A cautionary note on altered pace of aging in the COVID-19 era

Attia, MennattAllah Hassan

doi:10.1016/j.fsigen.2022.102724

Cited by 3 publications

(3 citation statements)

References 67 publications

(150 reference statements)

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“…Epigenetic markers of disease severity are concentrated near promoter regions (including the promoters of certain aging-related genes [ 48 ]) and include the hypermethylation of IFN-related and the hypomethylation of inflammatory genes [ 49 , 50 ]. In turn, COVID-19 might influence the markers included in biological age estimators and possibly, the process of aging as well [ 51 , 52 ].…”

Section: Host Factorsmentioning

confidence: 99%

“…Both COPD and asthma are chronic lung diseases involving shortness of breath, chest tightness, wheezing and cough, but the causes and mechanisms of the two conditions are largely different. As opposed to COPD, in allergic (atopic) asthma ACE2 levels are decreased both in upper and lower airways [ 216 , 236 , 237 ], inflammation is characterized by a type 2 [ 238 ] instead of a type 1 response, and T cell levels are not decreased [ 26 , 52 ]. A component of type 2 inflammation, eosinophilia has been shown to be independently associated with decreased severity of COVID-19 [ 239 ].…”

Section: Host Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors

Zsichla

Müller

2023

Viruses

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The clinical course and outcome of COVID-19 are highly variable, ranging from asymptomatic infections to severe disease and death. Understanding the risk factors of severe COVID-19 is relevant both in the clinical setting and at the epidemiological level. Here, we provide an overview of host, viral and environmental factors that have been shown or (in some cases) hypothesized to be associated with severe clinical outcomes. The factors considered in detail include the age and frailty, genetic polymorphisms, biological sex (and pregnancy), co- and superinfections, non-communicable comorbidities, immunological history, microbiota, and lifestyle of the patient; viral genetic variation and infecting dose; socioeconomic factors; and air pollution. For each category, we compile (sometimes conflicting) evidence for the association of the factor with COVID-19 outcomes (including the strength of the effect) and outline possible action mechanisms. We also discuss the complex interactions between the various risk factors.

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Section: Host Factorsmentioning

confidence: 99%

Section: Host Factorsmentioning

confidence: 99%

Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors

Zsichla

Müller

2023

Viruses

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“…More recently, concerns were raised regarding the effect of SARS‐CoV‐2 on the DNA methylation of age markers [88]. Clinical research shows that COVID‐19 virus and medical management may affect the DNA methylation levels on certain CpG loci resulting in statistically significant changes to epigenetic age clocks [89].…”

Section: Current Forensic Applicationsmentioning

confidence: 99%

Pyrosequencing: Current forensic methodology and future applications—a review

et al. 2022

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The recent development of small, single-amplicon-based benchtop systems for pyrosequencing has opened up a host of novel procedures for applications in forensic science. Pyrosequencing is a sequencing by synthesis technique, based on chemiluminescent inorganic pyrophosphate detection. This review explains the pyrosequencing workflow and illustrates the step-by-step chemistry, followed by a description of the assay design and factors to keep in mind for an exemplary assay. Existing and potential forensic applications are highlighted using this technology. Current applications include identifying species, identifying bodily fluids, and determining smoking status. We also review progress in potential applications for the future, including research on distinguishing monozygotic twins, detecting alcohol and drug abuse, and other phenotypic characteristics such as diet and body mass index. Overall, the versatility of the pyrosequencing technologies renders it a useful tool in forensic genomics.

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Uncovering Forensic Evidence: A Path to Age Estimation through DNA Methylation

Castagnola,

Medina-Paz,

Zapico

2024

IJMS

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Age estimation is a critical aspect of reconstructing a biological profile in forensic sciences. Diverse biochemical processes have been studied in their correlation with age, and the results have driven DNA methylation to the forefront as a promising biomarker. DNA methylation, an epigenetic modification, has been extensively studied in recent years for developing age estimation models in criminalistics and forensic anthropology. Epigenetic clocks, which analyze DNA sites undergoing hypermethylation or hypomethylation as individuals age, have paved the way for improved prediction models. A wide range of biomarkers and methods for DNA methylation analysis have been proposed, achieving different accuracies across samples and cell types. This review extensively explores literature from the past 5 years, showing scientific efforts toward the ultimate goal: applying age prediction models to assist in human identification.

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A cautionary note on altered pace of aging in the COVID-19 era

Cited by 3 publications

References 67 publications

Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors

Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors

Pyrosequencing: Current forensic methodology and future applications—a review

Uncovering Forensic Evidence: A Path to Age Estimation through DNA Methylation

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