A Catheter-related Bloodstream Infection With Mycobacterium frederiksbergense in an Immunocompromised Child

Senozan, Erin A.; Adams, Daniel J.; Giamanco, Nicole; Warwick, Anne B.; Eberly, Matthew D.

doi:10.1097/inf.0000000000000563

Cited by 5 publications

(5 citation statements)

References 14 publications

(1 reference statement)

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“…The two dominant Mycobacteriumlike OTUs from all sampling dates and mains were M. f rederiksbergense (83.3%) and M. aurum (11.4%). Although M. f rederiksbergense has been isolated in association with a catheterrelated infection 61 and two subcutaneous injection-related infections, 62 this Mycobacterium sp. is not generally recognized as a pathogen.…”

Section: ■ Discussionmentioning

confidence: 99%

Sulfate Reducing Bacteria and Mycobacteria Dominate the Biofilm Communities in a Chloraminated Drinking Water Distribution System

Gomez-Smith

LaPara

Hozalski

2015

Environ. Sci. Technol.

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The quantity and composition of bacterial biofilms growing on 10 water mains from a full-scale chloraminated water distribution system were analyzed using real-time PCR targeting the 16S rRNA gene and next-generation, high-throughput Illumina sequencing. Water mains with corrosion tubercles supported the greatest amount of bacterial biomass (n = 25; geometric mean = 2.5 × 10(7) copies cm(-2)), which was significantly higher (P = 0.04) than cement-lined cast-iron mains (n = 6; geometric mean = 2.0 × 10(6) copies cm(-2)). Despite spatial variation of community composition and bacterial abundance in water main biofilms, the communities on the interior main surfaces were surprisingly similar, containing a core group of operational taxonomic units (OTUs) assigned to only 17 different genera. Bacteria from the genus Mycobacterium dominated all communities at the main wall-bulk water interface (25-78% of the community), regardless of main age, estimated water age, main material, and the presence of corrosion products. Further sequencing of the mycobacterial heat shock protein gene (hsp65) provided species-level taxonomic resolution of mycobacteria. The two dominant Mycobacteria present, M. frederiksbergense (arithmetic mean = 85.7% of hsp65 sequences) and M. aurum (arithmetic mean = 6.5% of hsp65 sequences), are generally considered to be nonpathogenic. Two opportunistic pathogens, however, were detected at low numbers: M. hemophilum (arithmetic mean = 1.5% of hsp65 sequences) and M. abscessus (arithmetic mean = 0.006% of hsp65 sequences). Sulfate-reducing bacteria from the genus Desulfovibrio, which have been implicated in microbially influenced corrosion, dominated all communities located underneath corrosion tubercules (arithmetic mean = 67.5% of the community). This research provides novel insights into the quantity and composition of biofilms in full-scale drinking water distribution systems, which is critical for assessing the risks to public health and to the water supply infrastructure.

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Section: ■ Discussionmentioning

confidence: 99%

Sulfate Reducing Bacteria and Mycobacteria Dominate the Biofilm Communities in a Chloraminated Drinking Water Distribution System

Gomez-Smith

LaPara

Hozalski

2015

Environ. Sci. Technol.

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“…M. frederiksbergense was first isolated from soil in Denmark (Willumsen et al 2001). This species has been confirmed to potentially lead to infection while being sensitive to drugs commonly used to treat non-tuberculous mycobacteria (Senozan et al 2015). Brevundimonas spp.…”

Section: Resultsmentioning

confidence: 99%

Antibiotic and Disinfectant Resistance in Tap Water Strains – Insight into the Resistance of Environmental Bacteria

