2014
DOI: 10.1371/journal.pone.0092774
|View full text |Cite|
|
Sign up to set email alerts
|

A Cell-Regulatory Mechanism Involving Feedback between Contraction and Tissue Formation Guides Wound Healing Progression

Abstract: Wound healing is a process driven by cells. The ability of cells to sense mechanical stimuli from the extracellular matrix that surrounds them is used to regulate the forces that cells exert on the tissue. Stresses exerted by cells play a central role in wound contraction and have been broadly modelled. Traditionally, these stresses are assumed to be dependent on variables such as the extracellular matrix and cell or collagen densities. However, we postulate that cells are able to regulate the healing process … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
44
1

Year Published

2015
2015
2019
2019

Publication Types

Select...
4
2

Relationship

0
6

Authors

Journals

citations
Cited by 51 publications
(46 citation statements)
references
References 50 publications
1
44
1
Order By: Relevance
“…(2014), Valero et al. (2014) and Gaffney et al. (2002), Maggelakis (2003), Maggelakis (2004) in the context of angiogenesis.…”
Section: Introductionmentioning
confidence: 96%
“…(2014), Valero et al. (2014) and Gaffney et al. (2002), Maggelakis (2003), Maggelakis (2004) in the context of angiogenesis.…”
Section: Introductionmentioning
confidence: 96%
“…In the very early stages, the wound expands a little as a result of the many fibroblasts outside the wound that are pulling. This is believed to trigger differentiation to myofibroblasts, see for instance Valero et al (2014). We did not take this triggering mechanism into account in the present model.…”
Section: Wound Contractionmentioning
confidence: 99%
“…Subsequently, cell differentiation from a fibroblast to a myofibroblast has been incorporated as a stochastic process. It is well-known that differentiation of fibroblasts to myofibroblasts takes place as a result of expansion forces (Valero et al 2014) of the wound and as a result of a high levels of VEGF. Therewith, this differentiation predominantly takes place near the edge of the wound.…”
Section: The Cellular Modelmentioning
confidence: 99%
See 1 more Smart Citation
“…As the fibroblasts move into the wound area, they pull the tissue and under unfavourable chemical and mechanical circumstances they are able to differentiate to myofibroblasts, which are cells that pull at a larger force on the surrounding tissue, produce more, excessive collagen, and furthermore shorten the chemical bonds of the long polymeric chains that constitute the collagen. These chemically and mechanically unfavourable conditions typically refer to the concentration of certain cytokines (growth factors) and/or to pulling forces that the fibroblasts experience, which make them differentiate to myofibroblasts, see [45] for instance for a modelling study. It can be seen that the wound area decreases over time and that the wound region changes shape from the initial rectangular shape to a more star-shape due to the internal forces exerted by the (myo)fibroblasts.…”
Section: Wound Contractionmentioning
confidence: 99%