A catalogue of Triticum monococcum genes encoding toxic and immunogenic peptides for celiac disease patients

Vaccino, P.; Becker, Heinz-Albert; Brandolini, Andrea; Salamini, F.; Kilian, Benjamin

doi:10.1007/s00438-008-0412-8

Cited by 57 publications

(35 citation statements)

References 66 publications

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“…Small‐intestinal gluten‐specific T‐cell lines from coeliac patients challenged with one T. monococcum accession by proliferation assay triggered heterogeneous responses in a wide range of stimulation indices, thus indicating potential toxicity . Furthermore, the sequencing of T. monococcum cDNA clones related to storage protein genes revealed the presence of four toxic and 13 immunogenic peptides belonging to all storage protein classes, therefore indicating that einkorn has the full potential to induce coeliac disease syndrome.…”

Section: Adverse Reactionsmentioning

confidence: 99%

Nutritional properties of einkorn wheat (Triticum monococcum L.)

2013

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The hulled wheat einkorn (Triticum monococcum L. ssp. monococcum), a staple food of early farmers for many thousand years, today is cropped only in small areas of the Mediterranean region and continental Europe. Increasing attention to the nutritional quality of foods has fostered renewed interest in this low-impact crop. The reappraisal of einkorn quality evidenced that this ancient wheat has some dietary advantages over polyploid wheats. Einkorn wholemeal is poor in dietary fibre but rich in proteins, lipids (mostly unsaturated fatty acids), fructans and trace elements (including zinc and iron). The good concentration of several antioxidant compounds (carotenoids, tocols, conjugated polyphenols, alkylresorcinols and phytosterols) and low β-amylase and lipoxygenase activities (which limit antioxidant degradation during food processing) contribute to the excellent nutritional properties of its flour, superior to those of other wheats. Conversely, einkorn has relatively low bound polyphenol content and high polyphenol oxidase activity. In spite of eliciting weaker toxic reactions than other Triticum species, einkorn is not suitable for coeliacs. Current trends towards the consumption of functional foods suggest that this cereal may still play a significant role in human consumption, especially in the development of new or special foods with superior nutritional quality.

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Section: Adverse Reactionsmentioning

confidence: 99%

Nutritional properties of einkorn wheat (Triticum monococcum L.)

2013

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“…Chronic symptoms of celiac disease are intestinal pain, diarrhea, head ache, growth retardation, osteoporosis, infertility, lymphoma, and other diseases. It occurs in genetically susceptible children and adults no less than allergies in most parts of the world (Vader et al, 2003;Wieser, Koehler 2008;Camarca et al, 2009;Cummins, Rob erts Thomson, 2009;Vaccino et al, 2009;Xie et al, 2010;Zingone et al, 2010). Unfortunately, we could not find information in the available literature on the frequency of occurrence of allergies and celiac disease in Russia.…”

Section: Introductionmentioning

confidence: 79%

Wheat breeding for resistance to the Sunn pest (Eurygaster spp.): Does risk occur?

Krupnov

2012

Russ J Genet Appl Res

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Wheat is among the most valuable daily foodstuff items. However, it induces allergies or celiac dis ease in approximately 1 out of 100 persons, most often in children. In many regions, harmful Sunn bugs con siderably reduce crop yield and grain quality. Climate warming provides favorable conditions for the expan sion of the geographic range of these bugs and "enhances their harmfulness." There are two major approaches to tackling this problem: genetic protection of the plant itself and genetic protection of the seed, i.e., the prog eny. The former approach appears to be less risky to human health. Wheat requires protection against Sunn bugs that impairs neither the gluten rheology nor the nutritional value of the grain. The basic method is the development of an integrated system for controlling bugs that would include, in addition to technological, biological, and chemical methods, genetic protection. Taken together, these components allow the cultiva tion of environmentally safe wheat. It is also relevant to develop wheat cultivars with reduced contents of allergy and celiac disease determinants.

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“…tauschii (Spaenij-Dekking et al, 2005;van Herpen et al 2006;Vaccino et al 2009). Our previous study revealed that the α-gliadin sequences from V genome of Dasypyrum present Glia-α epitope (Li et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Molecular Characterization and Evolutionary Analysis of Alpha-gliadin Genes from Eremopyrum bonaepartis (Triticeae)

Zhang²,

Ban

et al. 2010

JAS

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Total 16 α-gliadin gene sequences ranged from 1186 to 1316bp were isolated from Eremopyrum bonaepartis by PCR based strategy. Analysis of deduced amino acid sequences indicated that 8 of 16 sequences displayed the typical structure of α-gliadin genes with six cysteine residues, while the other 8 sequences contained in-frame stop codon, and were therefore pseudogenes. Phylogenetic analysis based on the variation of α-gliadin gene sequences indicated that the F genome of E. bonaepartis was apparently differed from the A, B and D genomes of wheat. Four peptides, Glia-α, Glia-α2, Glia-α9 and Glia-α20, which have been identified as T cell stimulatory epitopes in celiac disease (CD) patients through binding to HLA-DQ2/8, were searched to the E. bonaepartis α-gliadin gene sequences. We firstly found that only Glia-α existed in 7 of 8 full sequences, the fact suggesting that the occurrence of the stimulatory epitopes in α-gliadin genes was newly evolved in wheat.

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A catalogue of Triticum monococcum genes encoding toxic and immunogenic peptides for celiac disease patients

Cited by 57 publications

References 66 publications

Nutritional properties of einkorn wheat (Triticum monococcum L.)

Nutritional properties of einkorn wheat (Triticum monococcum L.)

Wheat breeding for resistance to the Sunn pest (Eurygaster spp.): Does risk occur?

Molecular Characterization and Evolutionary Analysis of Alpha-gliadin Genes from Eremopyrum bonaepartis (Triticeae)

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