A Cast of Shadow on Postoperative Radiotherapy for pIIIA-N2 Non–Small Cell Lung Cancer?

Canova, Stefania; Arcangeli, Stefano

doi:10.1001/jamaoncol.2022.4442

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…However, radiotherapy was excluded in the Impower 010 study, and a higher percentage of patients in the best supportive care group (18%) received subsequent radiotherapy for local or distant relapse. Subsequent studies have highlighted the synergistic interaction between radiotherapy and immunotherapy, supporting not only their combined efficacy but also their safety [33][34][35].…”

Section: Immunotherapies and Postoperative Radiotherapymentioning

confidence: 99%

Is there role of adjuvant radiotherapy after complete resection of locally advanced nonsmall cell lung cancer?

Jiang,

Meng

2023

Current Opinion in Oncology

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Purpose of review This review aims to provide a timely and relevant overview of the role of postoperative radiotherapy (PORT) in completely resected stage IIIA-N2 nonsmall cell lung cancer (NSCLC). Given the controversy surrounding the use of PORT and the emergence of advanced radiation techniques and therapies, this review provides valuable insight into current and potential treatment strategies. Recent findings The Lung ART and PORT-C trials have provided valuable insights into the efficacy of PORT in stage IIIA-N2 NSCLC. While the results have been mixed, studies have shown that advanced radiation techniques, such as intensity-modulated radiotherapy (IMRT) and proton therapy, can reduce cardiopulmonary toxicities associated with PORT. Molecular targeted therapies and immunotherapies have also shown potential in improving NSCLC treatment outcomes. Summary The role of radiotherapy becomes smaller and smaller in new era. However, it is too early to abolish radiotherapy for all the patients after complete resection of locally advanced NSCLC. Nowadays, it is recommended to adopt individualized treatment approaches guided by multidisciplinary team consultations. The integration of IMRT, proton therapy, and emerging therapies offers the potential to enhance treatment efficacy while minimizing toxicity. Further research is needed to optimize the use of PORT and explore the method to identify the patients who can really benefit from PORT.

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Section: Immunotherapies and Postoperative Radiotherapymentioning

confidence: 99%