A central odontogenic fibroma exhibiting pleomorphic fibroblasts and numerous calcifications

Günhan, Ömer; Gürbüzer, Bahadır; Gardner, David G.; Demiriz, Murat; Finci, R

doi:10.1016/0266-4356(91)90173-3

Cited by 25 publications

(13 citation statements)

References 5 publications

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“…Histologically, central odontogenic fibromas (COFs) are regarded as benign fibroblastic neoplasms characterized by the presence of mature collagen with numerous interposed fibroblasts and variable amounts of apparently inactive odontogenic epithelial nests (1). This type of neoplasm has been described 68 times in the latest reviews in the literature (2), and in only one case was it seen to present pleomorphic fibroblasts (3) with association to an inflammatory cyst – as in our patient (4). Although the lesion has been diagnosed in individuals ranging from 5 to 80 years of age, it is more frequent in the third and fourth decades of life.…”

Section: Commentssupporting

confidence: 52%

Locally aggressive central odontogenic fibroma associated to an inflammatory cyst: a clinical, histological and immunohistochemical study

Cercadillo-Ibarguren¹,

Berini-Aytés²,

Molina

et al. 2006

J Oral Pathology Medicine

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The case describes a 38-year-old woman presenting a multilocular radiolucency affecting the entire right half of the lower jaw, with an unerupted third molar displaced to the region of the coronoid process. The histological study showed the presence of fibroblasts, focally with pleomorphic nuclei, dense collagen and an odontogenic epithelium with dystrophic calcifications. A cyst with an important inflammatory infiltrate was, moreover, observed.

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Section: Commentssupporting

confidence: 52%

Locally aggressive central odontogenic fibroma associated to an inflammatory cyst: a clinical, histological and immunohistochemical study

Cercadillo-Ibarguren¹,

Berini-Aytés²,

Molina

et al. 2006

J Oral Pathology Medicine

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“…An unusual example of simple odontogenic fibroma that exhibited numerous pleomorphic fibroblasts and calcifications has been reported by GC>iHAN et at. (13) (Fig. 6).…”

Section: Odontogenic Fibroma Exhibiting Pieomorphic Fibroblastsmentioning

confidence: 97%

Central odontogenic fibroma current concepts

Gardner

1996

J Oral Pathology Medicine

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The author reviews current knowledge concerning the central odontogenic fibroma, which at present in incompletely understood, and reaches the following conclusions. 1) The separation of this lesion into simple and WHO types remains valid because they exhibit different histologic features. However, more care should be taken in rendering the diagnosis of the WHO type than in the past; unlike the simple type, it is a fibroblastic lesion. 2) Complex central odontogenic fibroma is a more appropriate term than the WHO type because the WHO does not use the latter term in its 1992 manual. 3) The microscopic distinction of simple odontogenic fibroma from desmoplastic fibroma remains difficult in some cases. 4) The granular cell odontogenic tumor, which has sometimes been referred to as a type of odontogenic fibroma, is a separate entity, although some simple odontogenic fibromas exhibit scattered granular cells. 5) The separation of lesions that have been reported recently as odontogenic fibromas with giant cell reactions from central giant cell granulomas that exhibit foci of odontogenic epithelium requires further study.

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“…The coexistence of ossifying fibroma and OdonF is singularly unique and rare [41]. This variant differs from the giant cell lesion/OdonF chimera in that two individual tumor entities do not become juxtaposed, but, rather, are fully integrated.…”

Section: Outcomementioning

confidence: 98%

Odontogenic Fibroma, Including Amyloid and Ossifying Variants

Eversole¹

2011

Head and Neck Pathol

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Sixty-five cases of odontogenic fibroma (OdonF) are herein presented having been segregated into peripheral, extra bony tumors (n = 40) and tumors arising in bone or centrally (n = 25). All cases were characterized microscopically by a fibrous proliferation that varied within and between cases in cellularity and collagen fibril diameter, with intermixed odontogenic epithelial islands and cords. All central lesions presented as well demarcated radiolucencies and resorption of contiguous tooth roots was a common finding. These intraosseous lesions were of the WHO type; the so-called nonWHO type was excluded as all lesions with this diagnosis were devoid of an epithelial component and could be reclassified as other soft tissue fibrogenic tumors. Neither the central tumors nor the peripheral lesions recurred following enucleation/curettage, with a mean follow-up of 4 and 3.4 years respectively. Three distinct microscopic variations were encountered in this series: (1) two cases of OdonF with giant cell reaction, (2) two instances of OdonF with ossifying fibroma; and (3) four instances of OdonF with odontogenic ameloblast-associated protein (ODAM), an amyloid-like protein found deposited adjacent to epithelial cords plus CD1a+/S-100+ Langerhans dendritic cells entwined around the epithelial element. A single instance of the odontogenic fibroma-like hamartoma/enamel hypoplasia syndrome has been included in this series.

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A central odontogenic fibroma exhibiting pleomorphic fibroblasts and numerous calcifications

Cited by 25 publications

References 5 publications

Locally aggressive central odontogenic fibroma associated to an inflammatory cyst: a clinical, histological and immunohistochemical study

Locally aggressive central odontogenic fibroma associated to an inflammatory cyst: a clinical, histological and immunohistochemical study

Central odontogenic fibroma current concepts

Odontogenic Fibroma, Including Amyloid and Ossifying Variants

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