Abstract:Rif1 mediates telomere length, DNA replication, and DNA damage responses in budding yeast. Previous work identified several posttranslational modifications of Rif1, however none of these was shown to mediate the molecular or cellular responses to DNA damage, including telomere damage. We searched for such modifications using immunoblotting methods and the
cdc13-1
and
tlc1Δ
models of telomere damage. We found that Rif1 is phosphorylated during telomere damage, and t… Show more
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