A cavalry fort on the northern frontier and the chronology of Flavian Scotland - W. S. HANSON, with K. SPELLER, P. A. YEOMAN and J. TERRY, and contributions by L. Allason-Jones, J. D. Bateson, A. J. Clapham, P. A. Clarke, B. A. Crone, C. Dickson, S. J. Dockrill, J. Dore, S. Garside-Neville, J. A. Gater, W. Groenman-van Waateringe, B. R. Hartley, K. Hartley, M. Henig, D. Jordan, G. MacGregor, E. W. Mackie, G. S. Maxwell, A. S. Penn, J. Price, R. J. Price, E. A. Slater, C. Smith, R. S. O. Tomlin, J. P. Wild,

Jones, Rebecca H.

doi:10.1017/s1047759400021346

Cited by 35 publications

(53 citation statements)

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“…In this molecular formula, n is the number of carbon atoms, and z is zero or a negative even integer that represents the hydrogen deficiency resulting from formation of cyclic rings in the structures [2]. The definition of NAs has recently been expanded to include not only O2NAs, but also the unsaturated and aromatic NA-like compounds, the compounds with increased numbers of oxygen atoms in the formula (also referred as oxygenated NAs; OxNAs, x is an integer of Ͼ2), as well as the compounds that contain heterogeneous atoms such as nitrogen (N) and/or sulfur (S) [3,4].…”

Section: Introductionmentioning

confidence: 99%

Molecular profiling of naphthenic acids in technical mixtures and oil sands process‐affected water using polar reversed‐phase liquid chromatography–mass spectrometry

Han

Lin

et al. 2016

Electrophoresis

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In this work, a reversed-phase ultra-HPLC (UHPLC) ultrahigh resolution MS (UHRMS) method was evaluated for the comprehensive profiling of NAs containing two O atoms in each molecule (O2NAs; general formula C H O , where n is the number of carbon atoms and z represents hydrogen deficiency). Using a polar cyanopropyl-bonded phase column and negative-ion electrospray ionization mass spectrometric detection at 120,000 FWHM (m/z 400), 187 and 226 O2NA species were found in two naphthenic acid technical mixtures, and 424 and 198 species with molecular formulas corresponding to O2NAs were found in two oil sands process-affected water samples (one from a surface mining operation and the other from a steam-assisted gravity drainage operation), respectively. To our knowledge, these are the highest numbers of molecular compositions of O2NAs that have been profiled thus far in environmental samples. Assignments were based on accurate mass measurements (≤3 ppm) combined with rational molecular formula generation, correlation of chromatographic behavior of O2NA homologues with their elemental compositions, and confirmation with carboxyl group-specific chemical derivatization using 3-nitrophenylhydrazine. Application of this UHPLC-UHRMS method to the quantitation of O2NAs in the surface mining operation-derived water sample showed excellent linearity (R = 0.9999) with external calibration, a linear range of 256-fold in concentration, and quantitation accuracies of 64.9 and 69.4% at two "standard substance" spiking levels.

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Section: Introductionmentioning

confidence: 99%

Molecular profiling of naphthenic acids in technical mixtures and oil sands process‐affected water using polar reversed‐phase liquid chromatography–mass spectrometry

Han

Lin

et al. 2016

Electrophoresis

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“…carotovora is encoded by the carI gene, the activation of which is induced in response to an increase in cell density. Production and accumulation of AHL and resultant activation of target genes leads to production of various exoenzymes, namely pectinases and proteases [108]. Quorum-sensing regulation of pathogenesis in Er.…”

Section: Carbapenemmentioning

confidence: 99%

Microbial quorum sensing: a tool or a target for antimicrobial therapy?

Raina

Vizio

Odell

et al. 2009

Biotech and App Biochem

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Inter-cell communication aided by released chemical signals when cell density reaches a critical concentration has been investigated for over 30 years as quorum sensing. Originally discovered in Gram-negative bacteria, quorum-sensing systems have also been studied extensively in Gram-positive bacteria and dimorphic fungi. Microbial communities communicating via quorum sensing employ various chemical signals to supervise their surrounding environment, alter genetic expression and gain advantage over their competitors. These signals vary from acylhomoserine lactones to small modified or unmodified peptides to complex gamma-butyrolactone molecules. The scope of this review is to give an insight into some of the quorum-sensing systems now known and to explore their role in microbial physiology and development of pathogenesis. Particular attention will be dedicated to the signalling molecules involved in quorum-sensing-mediated processes and the potential shown by some of their natural and synthetic analogues in the treatment of infections triggered by quorum sensing.

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“…[8] To gain atomic level structural insights into PrP23-144 amyloid propagation we have carried out a series of solid-state nuclear magnetic resonance (NMR) studies for a set of homologous recombinant proteins corresponding to the human, mouse and Syrian hamster amino acid sequences as well as related mutants. [9][10][11][12][13][14][15] These studies concluded that huPrP23-144 fibrils consist of two protofilaments, where each protofilament contains a structured compact core region of 30 amino acids (aa) spanning residues~112-141 with parallel in-register b-sheet architecture and a large dynamically disor-dered~90-residue N-terminal tail domain.…”

Section: Introductionmentioning

confidence: 99%

Conformational Dynamics in the Core of Human Y145Stop Prion Protein Amyloid Probed by Relaxation Dispersion NMR

et al. 2018

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Microsecond to millisecond timescale backbone dynamics of the amyloid core residues in Y145Stop human prion protein (PrP) fibrils were investigated by using 15N rotating frame (R1ρ) relaxation dispersion solid‐state nuclear magnetic resonance spectroscopy over a wide range of spin‐lock fields. Numerical simulations enabled the experimental relaxation dispersion profiles for most of the fibril core residues to be modelled by using a two‐state exchange process with a common exchange rate of 1000 s−1, corresponding to protein backbone motion on the timescale of 1 ms, and an excited‐state population of 2 %. We also found that the relaxation dispersion profiles for several amino acids positioned near the edges of the most structured regions of the amyloid core were better modelled by assuming somewhat higher excited‐state populations (∼5–15 %) and faster exchange rate constants, corresponding to protein backbone motions on the timescale of ∼100–300 μs. The slow backbone dynamics of the core residues were evaluated in the context of the structural model of human Y145Stop PrP amyloid.

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Cited by 35 publications

References 0 publications

Molecular profiling of naphthenic acids in technical mixtures and oil sands process‐affected water using polar reversed‐phase liquid chromatography–mass spectrometry

Molecular profiling of naphthenic acids in technical mixtures and oil sands process‐affected water using polar reversed‐phase liquid chromatography–mass spectrometry

Microbial quorum sensing: a tool or a target for antimicrobial therapy?

Conformational Dynamics in the Core of Human Y145Stop Prion Protein Amyloid Probed by Relaxation Dispersion NMR

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