A case series of mucormycosis and aspergillus coinfection in post-covid-19 patient with uncontrolled diabetic

Abstract

Mucormycosis is an angioinvasive infection caused by fungi Mucorales which mainly occurs in immunocompromised patients. Aspergillosis is also an opportunistic fungal infection caused by Aspergillus species. Coinfection with mucormycosis and aspergillosis is very rare and very few cases were published in the literature till now. There is an increase in the incidence of mucormycosis infection in post-COVID-19 patients. Here, we are going to report a case series of three cases of combined infection of mucormycosis with Aspergillus. All three patients were treated with extensive surgical debridement and intravenous liposomal amphotericin B. Even after aggressive treatment, the mortality rate is high in these types of patients.

Development of a monoclonal antibody and a lateral-flow device for the rapid detection of a Mucorales-specific biomarker

“…Importantly, mAb TG11 does not cross-react with other fungal pathogens which have been encountered in mixed infections with Mucorales spp., including Aspergillus spp. (Arndt et al, 2009;Bergantim et al, 2013;Henn et al, 2014;Obradovic-Tomasev et al, 2014;Pandey et al, 2019;Anita et al, 2021; Bellanger Benhadid-Brahmi et al, 2022;Johnson et al, 2021;Moorthy et al, 2021;Paul et al (2022); Ramıŕez-Hinojosa et al, 2021;Singh et al, 2021;Zayet et al, 2021;Rahna et al, 2022;Suresh et al, 2022;Tabarsi et al, 2022;Teng et al, 2022;Zhan et al, 2022;Murray et al, 2023;Sardeshmukh et al, 2023), Fusarium spp. (De Almeida Junior et al, 2015;Marino et al, 2023), Candida albicans (Obradovic-Tomasev et al, 2014;Pandey et al, 2019;Jawanda et al, 2022), Cryptococcus neoformans (Henn et al, 2014;Gupta et al, 2023), Lomentospora prolificans (Erami et al, 2023), and Scedosporium apiospermum (Shand et al, 2004;Marques et al, 2011;Song et al, 2022;Kanaujia et al, 2023).…”

Coinfection by Aspergillus and Mucoraceae Species in Two Cases of Acute Rhinosinusitis as a Complication of COVID-19

“…The patients were treated with surgical debridement combined with intravenous liposomal amphotericin B, and two cases received step-down therapy with posaconazole. One of the cases was a 52-year-old female with a history of diabetes mellitus [ 20 ]. In another report, a 55-year-old diabetic male patient was hospitalized with a three-day history of dyspnea, fever, and generalized malaise.…”