A case series of negative pressure wound therapy as a promising treatment in patients with burn injury

Seswandhana, Rosadi; Anzhari, Sharfan; Dachlan, Ishandono; Wirohadidjojo, Yohanes Widodo; Aryandono, Teguh

doi:10.1016/j.ijscr.2020.03.034

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…We changed the honey wound dressing every five days as inpatient treatment because we combined honey wound dressing with wall suction VAC that could remove fluid from an open wound [17] . Plastic, reconstructive, and aesthetic surgeons in Dr. Sardjito hospital have frequently done wall suction VAC in various wounds, with successful results following the VAC treatment [18] , [19] . In contrast, as outpatient therapy, we changed the honey wound dressing every two days because of the absence of a portable suction VAC in our hospital.…”

Section: Discussionmentioning

confidence: 99%

The use of Indonesian randu honey for chronic wounds in a patient with uncontrolled type 2 diabetes mellitus: A case report

Wahdini

Seswandhana

Vityadewi

et al. 2022

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

The use of Indonesian randu honey for chronic wounds in a patient with uncontrolled type 2 diabetes mellitus: A case report

Wahdini

Seswandhana

Vityadewi

et al. 2022

International Journal of Surgery Case Reports

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“…Resistance to conventional antibiotics, especially in ESKAPE pathogens, has become a global health problem associated with high morbidity and mortality ( 1 , 2 ). The acronym ESKAPE refers to a group of life-threatening nosocomial pathogens, including Enterococcus faecium (E. faecium), Staphylococcus aureus (S. aureus), Klebsiella pneumonia (K. pneumonia), Acinetobacter baumannii (A. baumannii), Pseudomonas aeruginosa (P. aeruginosa), and Enterobacter spp.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity and Toxicity of Zinc Oxide Nanoparticles Combined with Supernatants of Lactobacillus spp. Against ESKAPE Bacteria: A Novel Mixture

Soleymanzadeh,

Hosseini Doust,

Majidpour

et al. 2023

Iran J Pharm Res

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Background: The emergence of multidrug resistance among nosocomial pathogens has prompted researchers to look for new antibacterial sources. Metal nanoparticles and probiotic products have attracted the attention of researchers. However, combination therapy is an attractive alternative in this field. Objectives: This study evaluated the antibacterial activity and toxicity of Zinc Oxide nanoparticles (ZnO-NPs) combined with Cell-free Supernatant (CFS) of Lactobacillus plantarum (L. plantarum) and Lactobacillus acidophilus (L. acidophilus) alone and in a novel mixture. Methods: Antibacterial effects and cytotoxic properties of ZnO-NPs, CFS of L. plantarum (SLP), and CFS of L. acidophilus (SLA) were determined alone and in a mixture against ESKAPE strains. In addition, the viability percentage of the cells was evaluated after exposure to these agents. Results: Antibacterial mixtures (ZnO-NPs with SLP or ZnO-NPs with SLA) demonstrated synergistic and additive effects against Pseudomonas aeruginosa (FIC≤0.75), Acinetobacter baumannii (FIC = 1), and Escherichia coli (FIC≤0.75). The viability percentage of the cells after 24 h of exposure to a mixture of ZnO-NPs and SLA (about 50%) was more than when the cells were exposed to ZnO-NPs alone (about 30%) at the same concentration. Conclusions: A mixture of ZnO-NPs and CFS of probiotics can be an alternative to antibiotics, with more effectiveness and fewer side effects.

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“…Burn injuries are a major global health problem and a significant cause of mortality and morbidity worldwide (1,2). Burn treatment imposes great costs on patients, families, and the healthcare system.…”

Section: Introductionmentioning

confidence: 99%

“…L. plantarum 299v secretes antibacterial substances such as lactic acid, benzoic acid, hydrogen peroxide, bacteriocins, and short-chain fatty acids (SCFAs) (2,21). L. plantarum lowers the intestinal pH and creates an unfavorable environment for the growth of pathogens (1,2). BFS of probiotics contains antibacterial agents that regulate the population composition of normal flora and thus reduce the incidence of bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

Topical Treatment of Second-Degree Burn Wounds with Lactobacillus plantarum Supernatant: Phase I Trial

et al. 2022

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Scan to discover onlineBackground & Objective: A burn wound is sterile immediately after injury, but opportunistic bacteria colonize the wound within 48 to 72 hours after the burn, causing delayed or failed burn wound healing. In addition, the presence of multidrug-resistant (MDR) pathogens doubles the treatment problems. Lactobacillus plantarum (L. plantarum) is a well-known antibacterial and healing agent that could be used topically to treat burn wounds. Case Series Presentation:This clinical trial study (Case Series) was performed on 20 patients with deep second-degree burns. Patients had bilateral wounds; the wound on one side of the body was considered as control (treated with silver sulfadiazine) and the other side of the body as treatment (treated with bacteria-free supernatants (BFS) of L. plantarum). The wounds were evaluated by microbial assessments and assessments related to healing. Pseudomonas aeruginosa, Klebsiella pneumonia, and Staphylococcus aureus were isolated from 4 (22.2%), 0%, and 2 (11.1%) of wounds treated with L. plantarum on the fifth day of the treatment, respectively. Furthermore, 12 (66.7%) of wounds treated with L. plantarum were free from bacteria. The need for skin grafting was the same in both treatment and control groups, but graft rejection in the group treated with L. plantarum was (0%) (P=0.02). Conclusion:Regarding eliminating or reducing infection and wound healing, bacteria-free supernatants of L. plantarum can be considered a possible topical treatment option in the case of second-degree burn wounds.

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A case series of negative pressure wound therapy as a promising treatment in patients with burn injury

Cited by 7 publications

References 14 publications

The use of Indonesian randu honey for chronic wounds in a patient with uncontrolled type 2 diabetes mellitus: A case report

The use of Indonesian randu honey for chronic wounds in a patient with uncontrolled type 2 diabetes mellitus: A case report

Antibacterial Activity and Toxicity of Zinc Oxide Nanoparticles Combined with Supernatants of Lactobacillus spp. Against ESKAPE Bacteria: A Novel Mixture

Topical Treatment of Second-Degree Burn Wounds with Lactobacillus plantarum Supernatant: Phase I Trial

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