A cell and transcriptome atlas of the human arterial vasculature
Quanyi Zhao,
Albert Pedroza,
Disha Sharma
et al.
Abstract:SUMMARYVascular beds show different propensities for different vascular pathologies, yet mechanisms explaining these fundamental differences remain unknown. We sought to build a transcriptomic, cellular, and spatial atlas of human arterial cells across multiple different arterial segments to understand this phenomenon. We found significant cell type-specific segmental heterogeneity. Determinants of arterial identity are predominantly encoded in fibroblasts and smooth muscle cells, and their differentially expr… Show more
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