A cellular pathway controlling functional plasma membrane incorporation of the cold sensor TRPM8

Functions of sensory TRP channels in vascular responses to chemical and thermal stimuli

“…The activation of these channels leads to the pore opening allowing a cation influx and depolarization of the cell at the resting potential triggering the activation of VDCC and resulting in Ca 2+ entry to the cell [49,60]. The increase of free , TRP proteins are essential for physiological processes including Ca 2+ and Mg 2+ homeostasis, the regulation of smooth muscle contraction, cell proliferation, migration, thermo-, chemo-and mechano-sensation processes and remodelling in pathological conditions [61][62][63][64][65][66].…”

“…TRPM8 is a non-selective cation channel expressed in sensory neurons [149]. It is well known to be activated by cold temperatures and by chemical compounds including menthol, icilin, and several inflammatory agents [63,[150][151][152]. A phosphatidylinositol 4,5-bisphosphate (PIP 2 )-related mechanism has been proposed for the activation of TRPM8.…”