A cerebellar role in performance monitoring – Evidence from EEG and voxel-based morphometry in patients with cerebellar degenerative disease

Peterburs, Jutta; Thürling, Markus; Rustemeier, Martina; Göricke, Sophia; Suchan, Boris; Timmann, Dagmar; Bellebaum, Christian

doi:10.1016/j.neuropsychologia.2015.01.017

Cited by 44 publications

(51 citation statements)

References 58 publications

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“…The comparable task-modulation of networks for the IC and WM tasks might suggest that a partial reorganization of the networks required for execution of these higher-order tasks occurred in patients. Of note, while functional reorganization can explain the result patterns we observed in patients with longstanding lesions, this might not be the case in patients with progressive degenerative cerebellar diseases [53–55]. …”

Section: Discussionmentioning

confidence: 71%

Neuronal correlates of cognitive function in patients with childhood cerebellar tumor lesions

et al. 2017

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While it has been shown that cerebellar tumor lesions have an impact on cognitive functions, the extent to which they shape distant neuronal pathways is still largely undescribed. Thus, the present neuroimaging study was designed to investigate different aspects of cognitive function and their neuronal correlates in patients after childhood cerebellar tumor surgery. An alertness task, a working memory task and an incompatibility task were performed by 11 patients after childhood cerebellar tumor surgery and 17 healthy controls. Neuronal correlates as reflected by alterations in functional networks during tasks were assessed using group independent component analysis. We were able to identify eight networks involved during task performance: default mode network, precuneus, anterior salience network, executive control network, visual network, auditory and sensorimotor network and a cerebellar network. For the most ‘basic’ cognitive tasks, a weaker task-modulation of default mode network, left executive control network and the cerebellar network was observed in patients compared to controls. Results for higher-order tasks are in line with a partial restoration of networks responsible for higher-order task execution. Our results provide tentative evidence that the synchronicity of brain activity in patients was at least partially restored in the course of neuroplastic reorganization, particularly for networks related to higher-order cognitive processes. The complex activation patterns underline the importance of testing several cognitive functions to assess the specificity of cognitive deficits and neuronal reorganization processes after brain lesions.

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Section: Discussionmentioning

confidence: 71%

Neuronal correlates of cognitive function in patients with childhood cerebellar tumor lesions

et al. 2017

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“…Cerebellar activation has been linked to performance monitoring during task engagement. Particularly, it has been linked to post-error processing in relation to motor responses (Peterburs et al, 2015). All of the presently included updating tasks incorporated button-press responses, consistent with involvement of post-error motor response processes.…”

Section: Discussionmentioning

confidence: 99%

Informing the Structure of Executive Function in Children: A Meta-Analysis of Functional Neuroimaging Data

McKenna

Rushe

Woodcock

2017

Front. Hum. Neurosci.

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The structure of executive function (EF) has been the focus of much debate for decades. What is more, the complexity and diversity provided by the developmental period only adds to this contention. The development of executive function plays an integral part in the expression of children's behavioral, cognitive, social, and emotional capabilities. Understanding how these processes are constructed during development allows for effective measurement of EF in this population. This meta-analysis aims to contribute to a better understanding of the structure of executive function in children. A coordinate-based meta-analysis was conducted (using BrainMap GingerALE 2.3), which incorporated studies administering functional magnetic resonance imaging (fMRI) during inhibition, switching, and working memory updating tasks in typical children (aged 6–18 years). The neural activation common across all executive tasks was compared to that shared by tasks pertaining only to inhibition, switching or updating, which are commonly considered to be fundamental executive processes. Results support the existence of partially separable but partially overlapping inhibition, switching, and updating executive processes at a neural level, in children over 6 years. Further, the shared neural activation across all tasks (associated with a proposed “unitary” component of executive function) overlapped to different degrees with the activation associated with each individual executive process. These findings provide evidence to support the suggestion that one of the most influential structural models of executive functioning in adults can also be applied to children of this age. However, the findings also call for careful consideration and measurement of both specific executive processes, and unitary executive function in this population. Furthermore, a need is highlighted for a new systematic developmental model, which captures the integrative nature of executive function in children.

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“…A previous VBM study suggests involvement of the posterolateral cerebellar region in motor and cognitive functions in patients with cerebellar degenerative disease based on correlations between gray matter volume loss in the left Crus II and right lobule VI and increased error rates in performance monitoring (48). Considering the literature is limited in VBM studies that localize function in patients with cerebellar degeneration, specifically SCA6, our study presents a valuable contribution to the current understanding of specific cerebellar regions involved in motor and cognitive performance in this population of patients.…”

Section: Discussionmentioning

confidence: 99%

Distinct cerebellar regions related to motor and cognitive performance in SCA6 patients

et al. 2017

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Objective To demonstrate a correlation between anatomic regional changes in Spinocerebellar Ataxia type 6 (SCA6) patients and measures of cognitive performance on neuropsychological tests. Methods Neurocognitive testing was conducted on 24 SCA6 and 28 control subjects. For each cognitive test, SCA6 patients were compared against the controls using Student’s t-test. For the cerebellar patients, using voxel based morphometry, correlations between cerebellar gray matter volume at each voxel and performance on the neuropsychological exams were calculated using the Pearson correlation coefficient implemented in SPM8. Results Compared to controls, SCA6 patients exhibited significantly impaired performance on the following cognitive tests: Rey-Auditory Verbal Learning Test Trial V, Controlled Oral Word Association phonemic test and semantic-verb test, Rey-Osterrieth Complex Figure copy test as well as immediate and delayed visuo-spatial memory recall test, Trail Making Test (TMT) Part A and Part B, Stroop Color Task completion time, Stroop Color-Word Task score, and Grooved Pegboard Test (GPT) Dominant and Non-Dominant Hand time. Correlations of gray matter density with cognitive test performance were determined for all SCA6 subjects. Using a p-value threshold of 0.001 and family-wise small volume error correction, significant correlations were found for GPT Non-Dominant, GPT Dominant, TMT Part A, and TMT Part B. Conclusion Different regional patterns of cerebellar involvement were found for the motoric GPT task and the executive version of the TMT. The results for the GPT strongly indicated that the integrity of medial superior hemispheric regions was associated with motor task performance, whereas executive cognitive function was localized in distinctly different inferior regions. This is the first VBM study to differentiate cognitive and motor contributions of the cerebellum.

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A cerebellar role in performance monitoring – Evidence from EEG and voxel-based morphometry in patients with cerebellar degenerative disease

Cited by 44 publications

References 58 publications

Neuronal correlates of cognitive function in patients with childhood cerebellar tumor lesions

Neuronal correlates of cognitive function in patients with childhood cerebellar tumor lesions

Informing the Structure of Executive Function in Children: A Meta-Analysis of Functional Neuroimaging Data

Distinct cerebellar regions related to motor and cognitive performance in SCA6 patients

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