A certain protective effect of vitamin D against dental caries in <scp>US</scp> children and youth: A cross‐sectional study

Pu, Rui; Fu, Mengdie; Li, Na; Jiang, Zhiwei

doi:10.1111/jphd.12571

Cited by 4 publications

(11 citation statements)

References 48 publications

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“…This level of oral hygiene practice, however, did not translate into detailed reports on dental visits or the consumption of cariogenic foods and drinks. Pu et al [27] did not report on these influencing factors, yet the racial composition of their study population, with 13.6% identifying as Black, adds another layer to the demographic analysis of dental caries risk factors. Overall, patients with dark skin colors represented a proportion ranging from 9.8% in the study by Al-Darwish et al [25] to 33.1% in Akinkube et al study [21].…”

Section: Influencing Factorsmentioning

confidence: 91%

“…Lastly, Pu et al [27] presented evidence of a protective role of Vitamin D, with an OR of 0.80 for caries among individuals with levels ≥ 50 nmol/L, reinforcing the beneficial impact of sufficient Vitamin D levels on dental caries risk. Kim et al [28], with 61.7% of the population being Vitamin D-insufficient, found a significant association between Vitamin D insufficiency and caries risk, with an OR of 1.29, as presented in Table 4 and Figure 2.…”

Section: Vitamin D and Dental Assessmentmentioning

confidence: 92%

Section: Study Characteristicsmentioning

confidence: 99%

“…This systematic review analyzed a total of eight studies [21][22][23][24][25][26][27][28], detailed in Table 1. These studies were conducted across a variety of countries, including the United States [21,24], Portugal [22], the United Kingdom [23], Qatar [25], South Korea [26], China [27] and Korea [28], spanning the years 2013 to 2023. All identified studies employed a cross-sectional design, offering a snapshot of the relationship between serum Vitamin D levels and caries in the permanent teeth of children and adolescents at a single point in time.…”

Section: Study Characteristicsmentioning

confidence: 99%

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A Systematic Review of the Relationship between Serum Vitamin D Levels and Caries in the Permanent Teeth of Children and Adolescents

Buzatu,

Luca,

Bumbu

2024

Dentistry Journal

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This systematic review critically evaluates the association between serum Vitamin D levels and dental caries incidence in the permanent teeth of children and adolescents. The search strategy comprised three databases (PubMed, Scopus, Embase), up to November 2023, targeting studies on the correlation between Vitamin D and dental caries in permanent dentition. The eligibility criteria focused on observational studies involving children and adolescents aged 12 to 19 years with permanent dentition. The screening process, guided by the PRISMA guidelines and the Newcastle–Ottawa Scale for quality assessment, resulted in the inclusion of eight studies conducted across various global regions from 2013 to 2023. The analysis revealed that Vitamin D insufficiency and deficiency were prevalent among the study populations, ranging from 17.3% to 69.4%. Specifically, children and adolescents with Vitamin D insufficiency (<50 nmol/L) were found to have significantly higher odds of developing caries, with odds ratios (ORs) ranging from 1.13 to 2.57. Conversely, two studies indicated a protective effect of higher Vitamin D levels, with an OR of 0.80 and 0.59, respectively, for caries among children and adolescents with serum levels ≥ 50 nmol/L, suggesting an inverse relationship between Vitamin D status and caries risk. The results indicate both the protective role of adequate serum levels of Vitamin D above 20 ng/mL and the increased risk associated with insufficient levels below this threshold. However, the variations in study quality, methodologies and geographic settings underscore the challenges in drawing universal conclusions. Despite these limitations, our review suggests that improving Vitamin D status could be a beneficial component of preventive strategies against dental caries in children and adolescents, warranting further research to clarify the clinical significance of our findings.

