A challenging epigenetic message: telomerase activity is associated with complex changes in lifestyle

Falus, András; Marton, I; Borbényi, Erika; Tahy, Ádám; Karádi, Pál; Aradi, J.; Stauder, Adrienne; Kopp, Mária

doi:10.1042/cbi20110046

Cited by 7 publications

(7 citation statements)

References 22 publications

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“…Given the protective effects of telomerase activity (42), future epidemiological studies examining the effects of MBB on telomerase activity is warranted. Because of the combined effects of multiple health-enhancing behaviors on health (28,41), as well as LTL (16,17,36), future epidemiological work examining the additive and additive interaction effects of multiple health behaviors on LTL is warranted. Lastly, given that it is not entirely certain whether LTL is a cause or consequence of morbidity (e.g., cardiovascular disease), future longitudinal mediational models examining whether LTL mediates the relation between MBB and morbidity/mortality is warranted.…”

Section: Discussionmentioning

confidence: 99%

Movement-Based Behaviors and Leukocyte Telomere Length among US Adults

Loprinzi

Loenneke

Blackburn

2015

Medicine &Amp; Science in Sports &Amp; Exercise

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Section: Discussionmentioning

confidence: 99%

Movement-Based Behaviors and Leukocyte Telomere Length among US Adults

Loprinzi

Loenneke

Blackburn

2015

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Noteworthy, lifestyle changes influence epigenetic regulation of TR [ 416 ]. For instance, chronic psychological stress is believed to contribute to telomere shortening in humans at different life stages [ 417 , 418 ] in an apparent dose-dependent way [ 419 ], and diverse dietary compounds can have an impact on TERT by modulating the activity of DNA methyltransferases (DNMTs) and histone-modifying enzymes [ 420 , 421 ].…”

Section: Telomere Maintenance Mechanismsmentioning

confidence: 99%

Telomere Maintenance Mechanisms in Cancer

Gaspar

Sá

Lopes

et al. 2018

Genes

135

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Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere shortening, an inevitable process due to successive cell divisions. In most tumour cells, telomere length (TL) is maintained by reactivation of telomerase, while a small part acquires immortality through the telomerase-independent alternative lengthening of telomeres (ALT) mechanism. In the last years, a great amount of data was generated, and different TMMs were reported and explained in detail, benefiting from genome-scale studies of major importance. In this review, we address seven different TMMs in tumour cells: mutations of the TERT promoter (TERTp), amplification of the genes TERT and TERC, polymorphic variants of the TERT gene and of its promoter, rearrangements of the TERT gene, epigenetic changes, ALT, and non-defined TMM (NDTMM). We gathered information from over fifty thousand patients reported in 288 papers in the last years. This wide data collection enabled us to portray, by organ/system and histotypes, the prevalence of TERTp mutations, TERT and TERC amplifications, and ALT in human tumours. Based on this information, we discuss the putative future clinical impact of the aforementioned mechanisms on the malignant transformation process in different setups, and provide insights for screening, prognosis, and patient management stratification.

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“…It is well documented that TA is regulated in addition to genetic by epigenetic mechanisms (reviewed in [3,34,105,106,107]) and epigenetic regulation of TA is associated with complex changes in lifestyle [108]. TA is controlled by multiple mechanisms [3], e.g., down regulation of DNMTs reduces the hypermethylated state of the hTERT promoter by allowing repressor binding, chromatin remodeling changes the state of histones at the hTERT promoter by influencing the binding of transcription factors, miRNAs can change in posttranscriptional way hTERT transcript directly or indirectly via affecting regulatory transcription factors, and dietary compounds can influence hTERT by modulation the activity of DNMTs and histone-modifying enzymes.…”

Section: Epigenetic Regulation Of Tmmsmentioning

confidence: 99%

Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas

Naderlinger

Holzmann

2017

Genes

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High-grade astrocytoma of WHO grade 4 termed glioblastoma multiforme (GBM) is a common human brain tumor with poor patient outcome. Astrocytoma demonstrates two known telomere maintenance mechanisms (TMMs) based on telomerase activity (TA) and on alternative lengthening of telomeres (ALT). ALT is associated with lower tumor grades and better outcome. In contrast to ALT, regulation of TA in tumors by direct mutation and epigenetic activation of the hTERT promoter is well established. Here, we summarize the genetic background of TMMs in non-malignant cells and in cancer, in addition to clinical and pathological features of gliomas. Furthermore, we present new evidence for epigenetic mechanisms (EMs) involved in regulation of ALT and TA with special emphasis on human diffuse gliomas as potential therapeutic drug targets. We discuss the role of TMM associated telomeric chromatin factors such as DNA and histone modifying enzymes and non-coding RNAs including microRNAs and long telomeric TERRA transcripts.

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A challenging epigenetic message: telomerase activity is associated with complex changes in lifestyle

Cited by 7 publications

References 22 publications

Movement-Based Behaviors and Leukocyte Telomere Length among US Adults

Movement-Based Behaviors and Leukocyte Telomere Length among US Adults

Telomere Maintenance Mechanisms in Cancer

Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas

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