A Cellular Trojan Horse for Delivery of Therapeutic Nanoparticles into Tumors

Choi, Mehee; Stanton-Maxey, Katie J.; Stanley, Jennifer K; Levin, Carly S.; Bardhan, Rizia; Akin, Demir; Badve, Sunil; Sturgis, Jennifer; Robinson, J. Paul; Bashir, Rashid; Halas, Naomi J.; Clare, Susan E.

doi:10.1021/nl072209h

Cited by 537 publications

(487 citation statements)

References 40 publications

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“…Galvanic replacement is an electrochemical redox reaction where the oxidation of one metal, the sacrificial template, is generated by contact in solution with another metal having a higher reduction potential [96][97][98][99]. The template being oxidized, possessing the lower reduction potential and higher rate of diffusion, loses electrons and the metal being reduced gains electrons.…”

Section: Galvanic Replacementmentioning

confidence: 99%

“…This is attributed to competition between the cooling of the lattice and the rate of the nanoparticle absorption of light [169]. In contrast, the application of a CW laser is believed to dissipate absorbed energy into its environment as the temperature of the nanoparticle increases due a relatively stable thermal relationship between the nanoparticles and solvent [99,164,165].…”

Section: The Influence Of Laser Mode and Powermentioning

confidence: 99%

“…Traditionally drugs in photothermal therapies are delivered via polymeric structures or liposomes [99,[227][228][229][230][231][232]. However, these delivery agents are hindered by several factors.…”

Section: Multi-modal Treatmentsmentioning

confidence: 99%

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Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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Section: Galvanic Replacementmentioning

confidence: 99%

Section: The Influence Of Laser Mode and Powermentioning

confidence: 99%

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Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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“…Stem cells with the intrinsic tumor tropism have attracted huge interests as the emerging biovehicles to deliver therapeutic agents for cancer treatment 15, 16, 17, 18, 19, 20. Studies show that chemokines such as stromal cell–derived factor‐1 (SDF‐1) are important factors to facilitate stem cell migration to lesion locations via the specific receptors like CXCR4 21, 22.…”

Section: Introductionmentioning

confidence: 99%

A Light‐Triggered Mesenchymal Stem Cell Delivery System for Photoacoustic Imaging and Chemo‐Photothermal Therapy of Triple Negative Breast Cancer

Feng

Yang

et al. 2018

Advanced Science

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Targeted therapy is highly challenging and urgently needed for patients diagnosed with triple negative breast cancer (TNBC). Here, a synergistic treatment platform with plasmonic–magnetic hybrid nanoparticle (lipids, doxorubicin (DOX), gold nanorods, iron oxide nanocluster (LDGI))–loaded mesenchymal stem cells (MSCs) for photoacoustic imaging, targeted photothermal therapy, and chemotherapy for TNBC is developed. LDGI can be efficiently taken up into the stem cells with good biocompatibility to maintain the cellular functions. In addition, CXCR4 on the MSCs is upregulated by iron oxide nanoparticles in the LDGI. Importantly, the drug release and photothermal therapy can be simultaneously achieved upon light irradiation. The released drug can enter the cell nucleus and promote cell apoptosis. Interestingly, light irradiation can control the secretion of cellular microvehicles carrying LDGI for targeted treatment. A remarkable in vitro anticancer effect is observed in MDA‐MB‐231 with near‐infrared laser irradiation. In vivo studies show that the MSCs‐LDGI has the enhanced migration and penetration abilities in the tumor area via both intratumoral and intravenous injection approaches compared with LDGI. Subsequently, MSCs‐LDGI shows the best antitumor efficacy via chemo‐photothermal therapy compared to other treatment groups in the TNBC model of nude mice. Thus, MSCs‐LDGI multifunctional system represents greatly synergistic potential for cancer treatment.

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“…Therapeutic possibilities of plasmonically heated AuNPs were also reported [9]. Two properties of AuNPs make them suitable candidates for therapeutic applications: (1) antibodies and other biomolecules can easily be attached to the surface of AuNPs; (2) plasmon resonances of AuNPs make them to have photon capture ability that favours the use of nanoparticles superior to photothermal dyes [10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterisation and biocompatibility of surface-functionalised gold nanoparticles

Vijayamma

Kumar

Rejiya

et al. 2011

Journal of Experimental Nanoscience

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Understanding and controlling the interactions between nanoparticles and living cells are of great importance in the diagnosis and therapeutic applications of nanosized materials. This article describes the synthesis, characterisation and interactions of gold nanoparticles (AuNPs) with different in vitro and in vivo experimental models. Preliminary cytotoxicity studies were carried out in tumour ascites (Dalton's lymphoma ascites and Ehrlich's ascites carcinoma) and normal peritoneal cells for different concentrations and it was found that AuNPs did not cause any cell death or morphological changes even at 100 mM concentrations. The tissue distribution and toxicity of intravenously administered AuNPs were investigated in mice because of the fundamental importance of obtaining information about the localisation and biocompatibility of this material. Tissue distribution of AuNPs was studied in normal as well as skin tumour-induced Swiss albino mice using inductively coupled plasma-atomic emission spectrophotometer and transmission electron microscopy. Acute cytotoxicity and histopathology were carried out for toxicity evaluation in AuNP-injected normal mice and found that AuNPs did not cause any significant metabolic change. The health and behaviour of animals were normal throughout the study. The biocompatibility assessment of AuNPs both in vitro and in vivo confirmed that triethylene glycol-functionalised AuNPs are compatible to the biological system and can be used as a safe material for various biological applications.

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A Cellular Trojan Horse for Delivery of Therapeutic Nanoparticles into Tumors

Cited by 537 publications

References 40 publications

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

A Light‐Triggered Mesenchymal Stem Cell Delivery System for Photoacoustic Imaging and Chemo‐Photothermal Therapy of Triple Negative Breast Cancer

Synthesis, characterisation and biocompatibility of surface-functionalised gold nanoparticles

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