A catechol antioxidant protocatechuic acid potentiates inflammatory leukocyte-derived oxidative stress in mouse skin via a tyrosinase bioactivation pathway

Nakamura, Yoshimasa; Torikai, Koji; Ohigashi, Hajime

doi:10.1016/s0891-5849(01)00481-6

Cited by 41 publications

(32 citation statements)

References 39 publications

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“…However, for the completeness of information, we have to point out that other studies have reported opposite effects of PCA [172]; this discrepancy might be due to the dosage of PCA and the cell type used.…”

Section: Pca Nuclear Factor-b and Mapksmentioning

confidence: 99%

Protocatechuic Acid and Human Disease Prevention: Biological Activities and Molecular Mechanisms

Santangelo²,

et al. 2012

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Epidemiological evidence has shown that a high dietary intake of vegetables and fruit rich in polyphenols is associated with a reduction of cancer incidence and mortality from coronary heart disease. The healthy effects associated with polyphenol consumption have made the study of the mechanisms of action a matter of great importance. In particular, the hydroxybenzoic acid protocatechuic acid (PCA) has been eliciting a growing interest for several reasons. Firstly, PCA is one of the main metabolites of complex polyphenols such as anthocyanins and procyanidins that are normally found at high concentrations in vegetables and fruit, and are absorbed by animals and humans. Since the daily intake of anthocyanins has been estimated to be much higher than that of other polyphenols, the nutritional value of PCA is increasingly recognized. Secondly, a growing body of evidence supports the concept that PCA can exert a variety of biological effects by acting on different molecular targets. It has been shown that PCA possesses antioxidant, anti-inflammatory as well as antihyperglycemic and neuroprotective activities. Furthermore, PCA seems to have chemopreventive potential because it inhibits the in vitro chemical carcinogenesis and exerts pro-apoptotic and anti-proliferative effects in different tissues. This review is aimed at providing an up-dated and comprehensive report on PCA giving a special emphasis on its biological activities and the molecular mechanisms of action most likely responsible for a beneficial role in human disease prevention.

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Section: Pca Nuclear Factor-b and Mapksmentioning

confidence: 99%

Protocatechuic Acid and Human Disease Prevention: Biological Activities and Molecular Mechanisms

Santangelo²,

et al. 2012

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“…49 Dose-dependent effect of protocatechuic acid was confirmed by alterations in the skin of mice after exposure to TPA. 32,48 Several independent in vivo experiments showed that when given protocatechuic acid at doses of 1600 and 20,000nM for 0.5 or 3 hours before application of TPA, the oxidative stress and inflammation were potentiated in the skin. Increased levels of lipid peroxidation, H 2 O 2 generation, and myeloperoxidase activity, and decreased levels of GSH were also observed.…”

Section: Effects Of Protocatechuic Acid On the Redox Balance In Cellsmentioning

confidence: 99%

Potential Cancer Chemopreventive Activity of Protocatechuic Acid

Tanaka

2011

Journal of Experimental & Clinical Medicine

144

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“…chlorogenic and rosmarinic acids, are a therapeutically important group of plant metabolites. These compounds possess long-known anti-inflammatory, cholagogic, spasmolytic, hypolipemic and antiaggregatory properties (De Graff et al 2003;Ekiert and Czygan 2007;Nakamura et al 2001;Sroka and Cisowski 2003). More recent studies have also revealed significant antioxidant, anti-free radical, immunostimulating and anticancer activities of some representatives of this group, e.g.…”

Section: Introductionmentioning

confidence: 99%

Production of biologically active phenolic acids in Aronia melanocarpa (Michx.) Elliott in vitro cultures cultivated on different variants of the Murashige and Skoog medium

Szopa

2013

Plant Growth Regul

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Phenolic acids, both benzoic and cinnamic acid derivatives, are plant metabolites with high therapeutic and cosmetic values. Methanolic extracts from the biomass of shoot and callus cultures of Aronia melanocarpa growing on seven variants of the Murashige and Skoog (MS) medium with different concentrations of plant growth regulators, BA and NAA, ranging from 0.1 to 3.0 mg l -1 , were examined for the production of free phenolic acids and cinnamic acid using the high-performance liquid chromatography (HPLC) method. The extracts from the shoot and callus cultures were confirmed to contain five of the twelve compounds tested for: caffeic, p-coumaric, p-hydroxybenzoic, syringic and vanillic acids. The shoot extracts contained additionally salicylic acid. Both the total amounts and the amounts of individual compounds in either the shoot or callus extracts were dependent on the concentration of cytokinin and auxin in the MS medium variants. The total amounts in the shoot and callus cultures were in the range from 93.52 to 217.00 mg 100 g -1 DW and from 47.11 to 83.83 mg 100 g -1 DW, respectively. The amounts of individual compounds showed wide variation, from 1.31 to 91.86 mg 100 g -1 DW in the shoot extracts, and from 2.58 to 40.16 mg 100 g -1 DW in the callus extracts. Salicylic acid (max. 91.86 mg 100 g -1 DW), p-coumaric acid (max. 62.39 mg 100 g -1 DW) and p-hydroxybenzoic acid (max. 50.66 mg 100 g -1 DW) dominated in the shoot extracts, while syringic acid (max. 40.16 mg 100 g -1 DW) and p-hydroxybenzoic acid (max. 23.59 mg 100 g -1 DW) were the main metabolites in the callus extracts. This is the first report on the quantitative analysis of benzoic and cinnamic acid derivatives in shoot and callus cultures of A. melanocarpa growing on MS-based media with different concentrations of selected plant growth regulators-BA and NAA. The obtained maximum amounts of some metabolites are of interest from a practical perspective.

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A catechol antioxidant protocatechuic acid potentiates inflammatory leukocyte-derived oxidative stress in mouse skin via a tyrosinase bioactivation pathway

Cited by 41 publications

References 39 publications

Protocatechuic Acid and Human Disease Prevention: Biological Activities and Molecular Mechanisms

Protocatechuic Acid and Human Disease Prevention: Biological Activities and Molecular Mechanisms

Potential Cancer Chemopreventive Activity of Protocatechuic Acid

Production of biologically active phenolic acids in Aronia melanocarpa (Michx.) Elliott in vitro cultures cultivated on different variants of the Murashige and Skoog medium

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