“…Here, too, they present a model for cellular organization and differentiation that incorporates a wealth of nonlinearities, beginning with the asymmetry in cell division that gives rise to the guard mother cell. We dedicate this Focus Issue to the memory of Fred Sack (Bergmann et al, 2017), whose pioneering studies of mutants in stomatal development, as well as his infectious humor and generosity, formed the cornerstone of much research that has followed over the past two decades. The Update review by Chater et al (2017) touches on some of the most recent developments on this topic.…”