A CCL chemokine-derived peptide (CDIP-2) exerts anti-inflammatory activity via CCR1, CCR2 and CCR3 chemokine receptors: Implications as a potential therapeutic treatment of asthma

Méndez-Enríquez, Erika; Medina-Tamayo, Jaciel; Soldevila, Gloria; Fortoul, Teresa I.; Antón, Benito; Flores‐Romo, Leopoldo; García‐Zepeda, Eduardo A.

doi:10.1016/j.intimp.2014.01.032

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…A recent article demonstrated that CCL chemokine-derived peptide reduces chemokine-mediated functions through interactions with CCR1, CCR2, and CCR3, reducing cell infiltration and expression of inflammatory mediators related to the hallmarks of asthma. 29 Airway smooth muscle-derived CCL2-mediated activation of CCR2 promotes fibrocyte migration. 30 Targeting chemokine-mediated fibrocyte trafficking to the airways or reduction of chemokine receptor expression might provide novel therapies of airway inflammation and remodeling in asthmatic patients.…”

Section: Discussionmentioning

confidence: 99%

Fibrocyte trafficking in patients with chronic obstructive asthma and during an acute asthma exacerbation

Wang

Punde

Huang

et al. 2015

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 99%

Fibrocyte trafficking in patients with chronic obstructive asthma and during an acute asthma exacerbation

Wang

Punde

Huang

et al. 2015

Journal of Allergy and Clinical Immunology

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“…Nevertheless, the implication of CKR in nonallergic asthma remains to be established. We therefore studied the expression of Th1-typical CKR such as CCR2 [7], CCR5 [4], CCR6 [5,8], and CXCR4 [4,9], as well as CXCR3 (Th2- and Th1-typical CKR) [4,10,11,12,13], in circulating T lymphocytes from nonallergic asthma patients.…”

Section: Introductionmentioning

confidence: 99%

Abnormal Chemokine Receptor Profile on Circulating T Lymphocytes from Nonallergic Asthma Patients

Barbarroja-Escudero

Prieto-Martín

Monserrat-Sanz

et al. 2014

Int Arch Allergy Immunol

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Background: T lymphocytes are involved in the pathogenesis of nonallergic asthma. The objective of this study was to characterize the subset distribution and pattern of chemokine receptor expression in circulating T lymphocyte subsets from nonallergic asthma patients. Methods: Forty stable nonallergic asthma patients and 16 sex- and age-matched healthy donors were studied. Twelve patients did not receive inhaled steroids (untreated patients), 16 received 50-500 μg b.i.d. of inhaled fluticasone propionate (FP) (standard-dose patients), and 12 received over 500 μg b.i.d. of inhaled FP (high-dose patients) for at least 12 months prior to the beginning of this study and were clinically well controlled. Flow cytometry was performed using a panel of monoclonal antibodies (4 colors). Results: Nonallergic asthma patients treated with high doses of inhaled FP showed a significant reduction in the percentages of CD3+ T lymphocytes compared to healthy controls. Untreated patients showed a significant increase in CCR6 expression in CD8+CD25+ and CD8+CD25+bright T cells compared to healthy controls. The results were similar for CXCR3 and CCR5 expression. In patients treated with standard doses of FP, CCR5 expression was significantly increased in CD3+ T lymphocytes relative to healthy controls. Conclusions: The different groups of clinically stable nonallergic asthmatic patients showed distinct patterns of alterations in subset distribution as well as CCR6, CXCR3, and CCR5 expression on circulating T lymphocytes.

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“…We found that 9 cytokines were significantly higher in the M2a hMdɸ‒ conditioned medium, while 15 cytokines were significantly higher in the M1 hMdɸ‒ conditioned medium (Table 2). Several of the 9 cytokines that were increased in the M2a hMdɸ‒conditioned medium were previously reported to play a role in various inflammatory processes, including ocular inflammatory diseases and neurodegenerative diseases; these cytokines include eotaxin (Deng et al 2019; Mor et al 2019; Segal-salto et al 2019; Shoji et al 2017; Zeng et al 2019), MCP-4 (El-asrar et al 2019; Méndez-enríquez et al 2014; Mendez-Enriquez et al 2013; Zeng et al 2019), TARC (Dai et al , 2015; Yu et al , 2011; Zeng et al , 2019), MPIF-1 (Faura,et al2020; Simats et al 2018; Zeng et al 2019), and HCC-1 (Liu et al , 2016).…”

Section: Resultsmentioning

confidence: 99%

CCR1 Mediates Müller Cell Activation and Photoreceptor Cell Death in Macular and Retinal Degeneration

Elbaz-Hayoun

Rinsky

Hagbi-Levi

et al. 2023

Preprint

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Mononuclear cells are involved in the pathogenesis of retinal diseases, including age-related macular degeneration (AMD). Here, we examined the mechanisms that underlie macrophage-driven retinal cell death. Monocytes were extracted from patients with AMD and differentiated into macrophages (hMdΦs), which were characterized based on proteomics, gene expression, and ex vivo and in vivo properties. Using bioinformatics, we identified the signaling pathway involved in macrophage-driven retinal cell death, and we assessed the therapeutic potential of targeting this pathway. We found that M2a hMdΦs were associated with retinal cell death in retinal explants and following adoptive transfer in a photic injury model. Moreover, M2a hMdΦs express several CCRI (C-C chemokine receptor type 1) ligands. Importantly, CCR1 was upregulated in Müller cells in models of retinal injury and aging, and CCR1 expression was correlated with retinal damage. Lastly, inhibiting CCR1 reduced photic-induced retinal damage, photoreceptor cell apoptosis, and retinal inflammation. These data suggest that hMdΦs, CCR1, and Müller cells work together to drive retinal and macular degeneration, suggesting that CCR1 may serve as a target for treating these sight-threatening conditions.

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A CCL chemokine-derived peptide (CDIP-2) exerts anti-inflammatory activity via CCR1, CCR2 and CCR3 chemokine receptors: Implications as a potential therapeutic treatment of asthma

Cited by 8 publications

References 40 publications

Fibrocyte trafficking in patients with chronic obstructive asthma and during an acute asthma exacerbation

Fibrocyte trafficking in patients with chronic obstructive asthma and during an acute asthma exacerbation

Abnormal Chemokine Receptor Profile on Circulating T Lymphocytes from Nonallergic Asthma Patients

CCR1 Mediates Müller Cell Activation and Photoreceptor Cell Death in Macular and Retinal Degeneration

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