A Cecropia peltata ethanolic extract reduces insulin resistance and hepatic steatosis in rats fed a high-fat diet

Duarte-Alonso, Andrea; Cu-Cañetas, Trinidad Eugenia; Ávila-Nava, Azalia; Sansores-España, Delia; Acevedo-Fernández, Juan José; Sandoval-Peraza, Mukthar; Chel‐Guerrero, Luis; Torre-Villalvazo, Iván

doi:10.1016/j.jep.2020.113087

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…Numerous antiobesity and antidiabetic drugs have been developed, such as orlistat, sibutramine, and rimonabant. Because of their serious adverse effects, several alternatives are proposed [ 9 ]. Recently, natural compounds have been used to treat obesity associated with insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway

Hadrich

Mahmoudi

Chamkha

et al. 2023

Oxidative Medicine and Cellular Longevity

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Olive leaves extracts are known to exert potential pharmacological activities especially, antidiabetic and antiobesity. This study explores the anti-insulin resistant effect of olive leaves extracts and oleuropein in 3 T3-L1 cells and in high-fat diet fed rats. Our results showed that ethanol extract (EE) suppressed significantly ( P < 0.01 ) triacylglycerol accumulation. In preadipocytes cells, EE 1/100 decreased cell viability and induced apoptosis. Real-time PCR analysis showed that EE reduced the mRNA levels of adipogenesis (CEBP-α, PPARγ, SREBP-1c, and FAS) and proinflammatory (TNF-α and IL-6) genes. Moreover, the cotreatment of EE 1/1000 or oleuropein with insulin increased considerably the expression of p-IRS, p85-pI3K, and p-AKT. In vivo model, the oral administration of oleuropein at 50 mg/kg in rats fed with high fat diet for 8 weeks reduced inflammation in liver and adipose tissues (WAT), improved glucose intolerance, and decreased hyperinsulinemia. Furthermore, the immunohistochemistry revealed that the expression level of p-Akt, IRS1, and Glut-4 were significantly enhanced in liver and WAT tissues after oleuropein supplementation comparing with that in HFD group. Additionally, the expression of IRS1 was markedly ameliorated in pancreas. Our obtained results can be adopted as an approach to used olive leaves as complement to prevent insulin-resistance disease.

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Section: Introductionmentioning

confidence: 99%

Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway

Hadrich

Mahmoudi

Chamkha

et al. 2023

Oxidative Medicine and Cellular Longevity

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“…En cuanto a la toxicidad de Cecropia (ver tabla 3), la información disponible indica que las hojas pueden causar picor y provocar la aparición de urticaria o ronchas. (78,79,80,81,82,83,84,85,86,87,88) Se ha destacado la importancia de los usos etnomédicos respaldados por estudios basados en marcadores químicos, (66) para el control de calidad de las materias primas de varias especies de Cecropia. Sin embargo, hasta ahora, son limitados los métodos que aseguran su calidad, inocuidad y posibles efectos citotóxicos o antitumorales.…”

Section: Toxicidadunclassified

Cytoprotection of Cecropia obtusifolia Bertol (Cecropiaceae) extract on the normal adherent cell line of human fibroblasts Hs68

Villarreal-Ibarra,

Rivas-Morales,

Leos-Rivas

et al. 2024

Salud, Ciencia y Tecnología - Serie de Conferencias

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El estudio se enfoca en la acción terapéutica de plantas medicinales empleadas en el tratamiento de enfermedades crónico degenerativas. Se evalúo el extracto etanólico de la especie mexicana Cecropia obtusifolia Bertol, utilizada tradicionalmente para la diabetes. El efecto citoprotector, se determinó sobre la línea celular normal adherente de fibroblastos humanos Hs68 y su toxicidad sobre Artemia salina. El efecto citoprotector se realizó mediante el ensayo rojo neutro (RN) con las células antes mencionados con una viabilidad de un 98%, por lo tanto, muy bajo efecto citotóxico y con nula toxicidad sobre A. salina. Estos ensayos han sido empleados de forma rutinaria como métodos de tamizaje de extractos naturales y compuestos puros con efecto potencial en la terapia contra el cáncer.

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“…Male Wistar rats Exposure to high-fat diet with 10 % sugar in the water [121] Brazil were Piper (6 species), Solanum (5 species), Aristolochia and Erythrina (4 species each), Cecropia, Croton, Hyptis, Mimosa, Phyllanthus and Senna (3 species each). About 27.5 % of the cited species had their leaves used, followed by roots/rhizomes (21.5 %), barks (stem, root, wood) (21 %), whole plant (6.5 %), branches (4 %), flowers/inflorescences and aerial parts (4 % each), seeds and fruits (3 % each), latex/juice/sap (2 %), stems (1.5 %), tubers and buds (1 % each), culms and vines (0.5 % each).…”

Section: Solanum Subinermementioning

confidence: 99%

“…The hydroalcoholic extract of C. peltata leaves ('embaúba'), used in folk medicine for hepatitis, [40] promoted a significant reduction in hepatic steatosis in rats subjected to a high-fat diet when administered daily at an oral dose of 10 mg/kg for 90 days. [121] 2.31. Costus spiralis (Jacq.)…”

Section: Cecropia Peltata Lmentioning

confidence: 99%

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

Arbo

Konrath

2022

Chemistry & Biodiversity

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The native flora of Brazil covers a large biodiversity of plants, some of which have important pharmacological properties. Ethnobotanical studies have established that the folk use of plants for hepatobiliary disorders is very common in Brazil. This review aimed to compile, describe and discuss the main native Brazilian medicinal plants used as hepatoprotective agents listed on 25 books by authors from various regions in the country. Based on the 153 species found, a comprehensive analysis of the most relevant scientific studies is presented, including Piper umbellatum, Echinodorus macrophyllus, Fevillea trilobata and Achyrocline satureioides. Some medicinal plants share both a large number of citations and scientific evidence to corroborate their hepatoprotective effects, including Solanum paniculatum, Baccharis crispa and Phyllanthus niruri, which could be of interest to develop new phytomedicines. Additionally, some active ingredients are indicated as being responsible for the liver protective effects described, particularly phenolic compounds (flavonoids, coumestans and lignans).

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A Cecropia peltata ethanolic extract reduces insulin resistance and hepatic steatosis in rats fed a high-fat diet

Cited by 7 publications

References 31 publications

Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway

Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway

Cytoprotection of Cecropia obtusifolia Bertol (Cecropiaceae) extract on the normal adherent cell line of human fibroblasts Hs68

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

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