapeutic drugs. Results: Curcumin pretreatment alleviates p65NFB activation and hence tailors p65NFB-p300 cross-talk in favor of p53-p300 in drug-resistant cells. Conclusion:This preclinical study suggests curcumin as a potent chemo-sensitizer to improve the therapeutic index. Significance: These results suggest that curcumin can be developed into an adjuvant chemotherapeutic drug.

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Section: Discussionmentioning

confidence: 99%