Siedlecka

Wolf-Baca

Piekarska

2021

Polish Journal of Microbiology

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Although antibiotic-resistant bacteria (ARB) have been isolated from tap water worldwide, the knowledge of their resistance patterns is still scarce. Both horizontal and vertical gene transfer has been suggested to contribute to the resistance spread among tap water bacteria. In this study, ARB were isolated from finished water collected at two independent water treatment plants (WTPs) and tap water collected at several point-of-use taps during summer and winter sampling campaigns. A total of 24 strains were identified to genus or species level and subjected to antibiotic and disinfectant susceptibility testing. The investigated tap water ARB belonged to phyla Proteobacteria, Bacteroidetes, Actinobacteria, and Firmicutes. The majority of the isolates proved multidrug resistant and resistant to chemical disinfectant. Neither seasonal nor WTP-dependent variabilities in antibiotic or disinfectant resistance were found. Antibiotics most effective against the investigated isolates included imipenem, tetracyclines, erythromycin, and least effective – aztreonam, cefotaxime, amoxicillin, and ceftazidime. The most resistant strains originate from Afipia sp. and Methylobacterium sp. Comparing resistance patterns of isolated tap water ARB with literature reports concerning the same genera or species confirms intra-genus or even intra-specific variabilities of environmental bacteria. Neither species-specific nor acquired resistance can be excluded.

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“…Es importante que el personal del laboratorio esté familiarizado con cepas tipo Mycobacterium fortuitum y Mycobacterium chelonae. En este estudio también hemos identificado a Mycobacterium frederiksbergense, una cepa aislada por primera vez en Dinamarca en 2001; la cual recientemente ha sido implicada en infecciones en humanos, en especial en un paciente pediátrico con leucemia linfoblástica aguda (25). Así Mycobacterium canariasense fue aislada más de una vez del agua del hospital.…”

Section: Las Micobacterias Patógenas Han Sido Aisladasunclassified

Aislamiento y caracterización molecular de micobacterias no tuberculosas en el sistema de distribución de agua en un hospital de Lima (Perú).

Cabello‐Vílchez

Núñez-Ato

2018

biosalud

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Introducción: Las infecciones por micobacterias pueden causar lesiones cutáneas y pulmonares; las micobacterias pueden hallarse en fuentes de agua intrahospitalarias, pudiendo llegar a los pacientes inmunosuprimidos y provocar enfermedades severas. Objetivo: Aislar y caracterizar micobacterias no tuberculosas en el sistema de distribución de agua en un hospital de Lima. Materiales y métodos: Se aislaron las micobacterias en medios convencionales a base de huevo; y se emplearon pruebas bioquímicas y herramientas moleculares como la reacción en cadena de la polimerasa ―PCR― y secuenciación para su identificación. Para el análisis de secuenciación se empleó el GenBank y para el árbol filogenético se utilizó MEGA 6. Resultados: Fue posible el aislamiento de bacilos ácido alcohol resistentes en muestras de agua potable fría, aunque no en agua caliente del hospital. Se aislaron e identificaron varias especies de micobacterias no tuberculosas en las muestras de agua, siendo el 100 % de crecimiento rápido, estas fueron: Mycobacterium canariasense; M. frederiksbergense; M. mucogenicum; Mycobacterium fortuitum y Mycobacterium chelonae. Conclusiones: Esta es la primera vez que se aíslan micobacterias en agua potable de un hospital en Perú. Se concluye que la existencia de micobacterias en el agua del hospital podría ser fuente potencial de brotes nosocomiales, por lo que debería tenerse en cuenta su estudio periódicamente.

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A Catheter-related Bloodstream Infection With Mycobacterium frederiksbergense in an Immunocompromised Child

Cited by 5 publications

References 14 publications

Sulfate Reducing Bacteria and Mycobacteria Dominate the Biofilm Communities in a Chloraminated Drinking Water Distribution System

Sulfate Reducing Bacteria and Mycobacteria Dominate the Biofilm Communities in a Chloraminated Drinking Water Distribution System

Antibiotic and Disinfectant Resistance in Tap Water Strains – Insight into the Resistance of Environmental Bacteria

Aislamiento y caracterización molecular de micobacterias no tuberculosas en el sistema de distribución de agua en un hospital de Lima (Perú).

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