A CDAHFD-induced mouse model mimicking human NASH in the metabolism of hepatic phosphatidylcholines and acyl carnitines

Abstract

Lipidomics reavealed the differences of lipid signitures in NASH models induced by the MCD and CDAHFD in mice. The hepatic PCs, ACs and their metabolism in CDAHFD-treated mice were down-regulated, mimicking the human NASH.