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Section: Influencing Factorsmentioning

confidence: 91%

Section: Vitamin D and Dental Assessmentmentioning

confidence: 92%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

A Systematic Review of the Relationship between Serum Vitamin D Levels and Caries in the Permanent Teeth of Children and Adolescents

Buzatu,

Luca,

Bumbu

2024

Dentistry Journal

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“…Furthermore, severe vitamin D deficiencies have been shown to contribute to tooth hypo-mineralization and enamel hypoplasia [34,35]. Lower levels of vitamins A and/or D have been associated with higher prevalence of dental caries among adults and/or children in some epidemiological studies [36][37][38][39][40][41][42] but not others [43]. It has been suggested that vitamin D may protect against dental caries by modulating immunity in a manner that promotes eradication of cariogenic bacteria [36].…”

Section: Vitamins a And Dmentioning

confidence: 99%

The Potential Systemic Role of Diet in Dental Caries Development and Arrest: A Narrative Review

Malin,

Wang,

Khan

et al. 2024

Nutrients

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Current conceptualizations of dental caries etiology center primarily on the local role of sugar, starch, or other fermentable carbohydrates on tooth enamel demineralization—a well-established and empirically supported mechanism. However, in addition to this mechanism, studies dating back to the early 1900s point to an important systemic role of diet and nutrition, particularly from pasture-raised animal-source foods (ASF), in dental caries etiology and arrest. Findings from animal and human studies suggest that adherence to a diet high in calcium, phosphorus, fat-soluble vitamins A and D, and antioxidant vitamin C, as well as low in phytates, may contribute to arrest and reversal of dental caries, particularly among children. Furthermore, findings from observational and experimental studies of humans across the life-course suggest that fat-soluble vitamins A, D, and K2 may interact to protect against dental caries progression, even within a diet that regularly contains sugar. While these historic studies have not been revisited in decades, we emphasize the need for them to be reinvestigated and contextualized in the 21st century. Specifically, methodologically rigorous studies are needed to reinvestigate whether historical knowledge of systemic impacts of nutrition on dental health can help to inform current conceptualizations of dental caries etiology, prevention, and arrest.

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Association between Vitamin D Levels and Dental Caries: A Systematic Review and Dose-Response Meta-Analysis of Cross-Sectional Studies

Mahmood,

Tassery,

Tardivo

et al. 2023

Applied Sciences

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Background and Aims: Previous observational studies found inconsistent associations between serum vitamin D levels and dental caries risk. A dose-response meta-analysis of cross-sectional studies was performed to investigate the association. Methods: To April 2023, the ISI Web of Science, PubMed, Scopus, and Google Scholar databases were searched for published papers. Finally, 13 cross-sectional studies were considered that provided odds ratios (ORs) with 95% confidence intervals (CIs) for dental caries in relation to serum vitamin D levels across all age groups. Two reviewers conducted a thorough screening of the studies, data extraction, bias risk assessment, and evidence quality. A random-effect model was used to assess the pooled estimated odd ratios (with 95% confidence intervals). A weighted mixed-effects dose-response meta-analysis in one stage was carried out. Results: Dental caries was significantly more likely to occur when serum vitamin D levels were low compared to high (OR: 1.41; 95% CI: 1.18, 1.68; GRADE = poor confidence). With a 10 nmol/L increase in serum vitamin D level, linear dose-response analysis showed a significant 3% (OR: 0.97; 95% CI: 0.96, 0.99) decrease in the likelihood of dental caries. Serum vitamin D levels and dental caries were found to be inversely correlated, with a significant dose-response relationship at levels greater than 78 nmol/L. Conclusion: This meta-analysis showed that vitamin D insufficiency was strongly associated with dental caries, and that a 10 nmol/L increase in blood 25(OH)D levels was linked to a 3% decrease in dental caries. However, the findings may have less clinical significance due to the uncertainty of the evidence.

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A certain protective effect of vitamin D against dental caries in US children and youth: A cross‐sectional study

Cited by 4 publications

References 48 publications

A Systematic Review of the Relationship between Serum Vitamin D Levels and Caries in the Permanent Teeth of Children and Adolescents

A Systematic Review of the Relationship between Serum Vitamin D Levels and Caries in the Permanent Teeth of Children and Adolescents

The Potential Systemic Role of Diet in Dental Caries Development and Arrest: A Narrative Review

Association between Vitamin D Levels and Dental Caries: A Systematic Review and Dose-Response Meta-Analysis of Cross-Sectional Studies

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